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Sökning: WFRF:(Mielke Matthew)

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1.
  • Stamatakis, Emmanuel, et al. (författare)
  • A Physical Behaviour Partnership From Heaven : The Prospective Physical Activity, Sitting, and Sleep Consortium and the International Society for the Measurement of Physical Behaviour
  • 2022
  • Ingår i: Journal for the Measurement of Physical Behaviour. - : Human Kinetics. - 2575-6605 .- 2575-6613. ; , s. 1-3
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The advancement of science demands people and organizations work together toward worthy goals, a need that is especially pronounced in nascent fields like physical behavior. Partnerships offer an ideal vehicle for long-term collaboration to build research capacity, develop new scientific endeavors, and nurture talent. In this commentary, we discuss the newly formed partnership between two key players of the field of physical behavior, the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS) and the International Society for the Measurement of Physical Behaviour (ISMPB).
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2.
  • Blom, Elin S, et al. (författare)
  • Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
  • 2010
  • Ingår i: International journal of Alzheimer's disease. - : Hindawi Limited. - 2090-0252 .- 2090-8024. ; 2011, s. 936580-
  • Tidskriftsartikel (refereegranskat)abstract
    • Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P < .05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.
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