y Effects of Serelaxin in Patients with Acute Heart Failure

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y Effects of Serelaxin in Patients with Acute Heart Failure

Metra, Marco (author): Univ Brescia, Cardiol, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy

Teerlink, John R. (author): Univ Calif San Francisco, Sect Cardiol, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94143 USA;Univ Calif San Francisco, Sch Med, San Francisco, CA USA

Cotter, Gad (author): Duke Univ, Sch Med, Momentum Res, Durham, NC USA

Davison, Beth A. (author): Duke Univ, Sch Med, Momentum Res, Durham, NC USA

Felker, G. Michael (author): Duke Univ, Sch Med, Div Cardiol, Durham, NC USA

Filippatos, Gerasimos (author): Univ Cyprus, Sch Med, Nicosia, Cyprus;Univ Athens, Sch Med, Athens, Greece

Greenberg, Barry H. (author): Univ Calif San Diego, Div Cardiol, La Jolla, CA 92093 USA

Pang, Peter S. (author): Indiana Univ Sch Med, Dept Emergency Med, Indianapolis, IN 46202 USA;Regenstrief Inst Hlth Care, Indianapolis, IN 46202 USA

Ponikowski, Piotr (author): Med Univ, Mil Hosp, Dept Heart Dis, Wroclaw, Poland

Voors, Adriaan A. (author): Univ Groningen, Groningen, Netherlands

Adams, Kirkwood F. (author): Univ N Carolina, Chapel Hill, NC 27515 USA

Anker, Stefan D. (author): Charite Univ Med Berlin, Partner Site Berlin, Dept Internal Med & Cardiol, Campus Virchow Klinikum,German Ctr Cardiovasc Res, Berlin, Germany;Charite Univ Med Berlin, Berlin Inst Hlth Ctr Regenerat Therapies, Campus Virchow Klinikum, Berlin, Germany

Arias-Mendoza, Alexandra (author): Inst Nacl Cardiol Ignacio Chavez, Coronary Care & Emergency Dept, Mexico City, DF, Mexico

Avendano, Patricio (author): Hosp Clin Fuerza Aerea Chile, Las Condes, Chile

Bacal, Fernando (author): Univ Sao Paulo, Heart Inst InCor, Heart Transplantat Dept, Sao Paulo, Brazil;Hosp Israelita Albert Einstein, Sao Paulo, Brazil

Boehm, Michael (author): Saarland Univ, Univ Klinikum Saarlandes Homburg, Homburg, Germany

Bortman, Guillermo (author): Sanat Trinidad Mitre, Buenos Aires, DF, Argentina

Cleland, John G. F. (author): Univ Glasgow, Robertson Ctr Biostat & Clin Trials, Glasgow, Lanark, Scotland;Imperial Coll, Natl Heart & Lung Inst, London, England

Cohen-Solal, Alain (author): Hop Lariboisiere, Cardiol Dept, Paris, France;Univ Paris, Paris, France

Crespo-Leiro, Maria G. (author): Univ A Coruna, Complejo Hosp Univ A Coruna, Ctr Invest Biomed Red Enfermedades Cardiovasc, La Coruna, Spain

Dorobantu, Maria (author): Carol Davila Univ Med & Pharm, Bucharest, Romania

Echeverria, Luis E. (author): Fdn Cardiovasc Colombia, Heart Failure & Heart Transplant Clin, Floridablanca, Colombia

Ferrari, Roberto (author): Univ Ferrara, Ctr Cardiol, Ferrara, Italy;Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy

Goland, Sorel (author): Hebrew Univ Jerusalem, Kaplan Med Ctr, Heart Inst, Jerusalem, Israel

Goncalvesova, Eva (author): Natl Cardiovasc Inst, Bratislava, Slovakia

Goudev, Assen (author): Med Univ Sofia, Tzaritza Ioanna Univ Hosp, Sofia, Bulgaria

Kober, Lars (author): Univ Copenhagen, Rigshosp, Dept Cardiol, Copenhagen, Denmark

Lema-Osores, Juan (author): Hosp Nacl Arzobispo Loayza, Internal Med Cardiol, Internal Med Dept, Lima, Peru

Levy, Phillip D. (author): Wayne State Univ, Sch Med, Detroit, MI USA;Cardiovasc Res Inst, Detroit, MI USA

McDonald, Kenneth (author): Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland;Univ Coll Dublin, St Vincents Univ Hosp, Dublin, Ireland

Manga, Pravin (author): Univ Witwatersrand, Dept Internal Med, Johannesburg, South Africa

Merkely, Bela (author): Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary

Mueller, Christian (author): Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland;Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland

Pieske, Burkert (author): Charite Univ Med Berlin, Partner Site Berlin, Dept Internal Med & Cardiol, Campus Virchow Klinikum,German Ctr Cardiovasc Res, Berlin, Germany

Silva-Cardoso, Jose (author): Univ Porto, Med Sch, Sao Joao Med Ctr, CINTESIS, Porto, Portugal

