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- de Rojas, I., et al.
(författare)
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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| 2. |
- Lopes-Martínez, I., et al.
(författare)
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Problemas de codificación de productos que afectan la gestión deinventarios: Caso de estudio en empresas cubanas [Problems of code of products that affect the inventory management: Cuban companies case study]
- 2014
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Ingår i: Dyna. - : Universidad Nacional de Colombia. - 0012-7353 .- 2346-2183. ; 81:187, s. 64-72
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Tidskriftsartikel (refereegranskat)abstract
- Numerous code systems and classification of products and services exist globally, being tendency the standardization of them in the supply chains to achieve higher integration. The correct use of these systems is considered essential in the effectiveness in the inventory management, given its direct relationship with the registration of the primary information and tracing of the products. However, the scientific literature and the academic programs concentrate mostly on the Auto-ID technologies more than in the code structure and the consequences of an incorrect use of the code. The present article reflects the main deficiencies possible to detect in the systems of code of products, using a sample of companies in Cuba. The consequences of these deficiencies are discussed and it is also included a proposal of organization of the code for the Cuban companies. © The author; licensee Universidad Nacional de Colombia.
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| 3. |
- Martínez-Alonso, R., et al.
(författare)
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Process innovation in family firms : Family involvement in management, R&D collaboration with suppliers, and technology protection
- 2023
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Ingår i: Journal of Business Research. - : Elsevier. - 0148-2963 .- 1873-7978. ; 157
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on insights from the upper echelon theory, this article aims to examine the impact of family involvement in management on process innovation within family firms, considering the mediating role of R&D collaboration with suppliers and the moderating role of technology protection. Conducting a panel data analysis on 5,332 firm-year observations of Spanish manufacturing family firms for the period 2007–2016, we find that the negative relationship between family involvement in management and process innovation is mediated by R&D collaboration with suppliers. Furthermore, we find that the negative effect of family involvement in management on R&D collaboration with suppliers and ultimately on process innovation is mitigated by technology protection and even becomes positive for high levels of technology protection.
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