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Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.

Skibola, Christine F (author)
Berndt, Sonja I (author)
Vijai, Joseph (author)
show more...
Conde, Lucia (author)
Wang, Zhaoming (author)
Yeager, Meredith (author)
de Bakker, Paul I W (author)
Birmann, Brenda M (author)
Vajdic, Claire M (author)
Foo, Jia-Nee (author)
Bracci, Paige M (author)
Vermeulen, Roel C H (author)
Slager, Susan L (author)
de Sanjose, Silvia (author)
Wang, Sophia S (author)
Linet, Martha S (author)
Salles, Gilles (author)
Lan, Qing (author)
Severi, Gianluca (author)
Hjalgrim, Henrik (author)
Karolinska Institutet
Lightfoot, Tracy (author)
Melbye, Mads (author)
Gu, Jian (author)
Ghesquières, Hervé (author)
Link, Brian K (author)
Morton, Lindsay M (author)
Holly, Elizabeth A (author)
Smith, Alex (author)
Tinker, Lesley F (author)
Teras, Lauren R (author)
Kricker, Anne (author)
Becker, Nikolaus (author)
Purdue, Mark P (author)
Spinelli, John J (author)
Zhang, Yawei (author)
Giles, Graham G (author)
Vineis, Paolo (author)
Monnereau, Alain (author)
Bertrand, Kimberly A (author)
Albanes, Demetrius (author)
Zeleniuch-Jacquotte, Anne (author)
Gabbas, Attilio (author)
Chung, Charles C (author)
Burdett, Laurie (author)
Hutchinson, Amy (author)
Lawrence, Charles (author)
Montalvan, Rebecca (author)
Liang, Liming (author)
Huang, Jinyan (author)
Ma, Baoshan (author)
Liu, Jianjun (author)
Adami, Hans-Olov (author)
Glimelius, Bengt (author)
Uppsala universitet,Enheten för onkologi
Ye, Yuanqing (author)
Nowakowski, Grzegorz S (author)
Dogan, Ahmet (author)
Thompson, Carrie A (author)
Habermann, Thomas M (author)
Novak, Anne J (author)
Liebow, Mark (author)
Witzig, Thomas E (author)
Weiner, George J (author)
Schenk, Maryjean (author)
Hartge, Patricia (author)
De Roos, Anneclaire J (author)
Cozen, Wendy (author)
Zhi, Degui (author)
Akers, Nicholas K (author)
Riby, Jacques (author)
Smith, Martyn T (author)
Lacher, Mortimer (author)
Villano, Danylo J (author)
Maria, Ann (author)
Roman, Eve (author)
Kane, Eleanor (author)
Karolinska Institutet
Jackson, Rebecca D (author)
North, Kari E (author)
Diver, W Ryan (author)
Turner, Jenny (author)
Armstrong, Bruce K (author)
Benavente, Yolanda (author)
Boffetta, Paolo (author)
Brennan, Paul (author)
Foretova, Lenka (author)
Maynadie, Marc (author)
Staines, Anthony (author)
McKay, James (author)
Brooks-Wilson, Angela R (author)
Zheng, Tongzhang (author)
Holford, Theodore R (author)
Chamosa, Saioa (author)
Kaaks, Rudolph (author)
Kelly, Rachel S (author)
Ohlsson, Bodil (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Travis, Ruth C (author)
Weiderpass, Elisabete (author)
Karolinska Institutet
Clavel, Jacqueline (author)
Giovannucci, Edward (author)
Kraft, Peter (author)
Virtamo, Jarmo (author)
Mazza, Patrizio (author)
Cocco, Pierluigi (author)
Ennas, Maria Grazia (author)
Chiu, Brian C H (author)
Fraumeni, Joseph F (author)
Nieters, Alexandra (author)
Offit, Kenneth (author)
Wu, Xifeng (author)
Cerhan, James R (author)
Smedby, Karin E (author)
Chanock, Stephen J (author)
Rothman, Nathaniel (author)
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 (creator_code:org_t)
Elsevier BV, 2014
2014
English.
In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 95:4, s. 462-471
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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By the author/editor
Skibola, Christi ...
Berndt, Sonja I
Vijai, Joseph
Conde, Lucia
Wang, Zhaoming
Yeager, Meredith
show more...
de Bakker, Paul ...
Birmann, Brenda ...
Vajdic, Claire M
Foo, Jia-Nee
Bracci, Paige M
Vermeulen, Roel ...
Slager, Susan L
de Sanjose, Silv ...
Wang, Sophia S
Linet, Martha S
Salles, Gilles
Lan, Qing
Severi, Gianluca
Hjalgrim, Henrik
Lightfoot, Tracy
Melbye, Mads
Gu, Jian
Ghesquières, Her ...
Link, Brian K
Morton, Lindsay ...
Holly, Elizabeth ...
Smith, Alex
Tinker, Lesley F
Teras, Lauren R
Kricker, Anne
Becker, Nikolaus
Purdue, Mark P
Spinelli, John J
Zhang, Yawei
Giles, Graham G
Vineis, Paolo
Monnereau, Alain
Bertrand, Kimber ...
Albanes, Demetri ...
Zeleniuch-Jacquo ...
Gabbas, Attilio
Chung, Charles C
Burdett, Laurie
Hutchinson, Amy
Lawrence, Charle ...
Montalvan, Rebec ...
Liang, Liming
Huang, Jinyan
Ma, Baoshan
Liu, Jianjun
Adami, Hans-Olov
Glimelius, Bengt
Ye, Yuanqing
Nowakowski, Grze ...
Dogan, Ahmet
Thompson, Carrie ...
Habermann, Thoma ...
Novak, Anne J
Liebow, Mark
Witzig, Thomas E
Weiner, George J
Schenk, Maryjean
Hartge, Patricia
De Roos, Annecla ...
Cozen, Wendy
Zhi, Degui
Akers, Nicholas ...
Riby, Jacques
Smith, Martyn T
Lacher, Mortimer
Villano, Danylo ...
Maria, Ann
Roman, Eve
Kane, Eleanor
Jackson, Rebecca ...
North, Kari E
Diver, W Ryan
Turner, Jenny
Armstrong, Bruce ...
Benavente, Yolan ...
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
Staines, Anthony
McKay, James
Brooks-Wilson, A ...
Zheng, Tongzhang
Holford, Theodor ...
Chamosa, Saioa
Kaaks, Rudolph
Kelly, Rachel S
Ohlsson, Bodil
Travis, Ruth C
Weiderpass, Elis ...
Clavel, Jacqueli ...
Giovannucci, Edw ...
Kraft, Peter
Virtamo, Jarmo
Mazza, Patrizio
Cocco, Pierluigi
Ennas, Maria Gra ...
Chiu, Brian C H
Fraumeni, Joseph ...
Nieters, Alexand ...
Offit, Kenneth
Wu, Xifeng
Cerhan, James R
Smedby, Karin E
Chanock, Stephen ...
Rothman, Nathani ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
American Journal ...
By the university
Lund University
Karolinska Institutet
Uppsala University

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