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1.	Azimzadeh, Omid, et al. (author) PPAR Alpha: A Novel Radiation Target in Locally Exposed Mus musculus Heart Revealed by Quantitative Proteomics 2013 In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 12:6, s. 2700-2714 Journal article (peer-reviewed)abstract Radiation exposure of the thorax is associated with a markedly increased risk of cardiac morbidity and mortality with a latency period of decades. Although many studies have confirmed the damaging effect of ionizing radiation on the myocardium and cardiac endothelial structure and function, the molecular mechanism behind this damage is not yet elucidated. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a transcriptional regulator of lipid metabolism in heart tissue, has recently received great attention in the development of cardiovascular disease. The goal of this study was to investigate radiation-induced cardiac damage in general and the role of PPAR alpha in this process in particular. C57BL/6 mice received local heart irradiation with X-ray doses of 8 and 16 gray (Gy) at the age of 8 weeks. The mice were sacrificed 16 weeks later. Radiation-induced changes in the cardiac proteome were quantified using the Isotope Coded Protein Label (ICPL) method followed by mass spectrometry and software analysis. Significant alterations were observed in proteins involved in lipid metabolism and oxidative phosphorylation. Ionizing radiation markedly changed the phosphorylation and ubiquitination status of PPAR alpha. This was reflected as decreased expression of its target genes involved in energy metabolism and mitochondrial respiratory chain confirming the proteomics data. This study suggests that persistent alteration of cardiac metabolism due to impaired PPAR alpha activity contributes to the heart pathology after radiation.
2.	Kepp, O, et al. (author) Consensus guidelines for the detection of immunogenic cell death 2014 In: Oncoimmunology. - : Informa UK Limited. - 2162-4011 .- 2162-402X. ; 3:9, s. e955691- Research review (peer-reviewed)

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Type of publication: journal article (1); research review (1)

Type of content: peer-reviewed (2)

Author/Editor: Huang, X. (1); Madeo, F (1); Kroemer, G (1); Mignot, G (1); Agostinis, P (1); Martins, I (1); show more...; Garg, A (1); Kepp, O (1); Galluzzi, L (1); Demaria, S (1); Loi, S (1); Manfredi, AA (1); Cirone, M (1); Faggioni, A (1); Proietti, E. (1); Apetoh, L (1); Smyth, MJ (1); Lugli, E (1); Tartour, E (1); PanaretakiS, T (1); Zitvogel, L (1); Ueffing, Marius (1); Aranda, F (1); Bloy, N (1); Senovilla, L (1); Rovere-Querini, P (1); Galon, J (1); Azimzadeh, Omid (1); Yentrapalli, Ramesh, ... (1); Barjaktarovic, Zarko (1); Atkinson, Michael J. (1); Tapio, Soile (1); Sievert, Wolfgang (1); Sarioglu, Hakan (1); Sriharshan, Arundhat ... (1); Janik, Dirk (1); Aichler, Michaela (1); Multhoff, Gabriele (1); Palombo, F (1); Vacchelli, E (1); Buque, A (1); Mavilio, D. (1); Dini, L (1); Breckpot, K (1); Zong, WX (1); Pol, J (1); Stagg, J (1); Hemminki, A (1); Ghiringhelli, F (1); Herrmann, M (1); show less...

University: Stockholm University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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