Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Munroe Patricia) > (2010-2014) > (2012) > Hingorani Aroon D > Large-Scale Gene-Ce...

1 of 1
Previous record
Next record
To hitlist

Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

Asselbergs, Folkert W. (author)

Guo, Yiran (author)

van Iperen, Erik P. A. (author)

Sivapalaratnam, Suthesh (author)

Tragante, Vinicius (author)

Lanktree, Matthew B. (author)

Lange, Leslie A. (author)

Almoguera, Berta (author)

Appelman, Yolande E. (author)

Barnard, John (author)

Baumert, Jens (author)

Beitelshees, Amber L. (author)

Bhangale, Tushar R. (author)

Chen, Yii-Der Ida (author)

Gaunt, Tom R. (author)

Gong, Yan (author)

Hopewell, Jemma C. (author)

Johnson, Toby (author)

Kleber, Marcus E. (author)

Langaee, Taimour Y. (author)

Li, Mingyao (author)

Li, Yun R. (author)

Liu, Kiang (author)

McDonough, Caitrin W. (author)

Meijs, Matthijs El. (author)

Middelberg, Rita P. S. (author)

Musunuru, Kiran (author)

Nelson, Christopher P. (author)

O'Connell, Jeffery R. (author)

Padmanabhan, Sandosh (author)

Pankow, James S. (author)

Pankratz, Nathan (author)

Rafelt, Suzanne (author)

Rajagopalan, Ramakrishnan (author)

Romaine, Simon P. R. (author)

Schork, Nicholas J. (author)

Shaffer, Jonathan (author)

Shen, Haiqing (author)

Smith, Erin N. (author)

Tischfield, Sam E. (author)

van der Most, Peter J. (author)

van Vliet-Ostaptchouk, Jana V. (author)

Verweij, Niek (author)

Volcik, Kelly A. (author)

Zhang, Li (author)

Bailey, Kent R. (author)

Bailey, Kristian M. (author)

Bauer, Florianne (author)

Boer, Jolanda M. A. (author)

Braund, Peter S. (author)

Burt, Amber (author)

Burton, Paul R. (author)

Buxbaum, Sarah G. (author)

Chen, Wei (author)

Cooper-DeHoff, Rhonda M. (author)

Cupples, L. Adrienne (author)

deJong, Jonas S. (author)

Delles, Christian (author)

Duggan, David (author)

Fornage, Myriam (author)

Furlong, Clement E. (author)

Glazer, Nicole (author)

Gums, John G. (author)

Hastie, Claire (author)

Holmes, Michael V. (author)

Illig, Thomas (author)

Kirkland, Susan A. (author)

Kivimaki, Mika (author)

Klein, Ronald (author)

Klein, Barbara E. (author)

Kooperberg, Charles (author)

Kottke-Marchant, Kandice (author)

Kumari, Meena (author)

LaCroix, Andrea Z. (author)

Mallela, Laya (author)

Murugesan, Gurunathan (author)

Ordovas, Jose (author)

Ouwehand, Willem H. (author)

Post, Wendy S. (author)

Saxena, Richa (author)

Scharnagl, Hubert (author)

Schreiner, Pamela J. (author)

Shah, Tina (author)

Shields, Denis C. (author)

Shimbo, Daichi (author)

Srinivasan, Sathanur R. (author)

Stolk, Ronald P. (author)

Swerdlow, Daniel I. (author)

Taylor Jr, Herman A. (author)

Topo, Eric J. (author)

Toskala, Elina (author)

van Pelt, Joost L. (author)

van Setten, Jessica (author)

Yusuf, Salim (author)

Whittaker, John C. (author)

Zwinderman, A. H. (author)

Anand, Sonia S. (author)

Balmforth, Anthony J. (author)

Berenson, Gerald S. (author)

Bezzina, Connie R. (author)

Boehm, Bernhard O. (author)

Boerwinkle, Eric (author)

Casas, Juan P. (author)

Caulfield, Mark J. (author)

Clarke, Robert (author)

Connell, John M. (author)

Cruickshanks, Karen J. (author)

Davidson, Karina W. (author)

Day, Ian N. M. (author)

de Bakker, Paul I. W. (author)

Doevendans, Pieter A. (author)

Dominiczak, Anna E. (author)

Hall, Alistair S. (author)

Hartman, Catharina A. (author)

Hengstenberg, Christian (author)

Hillege, Hans L. (author)

Hofker, Marten H. (author)

Humphries, Steve E. (author)

Jarvik, Gail P. (author)

Johnson, Julie A. (author)