Spinar, Jindrich (author)

Squire, Iain (author): Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, Biomed Res Ctr, Natl Inst Hlth Res, Leicester, Leics, England

Stepinska, Janina (author)

Van Mieghem, Walter (author): Univ Hasselt, Hasselt, Belgium

von Lewinski, Dirk (author): Med Univ Graz, Dept Internal Med, Div Cardiol, Graz, Austria

Wikström, Gerhard (author): Uppsala universitet,Kardiologi

Yilmaz, Mehmet B. (author): Dokuz Eylul Univ, Dept Cardiol, Fac Med, Izmir, Turkey

Hagner, Nicole (author): Novartis Pharmaceut, E Hanover, NJ USA

Holbro, Thomas (author): Novartis Pharmaceut, Basel, Switzerland;Novartis Pharmaceut, E Hanover, NJ USA

Hua, Tsushung A. (author): Novartis Pharmaceut, E Hanover, NJ USA

Sabarwal, Shalini V. (author): Novartis Pharmaceut, E Hanover, NJ USA

Severin, Thomas (author): Novartis Pharmaceut, Basel, Switzerland

Szecsody, Peter (author): Novartis Pharmaceut, Basel, Switzerland

Gimpelewicz, Claudio (author): Novartis Pharmaceut, Basel, Switzerland

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MASSACHUSETTS MEDICAL SOC, 2019
2019
English.
In: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 381:8, s. 716-726

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BackgroundSerelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure. MethodsIn this multicenter, double-blind, placebo-controlled, event-driven trial, we enrolled patients who were hospitalized for acute heart failure and had dyspnea, vascular congestion on chest radiography, increased plasma concentrations of natriuretic peptides, mild-to-moderate renal insufficiency, and a systolic blood pressure of at least 125 mm Hg, and we randomly assigned them within 16 hours after presentation to receive either a 48-hour intravenous infusion of serelaxin (30 mu g per kilogram of body weight per day) or placebo, in addition to standard care. The two primary end points were death from cardiovascular causes at 180 days and worsening heart failure at 5 days.ResultsA total of 6545 patients were included in the intention-to-treat analysis. At day 180, death from cardiovascular causes had occurred in 285 of the 3274 patients (8.7%) in the serelaxin group and in 290 of the 3271 patients (8.9%) in the placebo group (hazard ratio, 0.98; 95% confidence interval [CI], 0.83 to 1.15; P=0.77). At day 5, worsening heart failure had occurred in 227 patients (6.9%) in the serelaxin group and in 252 (7.7%) in the placebo group (hazard ratio, 0.89; 95% CI, 0.75 to 1.07; P=0.19). There were no significant differences between the groups in the incidence of death from any cause at 180 days, the incidence of death from cardiovascular causes or rehospitalization for heart failure or renal failure at 180 days, or the length of the index hospital stay. The incidence of adverse events was similar in the two groups.ConclusionsIn this trial involving patients who were hospitalized for acute heart failure, an infusion of serelaxin did not result in a lower incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days than placebo. (Funded by Novartis Pharma; RELAX-AHF-2 ClinicalTrials.gov number, NCT01870778.) In a randomized trial, 6545 patients with acute heart failure were assigned to either serelaxin or placebo in addition to standard care. There were no significant differences between the two groups in the incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days.

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By the author/editor: Metra, Marco; Teerlink, John R ...; Cotter, Gad; Davison, Beth A.; Felker, G. Micha ...; Filippatos, Gera ...; show more...; Greenberg, Barry ...; Pang, Peter S.; Ponikowski, Piot ...; Voors, Adriaan A ...; Adams, Kirkwood ...; Anker, Stefan D.; Arias-Mendoza, A ...; Avendano, Patric ...; Bacal, Fernando; Boehm, Michael; Bortman, Guiller ...; Cleland, John G. ...; Cohen-Solal, Ala ...; Crespo-Leiro, Ma ...; Dorobantu, Maria; Echeverria, Luis ...; Ferrari, Roberto; Goland, Sorel; Goncalvesova, Ev ...; Goudev, Assen; Kober, Lars; Lema-Osores, Jua ...; Levy, Phillip D.; McDonald, Kennet ...; Manga, Pravin; Merkely, Bela; Mueller, Christi ...; Pieske, Burkert; Silva-Cardoso, J ...; Spinar, Jindrich; Squire, Iain; Stepinska, Janin ...; Van Mieghem, Wal ...; von Lewinski, Di ...; Wikström, Gerhar ...; Yilmaz, Mehmet B ...; Hagner, Nicole; Holbro, Thomas; Hua, Tsushung A.; Sabarwal, Shalin ...; Severin, Thomas; Szecsody, Peter; Gimpelewicz, Cla ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: New England Jour ...

By the university: Uppsala University

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y Effects of Serelaxin in Patients with Acute Heart Failure

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