| 1. |
- Day, Louise T., et al.
(författare)
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"Every Newborn-BIRTH" protocol : observational study validating indicators for coverage and quality of maternal and newborn health care in Bangladesh, Nepal and Tanzania
- 2019
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Ingår i: Journal of Global Health. - : International Global Health Society. - 2047-2978 .- 2047-2986. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: To achieve Sustainable Development Goals and Universal Health Coverage, programmatic data are essential. The Every Newborn Action Plan, agreed by all United Nations member states and >80 development partners, includes an ambitious Measurement Improvement Roadmap. Quality of care at birth is prioritised by both Every Newborn and Ending Preventable Maternal Mortality strategies, hence metrics need to advance from health service contact alone, to content of care. As facility births increase, monitoring using routine facility data in DHIS2 has potential, yet validation research has mainly focussed on maternal recall surveys. The Every Newborn - Birth Indicators Research Tracking in Hospitals (EN-BIRTH) study aims to validate selected newborn and maternal indicators for routine tracking of coverage and quality of facility-based care for use at district, national and global levels.Methods: EN-BIRTH is an observational study including >20000 facility births in three countries (Tanzania, Bangladesh and Nepal) to validate selected indicators. Direct clinical observation will be compared with facility register data and a pre-discharge maternal recall survey for indicators including: uterotonic administration, immediate newborn care, neonatal resuscitation and Kangaroo mother care. Indicators including neonatal infection management and antenatal corticosteroid administration, which cannot be easily observed, will be validated using inpatient records. Trained clinical observers in Labour/Delivery ward, Operation theatre, and Kangaroo mother care ward/areas will collect data using a tablet-based customised data capturing application. Sensitivity will be calculated for numerators of all indicators and specificity for those numerators with adequate information. Other objectives include comparison of denominator options (ie, true target population or surrogates) and quality of care analyses, especially regarding intervention timing. Barriers and enablers to routine recording and data usage will be assessed by data flow assessments, quantitative and qualitative analyses.Conclusions: To our knowledge, this is the first large, multi-country study validating facility-based routine data compared to direct observation for maternal and newborn care, designed to provide evidence to inform selection of a core list of indicators recommended for inclusion in national DHIS2. Availability and use of such data are fundamental to drive progress towards ending the annual 5.5 million preventable stillbirths, maternal and newborn deaths.
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| 2. |
- Gateva, Vesela, et al.
(författare)
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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:11, s. 1228-1233
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P< or = 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.
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| 3. |
- Manzi, Musa S. D., et al.
(författare)
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Improved structural interpretation of legacy 3D seismic data from Karee platinum mine (South Africa) through the application of novel seismic attributes
- 2020
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Ingår i: Geophysical Prospecting. - : WILEY. - 0016-8025 .- 1365-2478. ; 68:1, s. 145-163
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Tidskriftsartikel (refereegranskat)abstract
- Seismic detection of faults, dykes, potholes and iron-rich ultramafic pegmatitic bodies is of great importance to the platinum mining industry, as these structures affect safety and efficiency. The application of conventional seismic attributes (such as instantaneous amplitude, phase and frequency) in the hard-rock environment is more challenging than in soft-rock settings because the geology is often complex, reflections disrupted and the seismic energy strongly scattered. We have developed new seismic attributes that sharpen seismic reflections, enabling additional structural information to be extracted from hard-rock seismic data. The symmetry attribute is based on the invariance of an object with respect to transformations such as rotation and reflection; it is independent of the trace reflection amplitude, and hence a better indicator of the lateral continuity of thin and weak reflections. The reflection-continuity detector attribute is based on the Hilbert transform; it enhances the visibility of the peaks and troughs of the seismic traces, and hence the continuity of weak reflections. We demonstrate the effectiveness of these new seismic attributes by applying them to a legacy 3D seismic data set from the Bushveld Complex in South Africa. These seismic attributes show good detection of deep-seated thin (similar to 1.5 m thick) platinum ore bodies and their associated complex geological structures (faults, dykes, potholes and iron-rich ultramafic pegmatites). They provide a fast, cost-effective and efficient interpretation tool that, when coupled with horizon-based seismic attributes, can reveal structures not seen in conventional interpretations.
