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1.	Jakobsson, J., et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Journal article (peer-reviewed)
2.	Ammirati, E, et al. (author) Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6- interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction 2012 In: Circulation research. - 1524-4571. ; 111:10, s. 1336-U242 Journal article (peer-reviewed)
3.	Kepp, O, et al. (author) Consensus guidelines for the detection of immunogenic cell death 2014 In: Oncoimmunology. - : Informa UK Limited. - 2162-4011 .- 2162-402X. ; 3:9, s. e955691- Research review (peer-reviewed)
4.	Lyons, PA, et al. (author) Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 5120- Journal article (peer-reviewed)abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.

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Type of publication: journal article (3); research review (1)

Type of content: peer-reviewed (4)

Author/Editor: Liu, X (1); Chen, L (1); Alonso, A. (1); Chen, S. (1); Chen, X. (1); Chen, Y. (1); show more...; Donadelli, M. (1); Gabrielli, A. (1); Gupta, S. (1); Hu, D. (1); Jiang, Y. (1); Jin, S. (1); Kim, H. (1); Kono, T. (1); Li, B. (1); Li, S. (1); Li, Y. (1); Liu, Y. (1); Meyer, C. (1); Mohapatra, S. (1); Nakamura, K. (1); Nilsson, P. (1); Shimizu, S. (1); Takahashi, Y. (1); Wang, C. (1); Wang, F. (1); Wang, H. (1); Wang, J. (1); Wang, K. (1); Wu, M. (1); Xu, L. (1); Yamamoto, A. (1); Yan, Z. (1); Yang, H. (1); Yang, Y. (1); Yu, J. (1); Zhang, H. (1); Zhang, L. (1); Zhang, X. (1); Zhang, Z. (1); Zhou, B. (1); Zhu, H. (1); Liu, J. (1); Zhao, Y. (1); Lange, C. (1); Li, X. (1); Zhao, L. (1); Liu, C. (1); Liu, H. (1); Saito, T (1); show less...

University: Karolinska Institutet (4); Lund University (2); Umeå University (1); Uppsala University (1); Stockholm University (1); Linköping University (1); show more...; Swedish University of Agricultural Sciences (1); show less...

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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