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1.
  • Ederle, Joerg, et al. (författare)
  • Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
  • 2010
  • Ingår i: The Lancet. - Elsevier. - 1474-547X. ; 375:9719, s. 985-997
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.16-2.45, p=0.006), Risks of any stroke (65 vs 35 events; HR 1.92, 1.27-2.89) and all-cause death (19 vs seven events; HR 2.76, 1.16-6.56) were higher in the stenting group than in the endarterectomy group. Three procedural myocardial infarctions were recorded in the stenting group, all of which were fatal, compared with four, all non-fatal, in the endarterectomy group. There was one event of cranial nerve palsy in the stenting group compared with 45 in the endarterectomy group. There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). Interpretation Completion of long-term follow-up is needed to establish the efficacy of carotid artery stenting compared with endarterectomy. In the meantime, carotid endarterectomy should remain the treatment of choice for patients suitable for surgery.
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2.
  • Munn-Chernoff, M. A., et al. (författare)
  • Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
  • 2020
  • Ingår i: Addiction Biology. - 1355-6215.
  • Tidskriftsartikel (refereegranskat)abstract
    • Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
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3.
  • Pulit, S. L., et al. (författare)
  • Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
  • 2018
  • Ingår i: Neurology-Genetics. - 2376-7839. ; 4:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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4.
  • Ablikim, M., et al. (författare)
  • Determination of the number of ψ(3686) events at BESIII
  • 2018
  • Ingår i: Chinese Physics C, High Energy Physics & Nuclear Physics. - 1674-1137 .- 0899-9996. ; 42:2
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The numbers of psi(3686) events accumulated by the BESIII detector for the data taken during 2009 and 2012 are determined to be (107.0 +/- 0.8)x10(6) and (341.1 +/- 2.1)x10(6), respectively, by counting inclusive hadronic events, where the uncertainties are systematic and the statistical uncertainties are negligible. The number of events for the sample taken in 2009 is consistent with that of the previous measurement. The total number of psi(3686) events for the two data taking periods is (448.1 +/- 2.9) x 10(6).</p><p></p>
5.
  • Ablikim, M., et al. (författare)
  • Precision measurements of B(D+ -&gt; mu(+)nu(mu)), the pseudoscalar decay constant fD+, and the quark mixing matrix element vertical bar V-cd vertical bar
  • 2014
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:5, s. 051104
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We report a measurement of the branching fraction B(D+ -&gt; mu(+)nu(mu)) = [3.71 +/- 0.19(stat) +/- 0.06(sys)] x 10(-4) based on 2.92 fb(-1) of data accumulated at root s = 3.773 GeV with the BESIII detector at the BEPCII collider. This measurement, in conjunction with the Cabibbo-Kobayashi-Maskawa matrix element vertical bar V-cd vertical bar determined from a global Standard Model fit, implies a value for the weak decay constant f(D+) = (203.2 +/- 5.3 +/- 1.8) MeV. Additionally, using this branching fraction measurement together with a lattice QCD prediction for f(D+), we find vertical bar V-cd vertical bar 0.2210 +/- 0.0058 +/- 0.0047. In either case, these are the most precise results for these quantities to date.</p>
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6.
  • Adare, A., et al. (författare)
  • Production of omega mesons in p plus p, d plus Au, Cu plus Cu, and Au plus Au collisions at root s(NN)=200 GeV
  • 2011
  • Ingår i: Physical Review C (Nuclear Physics). - American Physical Society. - 0556-2813. ; 84:4
  • Tidskriftsartikel (refereegranskat)abstract
    • The PHENIX experiment at the Relativistic Heavy Ion Collider has measured omega meson production via leptonic and hadronic decay channels in p + p, d + Au, Cu+ Cu, and Au + Au collisions at root s(NN) = 200 GeV. The invariant transverse momentum spectra measured in different decay modes give consistent results. Measurements in the hadronic decay channel in Cu Cu and Au + Au collisions show that. production has a suppression pattern at high transverse momentum, similar to that of pi(0) and eta in central collisions, but no suppression is observed in peripheral collisions. The nuclear modification factors, R-AA, are consistent in Cu + Cu and Au + Au collisions at similar numbers of participant nucleons.
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7.
