| 1. |
- Ingegnoli, Francesca, et al.
(author)
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A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study
- 2015
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In: Microvascular Research. - : Elsevier BV. - 1095-9319 .- 0026-2862. ; 102, s. 19-24
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Journal article (peer-reviewed)abstract
- Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% Cl 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% Cl 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of sderoderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue. (C) 2015 Elsevier Inc. All rights reserved.
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| 2. |
- Ingegnoli, Francesca, et al.
(author)
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Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database
- 2013
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In: Microvascular Research. - : Elsevier BV. - 1095-9319 .- 0026-2862. ; 89, s. 122-128
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Journal article (peer-reviewed)abstract
- Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48% of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The "early" and "active" scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the "late" scleroderma pattern was found more frequently in the more severe forms of the disease. Conclusion: These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement. (C) 2013 Elsevier Inc. All rights reserved.
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| 3. |
- Suszko, Tomasz, et al.
(author)
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Quasi-amorphous, nanostructural CoCrMoC/a-C:H coatings deposited by reactive magnetron sputtering
- 2019
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In: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 378
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Journal article (peer-reviewed)abstract
- CoCrMo-C coatings have been deposited on CoCrMo ISO 5832-12 alloy substrates by reactive magnetron sputtering from targets of the same alloy in the C2H2/Ar atmosphere. Their structure evolution with increasing carbon content as well as chemical and phase composition were investigated by X-ray diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy. Hardness, Young’s modulus, and tribological properties in ambient air were studied. Results show that microstructure of deposits evolves from biphasic, containing γ (fcc) and ε (hcp) metallic phases for low carbon content, through nanocrystalline and amorphous for carbon content between 10 and 20 at.%, to quasi-amorphous nanostructural for even higher content of carbon. Segregation of amorphous carbon leads to the formation of self-organized tubular nanostructure for coatings containing more than 30 at.% of carbon. Introduction of carbon into CoCrMo alloy results in a significant increase of hardness up to 14 GPa and improvement of load-bearing capacity which reached 120 MPa. Compared to uncoated CoCrMo substrate, deposited coatings with high carbon content exhibited superior tribological properties with low friction coefficient around 0.2 and wear rate about 2 × 10−15 m3/N/m.
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