SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Mitchell K) ;conttype:(scientificother)"

Sökning: WFRF:(Mitchell K) > Övrigt vetenskapligt/konstnärligt

  • Resultat 1-10 av 33
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Vazquez, SE, et al. (författare)
  • Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq
  • 2022
  • Ingår i: bioRxiv : the preprint server for biology. - : Cold Spring Harbor Laboratory. - 2692-8205.
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Phage Immunoprecipitation-Sequencing (PhIP-Seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-Seq for autoantigen discovery, including our previous work (Vazquez et al. 2020), current protocols are inherently difficult to scale to accommodate large cohorts of cases and importantly, healthy controls. Here, we develop and validate a high throughput extension of PhIP-seq in various etiologies of autoimmune and inflammatory diseases, including APS1, IPEX, RAG1/2 deficiency, Kawasaki Disease (KD), Multisystem Inflammatory Syndrome in Children (MIS-C), and finally, mild and severe forms of COVID19. We demonstrate that these scaled datasets enable machine-learning approaches that result in robust prediction of disease status, as well as the ability to detect both known and novel autoantigens, such as PDYN in APS1 patients, and intestinally expressed proteins BEST4 and BTNL8 in IPEX patients. Remarkably, BEST4 antibodies were also found in 2 patients with RAG1/2 deficiency, one of whom had very early onset IBD. Scaled PhIP-Seq examination of both MIS-C and KD demonstrated rare, overlapping antigens, including CGNL1, as well as several strongly enriched putative pneumonia-associated antigens in severe COVID19, including the endosomal protein EEA1. Together, scaled PhIP-Seq provides a valuable tool for broadly assessing both rare and common autoantigen overlap between autoimmune diseases of varying origins and etiologies.
  •  
7.
  • Bernal, Ximena E., et al. (författare)
  • Empowering Latina scientists
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
8.
  • Hoffmann, Thomas J, et al. (författare)
  • Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction
  • 2023
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (p≤5e-8) variants, 184 of which were novel. Most demonstrated evidence of replication in an independent cohort (n=95,768). Meta-analyzing discovery and replication (n=392,522) identified 447 variants, of which a further 111 were novel. Out-of-sample variance in PSA explained by our new polygenic risk score reached 16.9% (95% CI=16.1%-17.8%) in European ancestry, 9.5% (95% CI=7.0%-12.2%) in African ancestry, 18.6% (95% CI=15.8%-21.4%) in Hispanic/Latino, and 15.3% (95% CI=12.7%-18.1%) in Asian ancestry, and lower for higher age. Our study highlights how including proportionally more participants from underrepresented populations improves genetic prediction of PSA levels, with potential to personalize prostate cancer screening.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 33
Typ av publikation
tidskriftsartikel (14)
konferensbidrag (13)
annan publikation (5)
bokkapitel (1)
Typ av innehåll
övrigt vetenskapligt/konstnärligt  (33)Ta bort avgränsningen
Författare/redaktör
Mitchell, J. (6)
Mitchell, PB (4)
Landén, Mikael, 1966 (4)
Baune, BT (3)
Mitchell, A. (3)
Alda, Martin (3)
visa fler...
Vieta, Eduard (3)
Cosentino, F (3)
Grigelioniene, G (3)
Schofield, PR (3)
Martin, NG (3)
Lavebratt, Catharina (3)
Amare, Azmeraw T. (3)
Magnusson, B. (3)
Monteleone, Palmiero (3)
Luscher, TF (3)
Paneni, F. (3)
Vieta, E (3)
Schalling, Martin (3)
Schubert, Klaus Oliv ... (3)
Papiol, Sergi (3)
Heilbronner, Urs (3)
Degenhardt, Franzisk ... (3)
Hou, Liping (3)
Shekhtman, Tatyana (3)
Adli, Mazda (3)
Akula, Nirmala (3)
Akiyama, Kazufumi (3)
Ardau, Raffaella (3)
Arias, Bárbara (3)
Aubry, Jean-Michel (3)
Backlund, Lena (3)
Bellivier, Frank (3)
Bengesser, Susanne (3)
Marie-Claire, Cynthi ... (3)
Cervantes, Pablo (3)
Chen, Hsi-Chung (3)
Chillotti, Caterina (3)
Cichon, Sven (3)
Cruceanu, Cristiana (3)
Dalkner, Nina (3)
DePaulo, J Raymond (3)
Etain, Bruno (3)
Jamain, Stéphane (3)
Falkai, Peter (3)
Forstner, Andreas J (3)
Frisén, Louise (3)
Gard, Sébastien (3)
Grigoroiu-Serbanescu ... (3)
Grof, Paul (3)
visa färre...
Lärosäte
Karolinska Institutet (27)
Göteborgs universitet (5)
Lunds universitet (3)
Uppsala universitet (1)
Stockholms universitet (1)
Chalmers tekniska högskola (1)
Språk
Engelska (33)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (8)
Naturvetenskap (2)
Samhällsvetenskap (2)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy