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- Naeser, Ylva, et al.
(författare)
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TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Melanoma
- 2020
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe incidence of cutaneous malignant melanoma (CMM) is increasing worldwide. In Sweden, over 4600 cases were diagnosed in 2018. The prognosis after radical surgery varies considerably with tumor stage. In recent years, new treatment options have become available for metastatic CMM. Early onset of treatment seems to improve outcome, which suggests that early detection of recurrent disease should be beneficial. Consequently, in several countries imaging is a part of the routine follow-up program after surgery of high risk CMM. However, imaging has drawbacks, including resources required (costs, personnel, equipment) and the radiation exposure. Furthermore, many patients experience anxiety in waiting for the imaging results and investigations of irrelevant findings is another factor that also could cause worry and lead to decreased quality of life. Hence, the impact of imaging in this setting is important to address and no randomized study has previously been conducted. The Swedish national guidelines stipulate follow-up for 3years by clinical examinations only.MethodsThe TRIM study is a prospective randomized multicenter trial evaluating the potential benefit of imaging and blood tests during follow-up after radical surgery for high-risk CMM, compared to clinical examinations only. Primary endpoint is overall survival (OS) at 5years. Secondary endpoints are survival from diagnosis of relapse and health-related quality of life (HRQoL). Eligible for inclusion are patients radically operated for CMM stage IIB-C or III with sufficient renal function for iv contrast-enhanced CT and who are expected to be fit for treatment in case of recurrence. The planned number of patients is >1300. Patients are randomized to clinical examinations for 3years +/- whole-body imaging with CT or FDG-PET/CT and laboratory tests including S100B protein and LDH. This academic study is supported by the Swedish Melanoma Study Group.DiscussionThis is the first randomized prospective trial on the potential benefit of imaging as a part of the follow-up scheme after radical surgery for high-risk CMM.ResultsThe first patient was recruited in June 2017 and as of April 2020, almost 500 patients had been included at 19 centers in Sweden.Trial registrationClinicalTrials.gov, NCT 03116412. Registered 17 April 2017, https://clinicaltrials.gov/ct2/show/study/NCT03116412
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- Wang, Kevin K., et al.
(författare)
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Blood-based traumatic brain injury biomarkers : Clinical utilities and regulatory pathways in the United States, Europe and Canad
- 2021
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Ingår i: Expert Review of Molecular Diagnostics. - : Expert Reviews Ltd.. - 1473-7159 .- 1744-8352. ; 21:12, s. 1303-1321
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Forskningsöversikt (refereegranskat)abstract
- Introduction: Traumatic brain injury (TBI) is a major global health issue, resulting in debilitating consequences to families, communities, and health-care systems. Prior research has found that biomarkers aid in the pathophysiological characterization and diagnosis of TBI. Significantly, the FDA has recently cleared both a bench-top assay and a rapid point-of-care assays of tandem biomarker (UCH-L1/GFAP)-based blood test to aid in the diagnosis mTBI patients. With the global necessity of TBI biomarkers research, several major consortium multicenter observational studies with biosample collection and biomarker analysis have been created in the USA, Europe, and Canada. As each geographical region regulates its data and findings, the International Initiative for Traumatic Brain Injury Research (InTBIR) was formed to facilitate data integration and dissemination across these consortia.Areas covered: This paper covers heavily investigated TBI biomarkers and emerging non-protein markers. Finally, we analyze the regulatory pathways for converting promising TBI biomarkers into approved in-vitro diagnostic tests in the United States, European Union, and Canada.Expert opinion: TBI biomarker research has significantly advanced in the last decade. The recent approval of an iSTAT point of care test to detect mild TBI has paved the way for future biomarker clearance and appropriate clinical use across the globe.
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- Kimonis, Eva R., et al.
(författare)
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Can a laboratory measure of emotional processing enhance the statistical prediction of aggression and delinquency in detained adolescents with callous-unemotional traits?
- 2007
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Ingår i: Journal of Abnormal Child Psychology. - : Springer Science and Business Media LLC. - 0091-0627 .- 1573-2835. ; 35:5, s. 773-785
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Tidskriftsartikel (refereegranskat)abstract
- In this cross-sectional study, we investigated whether the combination of the presence of callous-unemotional (CU) traits and emotional deficits to distressing stimuli, assessed by a computerized dot-probe task, enhanced the statistical prediction of aggression and delinquency in a sample of 88 detained and predominantly African-American (68%) adolescents (M age = 15.57; SD = 1.28). Overall, self-reported CU traits were associated with self-report measures of aggression and delinquency, but not with official records of arrests. However, there was an interaction between CU traits and emotional deficits for predicting self-reported aggression, self-reported violent delinquency, and a record of violent arrests. Youth high on CU traits and who showed a deficit in their responses to visual depictions of distress showed the highest levels of aggression and violent delinquency.
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- Muñoz, Luna C., et al.
