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Sökning: WFRF:(Marcusson Jan) > Blennow K

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1.
  • Nägga, Katarina, et al. (författare)
  • Cerebrospinal fluid phospho-tau, total tau and β-amyloid1-42 in the differentiation between Alzheimer's disease and vascular dementia
  • 2002
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 14:3-4, s. 183-190
  • Tidskriftsartikel (refereegranskat)abstract
    • The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and β-amyloid1-42 (Aβ1-42). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; n = 23), probable AD (n = 50), AD with relevant cerebrovascular disease (AD with CVD; n = 14), possible vascular dementia (VaD; n = 39), probable VaD (n = 36), cognitively impaired (n = 13) and 27 neurologically healthy controls. Compared with the controls, tau levels were significantly increased in possible AD, probable AD, AD with CVD and probable VaD. Aβ1-42 was decreased in all dementia groups compared with the controls. In contrast, phospho-tau levels were increased only in probable AD compared with the controls. From the results of the present study, it is concluded that neither measurement of phospho-tau, tau nor Aβ1-42 in CSF can discriminate entirely between dementia and cognitively non-disturbed controls or between dementia of different aetiologies in the clinical diagnostic procedure.
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  • Sundman, I, et al. (författare)
  • Increased [3H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia
  • 2002
  • Ingår i: Neuropsychobiology. - : S. Karger AG. - 0302-282X .- 1423-0224. ; 45:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Postmortem samples from individuals with schizophrenia (n = 13) and control subjects (n = 10) were investigated for binding of [3H]tiagabine to GABA transporter-1 GAT-1. The binding was analyzed in the cingulate cortex and the caudate nucleus. There were no differences in binding affinity between the groups in any of the investigated areas. The maximum number of binding sites (Bmax) was elevated in the schizophrenic cingulate cortex compared to controls (1,264 ▒ 96 vs. 860 ▒ 123 fmol/mg of protein). The Bmax in the caudate nucleus for schizophrenics (426 ▒ 40 fmol/mg of protein) was the same as for controls (495 ▒ 69 fmol/mg of protein). The increase in GAT-1 in schizophrenia could be explained by a modulatory upregulation in the cingulate cortex. Copyright ⌐ 2002 S. Karger AG, Basel.
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