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1.	Sims, R, et al. (author) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:9, s. 1373- Journal article (peer-reviewed)
2.	Lambert, JC, et al. (author) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease 2013 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:12, s. 1452-U206 Journal article (peer-reviewed)
3.	Plubell, Deanna L., et al. (author) Putting Humpty Dumpty Back Together Again : What Does Protein Quantification Mean in Bottom-Up Proteomics? br 2022 In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 21:4, s. 891-898 Journal article (peer-reviewed)abstract Bottom-up proteomics provides peptide measurements and has beeninvaluable for moving proteomics into large-scale analyses. Commonly, a singlequantitative value is reported for each protein-coding gene by aggregating peptidequantities into protein groups following protein inference or parsimony. However, giventhe complexity of both RNA splicing and post-translational protein modification, it isoverly simplistic to assume that all peptides that map to a singular protein-coding genewill demonstrate the same quantitative response. By assuming that all peptides from aprotein-coding sequence are representative of the same protein, we may miss thediscovery of important biological differences. To capture the contributions of existingproteoforms, we need to reconsider the practice of aggregating protein values to a singlequantity per protein-coding gene.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Ruiz, A. (2); Schmidt, H. (2); Brayne, C (2); Brown, K. (2); Williams, J (2); Gu, W. (2); show more...; Bennett, DA (2); Mancuso, M. (2); Amin, N (2); van Duijn, CM (2); Boada, M. (2); Pilotto, A (2); Spalletta, G (2); Pastor, P (2); Rujescu, D (2); Ingelsson, Martin (2); Lannfelt, Lars (2); Soininen, H (2); Hiltunen, M (2); Chouraki, V (2); Seshadri, S (2); Bis, JC (2); Smith, AV (2); Amouyel, P (2); De Jager, PL (2); Foroud, TM (2); Gudnason, V (2); Hardy, J (2); Hofman, A (2); Lopez, OL (2); Lovestone, S (2); Mecocci, P (2); Mosley, TH (2); Nothen, MM (2); Psaty, BM (2); Rotter, JI (2); Schmidt, R (2); Tzourio, C (2); Vardarajan, BN (2); Launer, LJ (2); Ikram, MA (2); Fratiglioni, L (2); Tsolaki, M (2); Boerwinkle, E (2); Jones, L (2); Ramirez, A (2); Thomas, C (2); Berr, C (2); Ritchie, K (2); Clarimón, J. (2); show less...

University: Uppsala University (2); Stockholm University (2); Karolinska Institutet (2); Royal Institute of Technology (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (3)Undo refine; Medical and Health Sciences (1)

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