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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Franke, Andre (author)
McGovern, Dermot P B (author)
Barrett, Jeffrey C (author)
show more...
Wang, Kai (author)
Radford-Smith, Graham L (author)
Ahmad, Tariq (author)
Lees, Charlie W (author)
Balschun, Tobias (author)
Lee, James (author)
Roberts, Rebecca (author)
Anderson, Carl A (author)
Bis, Joshua C (author)
Bumpstead, Suzanne (author)
Ellinghaus, David (author)
Festen, Eleonora M (author)
Georges, Michel (author)
Green, Todd (author)
Haritunians, Talin (author)
Jostins, Luke (author)
Latiano, Anna (author)
Mathew, Christopher G (author)
Montgomery, Grant W (author)
Prescott, Natalie J (author)
Raychaudhuri, Soumya (author)
Rotter, Jerome I (author)
Schumm, Philip (author)
Sharma, Yashoda (author)
Simms, Lisa A (author)
Taylor, Kent D (author)
Whiteman, David (author)
Wijmenga, Cisca (author)
Baldassano, Robert N (author)
Barclay, Murray (author)
Bayless, Theodore M (author)
Brand, Stephan (author)
Büning, Carsten (author)
Cohen, Albert (author)
Colombel, Jean-Frederick (author)
Cottone, Mario (author)
Stronati, Laura (author)
Denson, Ted (author)
De Vos, Martine (author)
D'Inca, Renata (author)
Dubinsky, Marla (author)
Karolinska Institutet
Edwards, Cathryn (author)
Florin, Tim (author)
Franchimont, Denis (author)
Gearry, Richard (author)
Glas, Jürgen (author)
Van Gossum, Andre (author)
Guthery, Stephen L (author)
Halfvarson, Jonas, 1970- (author)
Örebro universitet,Hälsoakademin
Verspaget, Hein W (author)
Hugot, Jean-Pierre (author)
Karban, Amir (author)
Laukens, Debby (author)
Lawrance, Ian (author)
Lemann, Marc (author)
Levine, Arie (author)
Libioulle, Cecile (author)
Louis, Edouard (author)
Mowat, Craig (author)
Newman, William (author)
Panés, Julián (author)
Phillips, Anne (author)
Proctor, Deborah D (author)
Regueiro, Miguel (author)
Russell, Richard (author)
Rutgeerts, Paul (author)
Sanderson, Jeremy (author)
Sans, Miquel (author)
Seibold, Frank (author)
Steinhart, A Hillary (author)
Stokkers, Pieter C F (author)
Torkvist, Leif (author)
Karolinska Institutet
Kullak-Ublick, Gerd (author)
Wilson, David (author)
Walters, Thomas (author)
Targan, Stephan R (author)
Brant, Steven R (author)
Rioux, John D (author)
D'Amato, Mauro (author)
Weersma, Rinse K (author)
Kugathasan, Subra (author)
Griffiths, Anne M (author)
Mansfield, John C (author)
Vermeire, Severine (author)
Duerr, Richard H (author)
Silverberg, Mark S (author)
Satsangi, Jack (author)
Schreiber, Stefan (author)
Cho, Judy H (author)
Annese, Vito (author)
Hakonarson, Hakon (author)
Daly, Mark J (author)
Parkes, Miles (author)
show less...
 (creator_code:org_t)
2010-11-21
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Medicine
Medicin

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Franke, Andre
McGovern, Dermot ...
Barrett, Jeffrey ...
Wang, Kai
Radford-Smith, G ...
Ahmad, Tariq
show more...
Lees, Charlie W
Balschun, Tobias
Lee, James
Roberts, Rebecca
Anderson, Carl A
Bis, Joshua C
Bumpstead, Suzan ...
Ellinghaus, Davi ...
Festen, Eleonora ...
Georges, Michel
Green, Todd
Haritunians, Tal ...
Jostins, Luke
Latiano, Anna
Mathew, Christop ...
Montgomery, Gran ...
Prescott, Natali ...
Raychaudhuri, So ...
Rotter, Jerome I
Schumm, Philip
Sharma, Yashoda
Simms, Lisa A
Taylor, Kent D
Whiteman, David
Wijmenga, Cisca
Baldassano, Robe ...
Barclay, Murray
Bayless, Theodor ...
Brand, Stephan
Büning, Carsten
Cohen, Albert
Colombel, Jean-F ...
Cottone, Mario
Stronati, Laura
Denson, Ted
De Vos, Martine
D'Inca, Renata
Dubinsky, Marla
Edwards, Cathryn
Florin, Tim
Franchimont, Den ...
Gearry, Richard
Glas, Jürgen
Van Gossum, Andr ...
Guthery, Stephen ...
Halfvarson, Jona ...
Verspaget, Hein ...
Hugot, Jean-Pier ...
Karban, Amir
Laukens, Debby
Lawrance, Ian
Lemann, Marc
Levine, Arie
Libioulle, Cecil ...
Louis, Edouard
Mowat, Craig
Newman, William
Panés, Julián
Phillips, Anne
Proctor, Deborah ...
Regueiro, Miguel
Russell, Richard
Rutgeerts, Paul
Sanderson, Jerem ...
Sans, Miquel
Seibold, Frank
Steinhart, A Hil ...
Stokkers, Pieter ...
Torkvist, Leif
Kullak-Ublick, G ...
Wilson, David
Walters, Thomas
Targan, Stephan ...
Brant, Steven R
Rioux, John D
D'Amato, Mauro
Weersma, Rinse K
Kugathasan, Subr ...
Griffiths, Anne ...
Mansfield, John ...
Vermeire, Severi ...
Duerr, Richard H
Silverberg, Mark ...
Satsangi, Jack
Schreiber, Stefa ...
Cho, Judy H
Annese, Vito
Hakonarson, Hako ...
Daly, Mark J
Parkes, Miles
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Nature Genetics
By the university
Örebro University
Karolinska Institutet

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