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> Huikuri H >
ECG markers associa...
ECG markers associated with ischemic stroke at young age - a case-control study
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Pirinen, J. (author)
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Eranti, A. (author)
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Knekt, P. (author)
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Lehto, M. (author)
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Martinez-Majander, N. (author)
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Aro, A. L. (author)
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Rissanen, H. (author)
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Heliovaara, M. (author)
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Kaste, M. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Huikuri, H. (author)
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Putaala, J. (author)
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(creator_code:org_t)
- 2017-07-14
- 2017
- English.
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In: Annals of Medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 49:7, s. 562-568
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Introduction: Certain electrocardiographic (ECG) abnormalities are associated with ischemic stroke (IS), especially cardioembolic subtype. Besides atrial fibrillation, markers of left ventricular hypertrophy (LVH) or atrial pathology also reflect elevated risk. We studied the association of ECG markers with IS in young adults. Methods: We performed a case-control study including 567 consecutive IS patients aged 15-49 years (inclusion period: 1994-2007) and one or two age-and sex-matched control subjects enrolled during 1978-1980 (n = 1033), and investigated also the stroke aetiologic subgroups. We studied ECGs of all participants for markers of atrial abnormality, i.e. P-terminal force (PTF) on lead V1, interatrial blocks (IAB; P-wave duration >= 110ms), and LVH. Conditional logistic regression analyses were used. Results: IAB (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.16-2.13) and PTF combined with LVH (HR: 6.83, 95% CI: 1.65-28.31), were independently associated with IS. LVH, abnormal P-wave (HR: 6.87, 95% CI: 1.97-135.29), PTF, IAB, and combinations of these P-wave abnormalities with LVH - were associated with cardioembolic subtype. Abnormal P-wave and IAB were associated with cryptogenic stroke subtype. In unadjusted analysis, LVH was associated with small-vessel disease subtype. Conclusion: P-wave abnormalities on ECG were associated with cardioembolic but also with a cryptogenic subtype of IS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cardioembolism
- case-control study
- cryptogenic stroke
- electrocardiographic
- embolic strokes of
- left-ventricular hypertrophy
- left atrial abnormalities
- p-wave
- morphology
- interatrial block
- terminal force
- hypertensive patients
- atherosclerosis risk
- general-population
- predicting stroke
- embolic
- stroke
- General & Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pirinen, J.
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Eranti, A.
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Knekt, P.
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Lehto, M.
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Martinez-Majande ...
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Aro, A. L.
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show more...
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Rissanen, H.
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Heliovaara, M.
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Kaste, M.
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Tatlisumak, Turg ...
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Huikuri, H.
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Putaala, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Annals of Medici ...
- By the university
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University of Gothenburg