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Träfflista för sökning "WFRF:(Mallinson T) "

Sökning: WFRF:(Mallinson T)

  • Resultat 1-5 av 5
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1.
  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
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2.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
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3.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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4.
  • Grenier-Pleau, I., et al. (författare)
  • Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
  • 2020
  • Ingår i: Aging Cell. - : Wiley. - 1474-9718 .- 1474-9726. ; 19:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Hematopoietic stem cells (HSCs) maintain balanced blood cell production in a process called hematopoiesis. As humans age, their HSCs acquire mutations that allow some HSCs to disproportionately contribute to normal blood production. This process, known as age-related clonal hematopoiesis, predisposes certain individuals to cancer, cardiovascular and pulmonary pathologies. There is a growing body of evidence suggesting that factors outside cells, such as extracellular vesicles (EVs), contribute to the disruption of stem cell homeostasis during aging. We have characterized blood EVs from humans and determined that they are remarkably consistent with respect to size, concentration, and total protein content, across healthy subjects aged 20-85 years. When analyzing EV protein composition from mass spectroscopy data, our machine-learning-based algorithms are able to distinguish EV proteins based on age and suggest that different cell types dominantly produce EVs released into the blood, which change over time. Importantly, our data show blood EVs from middle and older age groups (>40 years) significantly stimulate HSCs in contrast to untreated and EVs sourced from young subjects. Our study establishes for the first time that although EV particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during aging and potentially influences HSC regulation.
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5.
  • Mallinson, T, et al. (författare)
  • Metaphor and meaning in a clinical interview
  • 1996
  • Ingår i: The American journal of occupational therapy : official publication of the American Occupational Therapy Association. - : AOTA Press. - 0272-9490. ; 50:5, s. 338-346
  • Tidskriftsartikel (refereegranskat)abstract
    • This study examined the narrative features of 20 life histories gathered from psychiatric patients with the Occupational Performance History Interview. The aim was to identify how narrative features were present in the patient interview responses and to illustrate how such narrative features can be located. We found that the patients organized their interview responses with deep metaphors that served to “emplot, ” or give meaning to, the life story. This article illustrates how patients used the deep metaphors to both circumscribe and frame possible solutions to the problems in their lives. Deep metaphors are consistent, recurring images of a life story that give coherence to, and aid in, the interpretation of the events of that life. Moreover, we explored how metaphors can be located in patient life histories and their implications for occupational therapy.
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  • Resultat 1-5 av 5

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