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Träfflista för sökning "WFRF:(Mills Stuart J.) "

Sökning: WFRF:(Mills Stuart J.)

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1.
  • Weinstein, J. N., et al. (författare)
  • The cancer genome atlas pan-cancer analysis project
  • 2013
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
  • Tidskriftsartikel (refereegranskat)abstract
    • The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.
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2.
  • Grew, Edward S., et al. (författare)
  • Nomenclature of the garnet supergroup
  • 2013
  • Ingår i: American Mineralogist. - 0003-004X .- 1945-3027. ; 98, s. 785-811
  • Tidskriftsartikel (refereegranskat)
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3.
  • Lenton, Timothy M., et al. (författare)
  • Earliest land plants created modern levels of atmospheric oxygen
  • 2016
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - 0027-8424 .- 1091-6490. ; 113:35, s. 9704-9709
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The progressive oxygenation of the Earth's atmosphere was pivotal to the evolution of life, but the puzzle of when and how atmospheric oxygen (O-2) first approached modern levels (similar to 21%) remains unresolved. Redox proxy data indicate the deep oceans were oxygenated during 435-392 Ma, and the appearance of fossil charcoal indicates O-2 &gt; 15-17% by 420-400 Ma. However, existing models have failed to predict oxygenation at this time. Here we show that the earliest plants, which colonized the land surface from similar to 470 Ma onward, were responsible for this mid-Paleozoic oxygenation event, through greatly increasing global organic carbon burialthe net long-term source of O-2. We use a trait-based ecophysiological model to predict that cryptogamic vegetation cover could have achieved similar to 30% of today's global terrestrial net primary productivity by similar to 445 Ma. Data from modern bryophytes suggests this plentiful early plant material had a much higher molar C:P ratio (similar to 2,000) than marine biomass (similar to 100), such that a given weathering flux of phosphorus could support more organic carbon burial. Furthermore, recent experiments suggest that early plants selectively increased the flux of phosphorus (relative to alkalinity) weathered from rocks. Combining these effects in a model of long-term biogeochemical cycling, we reproduce a sustained +2% increase in the carbonate carbon isotope (delta C-13) record by similar to 445 Ma, and predict a corresponding rise in O-2 to present levels by 420-400 Ma, consistent with geochemical data. This oxygen rise represents a permanent shift in regulatory regime to one where fire-mediated negative feedbacks stabilize high O-2 levels.</p>
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4.
  • Bosi, Ferdinando, et al. (författare)
  • On the application of the IMA-CNMNC dominant-valency rule to complex mineral compositions
  • 2019
  • Ingår i: Mineralogical magazine. - 0026-461X .- 1471-8022. ; 83:5, s. 627-632
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Mineral species should be identified by an end-member formula and by using the dominant-valency rule as recommended by the IMA–CNMNC. However, the dominant-end-member approach has also been used in the literature. These two approaches generally converge, but for some intermediate compositions, significant differences between the dominant-valency rule and the dominant end-member approach can be observed. As demonstrated for garnet-supergroup minerals, for example, the end-member approach is ambiguous, as end-member proportions strongly depend on the calculation sequence. For this reason, the IMA–CNMNC strongly recommends the use of the dominant-valency rule for mineral nomenclature, because it alone may lead to unambiguous mineral identification. Although the simple application of the dominant-valency rule is successful for the identification of many mineral compositions, sometimes it leads to unbalanced end-member formulae, due to the occurrence of a coupled heterovalent substitution at two sites along with a heterovalent substitution at a single site. In these cases, it may be useful to use the site-total-charge approach to identify the dominant root-charge arrangement on which to apply the dominant-constituent rule. The dominant-valency rule and the site-totalcharge approach may be considered two procedures complementary to each other for mineral identification. Their critical point is to find the most appropriate root-charge and atomic arrangements consistent with the overriding condition dictated by the end-member formula. These procedures were approved by the IMA−CNMNC in May 2019.</p><p></p>
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