Sökning: WFRF:(Munck Wikland Eva)
> Elmberger Goran >
Phylogenetic analys...
Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis
-
- Wangsa, Darawalee (författare)
- NCI, MD 20892 USA; Karolinska University Hospital, Sweden
-
- Akhter Chowdhury, Salim (författare)
- Carnegie Mellon University, PA 15213 USA; Carnegie Mellon University, PA 15213 USA
-
- Ryott, Michael (författare)
- Sophiahemmet Hospital, Sweden
-
visa fler...
-
- Michael Gertz, E. (författare)
- NIH, MD 20892 USA
-
- Elmberger, Goran (författare)
- Örebro University Hospital, Sweden
-
- Auer, Gert (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Åvall Lundqvist, Elisabeth (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Karolinska University Hospital, Sweden
-
- Kueffer, Stefan (författare)
- University of Medical Centre Gottingen, Germany
-
- Stroebel, Philipp (författare)
- University of Medical Centre Gottingen, Germany
-
- Schaeffer, Alejandro A. (författare)
- NIH, MD 20892 USA
-
- Schwartz, Russell (författare)
- Carnegie Mellon University, PA 15213 USA; Carnegie Mellon University, PA 15213 USA
-
- Munck-Wikland, Eva (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
-
- Ried, Thomas (författare)
- NCI, MD 20892 USA
-
- Heselmeyer-Haddad, Kerstin (författare)
- NCI, MD 20892 USA
-
visa färre...
-
(creator_code:org_t)
- 2015-08-28
- 2016
- Engelska.
-
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 138:1, s. 98-109
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of sixty-five OTSCC patients (Stage I, n=15; Stage II, n=30; Stage III, n=7; Stage IV, n=13). Unsupervised hierarchical clustering of the FISH data distinguished three clusters related to smoking status. Copy number increases of all five markers were found to be correlated to non-smoking habits, while smokers in this cohort had low-level copy number gains. Using the phylogenetic modeling software FISHtrees, we constructed models of tumor progression for each patient based on the four gene probes. Then, we derived test statistics on the models that are significant predictors of disease-free and overall survival, independent of tumor stage and smoking status in multivariate analysis. The patients whose tumors were modeled as progressing by a more diverse distribution of copy number changes across the four genes have poorer prognosis. This is consistent with the view that multiple genetic pathways need to become deregulated in order for cancer to progress. Whats new? Oral tongue squamous cell carcinoma (OTSCC) is a rare head and neck cancer that typically is asymptomatic in early stages. Hence, in order to improve prognosis in OTSCC, predictive biomarkers that are independent of tumor stage must be identified. Here, using four fluorescence in situ hybridization (FISH) gene probes and the software FISHtrees, phylogenetic tree models of tumor progression in OTSCC patients were constructed. Analyses of the models showed that the more diverse the changes within the four marker genes, the worse the outcome in OTSCC. The markers predicted survival independent of smoking behavior and tumor stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- oral tongue cancer
- FISH
- genetic markers
- phylogenetic modeling
- HPV
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wangsa, Darawale ...
-
Akhter Chowdhury ...
-
Ryott, Michael
-
Michael Gertz, E ...
-
Elmberger, Goran
-
Auer, Gert
-
visa fler...
-
Åvall Lundqvist, ...
-
Kueffer, Stefan
-
Stroebel, Philip ...
-
Schaeffer, Aleja ...
-
Schwartz, Russel ...
-
Munck-Wikland, E ...
-
Ried, Thomas
-
Heselmeyer-Hadda ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet