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Träfflista för sökning "WFRF:(Marklund Stefan L.) ;pers:(Jansson Jan Håkan)"

Sökning: WFRF:(Marklund Stefan L.) > Jansson Jan Håkan

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1.
  • Ekblom, Kim, 1970-, et al. (författare)
  • Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction : a prospective nested case-referent study
  • 2011
  • Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 150:2, s. 169-172
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction. Methods: First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined. Results: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction. Conclusions: No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
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2.
  • Ekblom, Kim, 1970-, et al. (författare)
  • Plasma Bilirubin and UGT1A1*28 Are Not Protective Factors Against First-Time Myocardial Infarction in a Prospective, Nested Case–Referent Setting
  • 2010
  • Ingår i: Circulation. - Philadelphia, PA : Lippincott Williams & Wilkins. - 1942-325X .- 1942-3268. ; :3, s. 340-347
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Bilirubin, an effective antioxidant, shows a large variation in levels between individuals and has been positively associated with reduced cardiovascular disease risk. A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1. The aim of the study was to evaluate a possible protective effect of plasma bilirubin and the UGT1A1*28 polymorphism against myocardial infarction in a prospective case-referent setting.Methods and Results: 618 subjects with a first-ever myocardial infarction (median event age 60.5 years, median lag time 3.5 years) and 1184 matched referents were studied. Plasma bilirubin was lower in cases vs. referents. Despite a strong gene-dosage effect on bilirubin levels in both cases and referents, the UGT1A1*28 polymorphism did not influence the risk of myocardial infarction. Among multiple other variables, serum iron showed one of the strongest associations with bilirubin levels.Conclusion: We found no evidence for a protective effect of the UGT1A1*28 polymorphism against myocardial infarction and consequently neither for bilirubin. The lower bilirubin levels in cases might be caused by decreased production, increased degradation or increased elimination.
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  • Resultat 1-3 av 3
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tidskriftsartikel (3)
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refereegranskat (3)
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Hallmans, Göran (3)
Marklund, Stefan L. (3)
Hultdin, Johan (3)
Weinehall, Lars (3)
Osterman, Pia (2)
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Ekblom, Kim, 1970- (2)
Ekblom, Kim (1)
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Umeå universitet (3)
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Medicin och hälsovetenskap (3)

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