(författare)
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The peer relationships of youths with psychopathic personality traits : A matter of perspective
- 2008
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Ingår i: Criminal justice and behavior. - London : Sage Publications. - 0093-8548 .- 1552-3594. ; 35:2, s. 212-227
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Tidskriftsartikel (refereegranskat)abstract
- Because a callous use of others in many short-term relationships is one criterion for diagnosing psychopathy in adults, one would expect adolescents who are high on psychopathic personality traits to have unstable, conflict-ridden peer relationships. Little is known about this, however, or about the peer activities of youths who are high in psychopathic traits. The authors examined relationship quality and delinquency with peers in a community sample of 12- to 15-year-old adolescents who were stably high or stably low on psychopathic traits during 4 years. Peers also provided data on relationship quality. Youths high on psychopathic traits often engaged in antisocial activities with their peers. Although they reported conflict in their peer relationships, their peers did not report low support or high conflict in those relationships. The authors conclude that youths with psychopathic traits have biased perspectives on interactions with close peers, and this might underlie future problems.
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- Munoz, Luna C., et al.
(författare)
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The reliability, stability, and predictive utility of the self-report version of the Antisocial Process Screening Device
- 2007
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 48:4, s. 299-312
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Tidskriftsartikel (refereegranskat)abstract
- The psychometric properties of the self-report version of the Antisocial Processes Screening Device (APSD; Frick & Hare, 2001), a rating scale developed to assess traits associated with the construct of psychopathy in youth, was tested in a sample of 91 non-referred young adolescents with an average age of 13.38 (SD = 1.75) at the initial assessment. The sample was recruited from a large community-wide screening, where youth with conduct problems and youth high on psychopathic traits were over-sampled. The sample was reassessed three times at yearly intervals. The self-report scores on the APSD showed moderate correlations with parent ratings of psychopathic traits, were moderately stable across 1-2 years, and showed significant correlations with measures of antisocial behavior both concurrently and predictively One major weakness of the self-report ratings was the low internal consistency of the subscales, which were much lower than the internal consistency found on the parent report version of the scale.
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- Muñoz, Luna C., et al.
(författare)
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Types of aggression, responsiveness to provocation, and callous-unemotional traits in detained adolescents
- 2008
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Ingår i: Journal of Abnormal Child Psychology. - : Springer Science and Business Media LLC. - 0091-0627 .- 1573-2835. ; 36:1, s. 15-28
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigated differences in the behavioral and psychophysiological responses to provocation and in the level of callous-unemotional traits in boys exhibiting different patterns of aggression. Eighty-five boys (ages 13-18) in a juvenile detention center played a competitive computer task against a hypothetical peer who provided low and high levels of provocation. Youth high on both self-reported reactive and proactive aggression showed different behavioral responses to provocation than youth high on only reactive aggression. Specifically, the combined group showed high levels of aggressive responses without any provocation, whereas the group high on reactive aggression showed an increase in aggressive responding to low provocation. Further, results revealed a trend for the combined group to show lower levels of skin conductance reactivity to low provocation if they were also high on callous-unemotional traits.
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- Munoz, Luna C., et al.
(författare)
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Verbal ability and delinquency : testing the moderating role of psychopathic traits
- 2008
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Ingår i: Journal of Child Psychology and Psychiatry. - : Wiley. - 0021-9630 .- 1469-7610. ; 49:4, s. 414-421
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Tidskriftsartikel (refereegranskat)abstract
- Background Impaired verbal abilities are one of the most consistent risk factors for serious antisocial and delinquent behavior. However, individuals with psychopathic traits often show serious antisocial behavior, despite showing no impairment in their verbal abilities. Thus, the aim of the current study was to examine whether psychopathy moderates the relationship between verbal abilities and delinquent behavior in a sample of detained youth. Methods The sample included 100 detained adolescent boys who were assessed on self-reported delinquent acts and psychopathic traits, as well as their age at first offense based on official records. Participants also completed a competitive computer task involving two levels of provocation, during which skin conductance was measured. A standard measure of receptive vocabulary was individually administered. Results As predicted, there was a significant interaction between callous-unemotional (CU) traits (a critical dimension of psychopathy) and verbal ability when predicting violent delinquency. Individuals who were high on CU traits with higher scores on the measure of verbal abilities reported the greatest violent delinquency. These individuals also showed the lowest level of skin conductance reactivity during the provocation task. Conclusions The results suggest CU traits are an important moderator of the relation between verbal abilities and violent delinquency.
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- Sebastián, David, et al.
(författare)
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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
- 2012
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:14, s. 5523-5528
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates in mitochondrial fusion and undergoes repression in muscle from obese or type 2 diabetic patients. Here, we provide in vivo evidence that Mfn2 plays an essential role in metabolic homeostasis. Liver-specific ablation of Mfn2 in mice led to numerous metabolic abnormalities, characterized by glucose intolerance and enhanced hepatic gluconeogenesis. Mfn2 deficiency impaired insulin signaling in liver and muscle. Furthermore, Mfn2 deficiency was associated with endoplasmic reticulum stress, enhanced hydrogen peroxide concentration, altered reactive oxygen species handling, and active JNK. Chemical chaperones or the antioxidant N-acetylcysteine ameliorated glucose tolerance and insulin signaling in liver-specific Mfn2 KO mice. This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo.
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