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| 4. |
- Manzi, Maria Virginia, et al.
(författare)
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Sex-Related Differences in Thrombus Burden in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
- 2022
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Ingår i: JACC. - : Elsevier. - 1936-8798 .- 1876-7605. ; 15:20, s. 2066-2076
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Women have a worse prognosis after ST-segment elevation myocardial infarction (STEMI) than men. The prognostic role of thrombus burden (TB) in influencing the sex-related differences in clinical outcomes after STEMI has not been clearly investigated.OBJECTIVES: The aim of this study was to assess the sex-related differences in TB and its clinical implications in patients with STEMI.METHODS: Individual patient data from the 3 major randomized clinical trials of manual thrombus aspiration were analyzed, encompassing a total of 19,047 patients with STEMI, of whom 13,885 (76.1%) were men and 4,371 (23.9%) were women. The primary outcome of interest was 1-year cardiovascular (CV) death. The secondary outcomes of interest were recurrent myocardial infarction, heart failure, all-cause mortality, stroke, stent thrombosis (ST), and target vessel revascularization at 1 year.RESULTS: Patients with high TB (HTB) had worse 1-year outcomes compared with those presenting with low TB (adjusted HR for CV death: 1.52; 95% CI: 1.10-2.12; P = 0.01). In unadjusted analyses, female sex was associated with an increased risk for 1-year CV death regardless of TB. After adjustment, the risk for 1-year CV death was higher only in women with HTB (HR: 1.23; 95% CI: 1.18-1.28; P < 0.001), who also had an increased risk for all-cause death and ST than men.CONCLUSIONS: In patients with STEMI, angiographic evidence of HTB negatively affected prognosis. Among patients with HTB, women had an excess risk for ST, CV, and all-cause mortality than men. Further investigations are warranted to better understand the pathophysiological mechanisms leading to excess mortality in women with STEMI and HTB.
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| 6. |
- Tschiderer, Lena, et al.
(författare)
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Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies
- 2023
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Ingår i: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development.Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques).Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
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| 7. |
- Westgate, Michael, et al.
(författare)
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A reappraisal of legacy reflection seismic data from the western margin of the Kaapvaal craton, South Africa, with implications for Mesozoic-Cenozoic regional tectonics
- 2021
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Ingår i: Tectonophysics. - : Elsevier. - 0040-1951 .- 1879-3266. ; 813
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Tidskriftsartikel (refereegranskat)abstract
- The 150 km long, 6 s TWT, 2D seismic profile KBF03A, which was acquired in 1994 and lies near the western edge of the Kaapvaal craton in South Africa, has been reprocessed using standard reflection seismic processing methods. The results exhibit a significant improvement in the imaging quality of the subsurface features and an evident boost in the signal-to-noise ratio. The improved seismic data, combined with application of seismic attributes, integration with surficial geological and geophysical maps, and computation of velocity tomograms, has revealed previously undetected structural features within the supracrustal sequences underlying the profile. In particular, the Phanerozoic sediments found along the profile, comprising exclusively Kalahari Group and Dwyka Group deposits, are disrupted by multiple folds of varying wavelengths (similar to 1 similar to 10 km) and variably oriented normal and thrust faults. Additionally, the effect of the Moshaweng fault, previously characterised as a listric fault extending to depths of >10 km, on the Phanerozoic sediments has been further constrained to suggest repeated extensional reactivations and a more recent (<1 Ma) inversion. Considerations of the eastern end of the profile have suggested links between some of the observed structural features and the nearby similar to 146 Ma Morokweng impact structure, the lateral expanse of which is poorly constrained in the literature. The collection of these newly imaged features is interpreted as evidence for multiple Late Mesozoic to Cenozoic tectonic events, including polyphasic reactivation of basement structures, under both extensional and compressional stress regimes. By analysing these newly detected features, our study not only provides new insight into the neotectonic evolution of the Phanerozoic sediments along the western margin of the Kaapvaal craton, but also demonstrates the utility in reprocessing legacy data and reveals its untapped potential.
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