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Reduced intensity c...
Reduced intensity conditioning increases risk of severe cGVHD : identification of risk factors for cGVHD in a multicenter setting
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- Afram, Gabriel (author)
- Karolinska Institutet
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- Perez Simon, Jose Antonio (author)
- Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Hematol,Inst Biomed Sevilla IBIS, Seville, Spain
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- Remberger, Mats (author)
- Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat, Stockholm, Sweden
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- Caballero-Velazquez, Teresa (author)
- Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Hematol,Inst Biomed Sevilla IBIS, Seville, Spain
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- Martino, Rodrigo (author)
- Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
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- Luis Pinana, Jose (author)
- Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain;Hosp Clin Univ, Dept Hematol, Valencia, Spain
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- Ringden, Olle (author)
- Karolinska Institutet
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- Esquirol, Albert (author)
- Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
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- Lopez-Corral, Lucia (author)
- Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain
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- Garcia, Irene (author)
- Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
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- Lopez-Godino, Oriana (author)
- Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain
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- Sierra, Jordi (author)
- Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
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- Caballero, Dolores (author)
- Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain
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- Ljungman, Per (author)
- Karolinska Institutet
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- Vazquez, Lourdes (author)
- Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain
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- Hägglund, Hans (author)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- 2018-04-25
- 2018
- English.
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In: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 35:6
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p < 0.001], prior acute GVHD [1.30, p = 0.024], and RIC [1.36, p = 0.028] increased overall cGVHD. In addition, RIC [4.85, p < 0.001], prior aGVHD [2.14, p = 0.001] and female donor to male recipient [1.80, p = 0.008] increased the risk of severe cGVHD. ATG had a protective effect for both overall [0.41, p < 0.001] and severe cGVHD [0.20, p < 0.001]. Relapse-free survival (RFS) was impaired in patients with severe cGVHD. RIC, prior aGVHD, and female-to-male donation increase the risk of severe cGVHD. ATG reduces the risk of all grades of cGVHD without hampering RFS. GVHD prophylaxis may be tailored according to the risk profile of patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- ATG
- Graft-versus-host disease (GVHD)
- Risk factor
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Afram, Gabriel
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Perez Simon, Jos ...
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Remberger, Mats
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Caballero-Velazq ...
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Martino, Rodrigo
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Luis Pinana, Jos ...
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Ringden, Olle
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Esquirol, Albert
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Lopez-Corral, Lu ...
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Garcia, Irene
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Lopez-Godino, Or ...
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Sierra, Jordi
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Caballero, Dolor ...
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Ljungman, Per
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Vazquez, Lourdes
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Hägglund, Hans
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Medical Oncology
- By the university
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Uppsala University
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Karolinska Institutet