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Träfflista för sökning "WFRF:(Mellström Dan 1945) ;conttype:(scientificother)"

Sökning: WFRF:(Mellström Dan 1945) > Övrigt vetenskapligt/konstnärligt

  • Resultat 1-8 av 8
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1.
  • Bokrantz, Tove, et al. (författare)
  • Reply.
  • 2017
  • Ingår i: Journal of hypertension. - 1473-5598. ; 35:3, s. 646-647
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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2.
  • Eriksson, Bo G., 1944, et al. (författare)
  • Socio-Economic indicators of health among the elderly in Sweden
  • 1985
  • Ingår i: Sjunde nordiska kongressen i gerontologi, Malmö 10-12 september 1984, Redaktörer Ove Dehlin och Bertil Steen. - 9197066427 ; , s. 373-375
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Hammarsten, J, et al. (författare)
  • HYPOADIPONECTINEMI – A RISK FACTOR FOR BENIGN PROSTATIC HYPERPLASIA
  • 2009
  • Ingår i: International Congress on Prediabetes and the Metabolic Syndrome.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • HYPOADIPONECTINEMI – A RISK FACTOR FOR BENIGN PROSTATIC HYPERPLASIA Authors: J Hammarsten1, C J Behre2, J-E Damber3, T Knutson3, R Peeker3, D Mellström 4 (1)Skaraborg Hospital, Department of Urology, Skövde, Sweden, (2) Sahlgrenska University Hospital, Institute of Internal Medicine, Göteborg, Sweden, (3) Sahlgrenska University Hospital, Department of Urology, Göteborg, Sweden, (3) Sahlgrenska University Hospital, Center for bone research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg, Sweden Hypoadiponectinemi has recently been shown to be related to the metabolic syndrome. Our group has over the last 15 years suggested that benign prostatic hyperplasia (BPH) is a component of the metabolic syndrome. In our reports we have found that 19 out of 21 conditions that are associated to the metabolic syndrome also were risk factors for BPH. The aim of the present study was to investigate the correlation between serum adiponectin levels and BPH. Given the strong correlation between BPH and the metabolic syndrome, it could be hypothesized that there is a statistical significant inverse correlation between the prostate gland volume and the circulating adiponectin levels. Material and methods: One thousand representative men, aged 72 – 76 years, living in Göteborg, Sweden involved in the Mr Os study were recruited. The Mr Os study is an international study of male osteoporosis. In 184 men, a subgroup of the total population, the prostate gland volume was determined. Serum adiponectin was determined using human adiponectin ELISA kit. Results: Men, previously diagnosed with prostate cancer or having had a prostate operation, were excluded after which 157 men remained. The mean prostate gland volume was 46 ml (13 – 139 ml). The mean adiponectin level was 11.2+5.7µg/mL(SD). Using univariate analysis, adiponectin correlated inversely with the prostate gland volume (R=-158, P=0.0481). Using multivariate analysis, adjusting for insulin, glucose and trunk fat mass, adiponectin did not come out statistically significantly. In the total material, adiponectin correlated inversely with insulin (R=-0.340, P<0.0001), glucose (R=-0.186, P<0.0001), BMI (R=-0.271, P<0.0001, trunk fat mass (R=-0.315, P<0.0001) and lean body mass (R=-0.185, P<0.0001). Conclusion: Our data show for the first time that hypoadiponectinemi is a risk factor for BPH. This is in conjunction with our suggestion that BPH is a component of the metabolic syndrome. Our data also confirm that hypoadiponectinemi is related to the metabolic syndrome.
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5.
  • Löfman, Owe, 1945- (författare)
  • Osteoporosis in women : Epidemiological and diagnostic perspectives
  • 2002
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • An epidemiological study of 15.462 hip fractures in Östergötland 1940-86 showed a large incidence increase mainly due to an increase in age-specific incidence of trochanteric fractures. A trendforecast assuming the same increase in incidence as over the study period and a population forecast according to the official prognosis, predicted 70% more hip fractures in the year 2000 compared to 1985. The different forecasts models were validated for the year 1995 and showed a good correlation between estimated and observed number of fractures, but varied dependent on which fracture and prognosis model that were evaluated.A follow-up investigation of 11.517 hip fractures 1982-96 showed a downturn in incidence of female fractures and a continous increase for males, particularly of trochanteric fractures. A trend brake was thus seen and this continues up to 2010 according to our trendforecasts but may be counteracted by the increasing number of elderly after 2020. Gender ratio changed over time with increasing number of male fractures, more trochanteric fractures relative to cervical (c/t-ratio) and an increasing mean age of the fracture patient.Age specific reference values were established for bone mineral density (BMD) in forearm, lumbar spine and hip after investigation of 429 women 20-80 years, randomly sampled from the general population. Bone density was assessed from cross-sectional data for the various skeletal sites over an almost complete adult life period and these were then compared to values obtained from other studies, densitometry technologies and reference materials. Large discordances were found between the different technologies and reference materials.The outcome of using the T-score proposed by a WHO study group 1994 as a diagnostic cutoff principle for the diagnosis of osteoporosis (T<-2.5) and osteopenia (T<-1 - -2.5) was evaluated by calculating the resulting prevalence in a cohort of 210 women, 70 years of age. The use of different approaches in calculation of T -score and different reference samples, yielded unacceptable disparities in disease prevalence of between 9 and 72%. The differences were also heavely dependent of which and how many sites that were included in the diagnostic decision.We studied biochemical markers of bone turnover (alkaline phosphatase, osteocalcin, hydroxyproline and calcium excretion in the urine) in relation to age, menopause and BMD, and their ability to predict bone loss in a 5-year follow-up perspective. Markers varied inversely to BMD, increased markedly at menopause and predicted bone loss over the next 5 years up to 75% at individual level, (AUC of an ROC analysis).A case. finding strategy using low-energy index fractures in forearm, spine, hip or humerus was performed to detect subjects with osteoporosis. 303 consecutive women 55-75 years with a recent fracture were examined with densitometry and a risk profile questionnaire. The lowest BMD was found in spine and hip fracture patients. Odds ratio for osteoporosis was at least 8 for a patient with a prior hip fracture. The number of previous fractures correlated inversely with bone density (Z-score). Despite 92% of the fracture patients (many with a multiple fracture history) had a low bone mass (t-score<1), only 15% had been treated for osteoporosis before the index fracture.
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  • Wallin, Maria, et al. (författare)
  • Response to "Low-Level Cadmium Exposure and Bone Health".
  • 2017
  • Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - : Wiley. - 1523-4681. ; 32:2, s. 420-421
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-8 av 8

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