SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Mints Miriam)
 

Search: WFRF:(Mints Miriam) > (2015-2019) > (2019) > Govorov Igor > Blood inflammatory ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Blood inflammatory and endothelial markers in women with von Willebrand disease

Govorov, Igor (author)
Karolinska Institutet
Bremme, Katarina (author)
Karolinska Institutet
Larsson, Anders (author)
Uppsala universitet,Klinisk kemi
show more...
Holmström, Margareta (author)
Karolinska Institutet
Komlichenko, Eduard (author)
Almazov National Medical Research Centre, Institution of Pediatrics and Perinatology, Saint-Petersburg, Russia
Chaireti, Roza (author)
Karolinska Institutet
Mints, Miriam (author)
Karolinska Institutet
show less...
 (creator_code:org_t)
2019-01-10
2019
English.
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:1
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Introduction: VWD-affected females often experience menorrhagia. Periodical fluctuations of the sex steroids during the menstrual cycle cause changes both in the coagulation and immune system. The aim of the current study was to assess the changes in selected inflammatory and endothelial markers in women with VWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with corresponding data from healthy controls.Materials and methods: The study group included 12 VWD-affected females with regular menstrual cycle, with none of them being prescribed hormone treatment. They were not pregnant or breastfeeding. The control group consisted of 102 healthy females, matched for age and BMI.Results: Within the VWD group, endostatin was higher during the follicular phase, compared to the luteal phase, although the difference was not significant (p = 0.062). sICAM-1 and IL-6 were higher in VWD-affected females, compared to the controls, sVCAM-1, cathepsin S and sP-selectin were lower (p<0.003 for all cases). The pattern was constant throughout the menstrual cycle.Conclusions: Higher levels of endostatin during early follicular phase could potentially predispose women with VWD to the development of heavy menstrual bleeding, due to antiangiogenic properties and ability to suppress several coagulation factors. Lower p-selectin levels in VWD group, compared to controls, may also contribute to the bleeding tendency. Changes in other proteins, involved in angiogenesis are hypothetically related to the formation of angiodysplasia—common complication of VWF deficiency. The latter statement requires confirmation in larger studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • PLOS ONE (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view