  • Ablikim, M., et al. (författare)
  • Observation of e(+)e(-) -&gt; gamma X(3872) at BESIII
  • 2014
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:9, s. 092001
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>With data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies from 4.009 to 4.420 GeV, the process e(+)e(-) -&gt; gamma X(3872) is observed for the first time with a statistical significance of 6.3 sigma. The measured mass of the X(3872) is (3871.9 +/- 0.7(stat) +/- 0.2(syst)) MeV/c(2), in agreement with previous measurements. Measurements of the product of the cross section sigma[e(+)e(-) -&gt; gamma X(3872)] and the branching fraction B [X(3872) -&gt; pi(+)pi(-)J/psi] at center-of-mass energies 4.009, 4.229, 4.260, and 4.360 GeV are reported. Our measurements are consistent with expectations for the radiative transition process Y(4260) -&gt; gamma X(3872).</p>
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8.
  • Ablikim, M., et al. (författare)
  • Observation of electromagnetic Dalitz decays J/psi -&gt; Pe(+)e(-)
  • 2014
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:9
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Based on a sample of (225.3 +/- 2.8) x 10(6) J/psi events collected with the BESIII detector, the electromagnetic Dalitz decays of J/psi -&gt; Pe(+)e(-)(P = eta'/eta/pi(0)) are studied. By reconstructing the pseudoscalar mesons in various decay modes, the decays J/psi -&gt; eta'e(+)e(-), J/psi -&gt; eta e(+)e(-), and J/psi -&gt; pi(0)e(+)e(-) are observed for the first time. The branching fractions are determined to be B(J/psi -&gt; eta'e(+)e(-)) = (5.81 +/- 0.16 +/- 0.31) x 10(-5), B(J/psi -&gt; eta e(+)e(-)) = (1.16 +/- 0.07 +/- 0.06) x 10(-5), and B(J/psi -&gt; pi(0)e(+)e(-)) = (7.56 +/- 1.32 +/- 0.50) x 10(-7), where the first errors are statistical and the second ones systematic.</p>
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9.
  • Ablikim, M., et al. (författare)
  • Observation of eta' -&gt; pi(+) pi(-) pi(+) pi(-) and eta' -&gt; pi(+) pi(-) pi(0) pi(0)
  • 2014
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:25, s. 251801
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Using a sample of 1.3 x 10(9) J/psi events collected with the BESIII detector, we report the first observation of eta' -&gt; pi(+) pi(-) pi(+) pi(-) and eta' -&gt; pi(+) pi(-) pi(0) pi(0). The measured branching fractions are B(eta' -&gt; pi(+) pi(-) pi(+) pi(-)) = [8.53 +/- 0.69(stat.) +/- 0.64(syst.)] x 10(-5) and B(eta' -&gt; pi(+) pi(-) pi(0) pi(0)) = [1.82 +/- 0.35(stat.) +/- 0.18(syst.)] x 10(-4), which are consistent with theoretical predictions based on a combination of chiral perturbation theory and vector-meson dominance.</p>
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10.
  • Ablikim, M., et al. (författare)
  • Search for eta(c)(2S)h(c) -&gt; p(p)over-bar decays and measurements of the chi(cJ) -&gt; p(p)over-bar branching fractions
  • 2013
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:11, s. 112001
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Using a sample of 1.06 x 10(8)psi(3686) events collected with the BESIII detector at BEPCII, the decays eta(c)(2S) -&gt; p (p) over bar and h(c) -&gt; p (p) over bar are searched for, where eta(c)(2S) and h(c) are reconstructed in the decay chains psi(3686) -&gt; gamma eta(c)(2S), eta(c)(2S) -&gt; p (p) over bar and psi(3686) -&gt; pi(0)h(c), h(c) -&gt; p (p) over bar, respectively. No significant signals are observed. The upper limits of the product branching fractions are determined to be B(psi(3686) -&gt; gamma eta(c)(2S)) x B(eta(c)(2S) -&gt; p (p) over bar) &lt; 1.4 x 10(-6) and B(psi(3686) -&gt; pi(0)h(c)) x B(h(c) -&gt; p&lt;(p)over bar&gt;) &lt; 1.3 x 10(-7) at the 90% C.L.. The branching fractions for chi(cJ) -&gt; p&lt;(p)over bar&gt; (J = 0, 1, 2) are also measured to be (24.5 +/- 0.8 +/- 1.3, 8.6 +/- 0.5 +/- 0.5, 8.4 +/- 0.5 +/- 0.5) x 10(-5), which are the world's most precise measurements.</p>
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