Kaess, Bernhard M. (author)

Kathiresan, Sekar (author)

Koenig, Wolfgang (author)

Lawlor, Debbie A. (author)

Maerz, Winfried (author)

Melander, Olle (author): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups

Mitchell, Braxton D. (author)

Montgomery, Grant W. (author)

Munroe, Patricia B. (author)

Murray, Sarah S. (author)

Newhouse, Stephen J. (author)

Onland-Moret, N. Charlotte (author)

Poulter, Neil (author)

Psaty, Bruce (author)

Redline, Susan (author)

Rich, Stephen S. (author)

Rotter, Jerome I. (author)

Schunkert, Heribert (author)

Sever, Peter (author)

Shuldiner, Alan R. (author)

Silverstein, Roy L. (author)

Stanton, Alice (author)

Thorand, Barbara (author)

Trip, Mieke D. (author)

Tsai, Michael Y. (author)

van der Harst, Pim (author)

van der Schoot, Ellen (author)

van der Schouw, Yvonne T. (author)

Verschuren, W. M. Monique (author)

Watkins, Hugh (author)

Wilde, Arthur A. M. (author)

Wolffenbuttel, Bruce H. R. (author)

Whitfield, John B. (author)

Hovingh, G. Kees (author)

Ballantyne, Christie M. (author)

Wijmenga, Cisca (author)

Reilly, Muredach P. (author)

Martin, Nicholas G. (author)

Wilson, James G. (author)

Rader, Daniel J. (author)

Samani, Nilesh J. (author)

Reiner, Alex P. (author)

Hegele, Robert A. (author)

Kastelein, John J. P. (author)

Hingorani, Aroon D. (author)

Talmud, Philippa J. (author)

Hakonarson, Hakon (author)

Elbers, Clara C. (author)

Keating, Brendan J. (author)

Drenos, Fotios (author)

show less...

(creator_code:org_t)

Elsevier BV, 2012
2012
English.
In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 91:5, s. 823-838

Related links:: http://dx.doi.org/10...; show more...; https://doi.org/10.1...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.

Find in a library

American Journal of Human Genetics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Asselbergs, Folk ...; Guo, Yiran; van Iperen, Erik ...; Sivapalaratnam, ...; Tragante, Vinici ...; Lanktree, Matthe ...; show more...; Lange, Leslie A.; Almoguera, Berta; Appelman, Yoland ...; Barnard, John; Baumert, Jens; Beitelshees, Amb ...; Bhangale, Tushar ...; Chen, Yii-Der Id ...; Gaunt, Tom R.; Gong, Yan; Hopewell, Jemma ...; Johnson, Toby; Kleber, Marcus E ...; Langaee, Taimour ...; Li, Mingyao; Li, Yun R.; Liu, Kiang; McDonough, Caitr ...; Meijs, Matthijs ...; Middelberg, Rita ...; Musunuru, Kiran; Nelson, Christop ...; O'Connell, Jeffe ...; Padmanabhan, San ...; Pankow, James S.; Pankratz, Nathan; Rafelt, Suzanne; Rajagopalan, Ram ...; Romaine, Simon P ...; Schork, Nicholas ...; Shaffer, Jonatha ...; Shen, Haiqing; Smith, Erin N.; Tischfield, Sam ...; van der Most, Pe ...; van Vliet-Ostapt ...; Verweij, Niek; Volcik, Kelly A.; Zhang, Li; Bailey, Kent R.; Bailey, Kristian ...; Bauer, Florianne; Boer, Jolanda M. ...; Braund, Peter S.; Burt, Amber; Burton, Paul R.; Buxbaum, Sarah G ...; Chen, Wei; Cooper-DeHoff, R ...; Cupples, L. Adri ...; deJong, Jonas S.; Delles, Christia ...; Duggan, David; Fornage, Myriam; Furlong, Clement ...; Glazer, Nicole; Gums, John G.; Hastie, Claire; Holmes, Michael ...; Illig, Thomas; Kirkland, Susan ...; Kivimaki, Mika; Klein, Ronald; Klein, Barbara E ...; Kooperberg, Char ...; Kottke-Marchant, ...; Kumari, Meena; LaCroix, Andrea ...; Mallela, Laya; Murugesan, Gurun ...; Ordovas, Jose; Ouwehand, Willem ...; Post, Wendy S.; Saxena, Richa; Scharnagl, Huber ...; Schreiner, Pamel ...; Shah, Tina; Shields, Denis C ...; Shimbo, Daichi; Srinivasan, Sath ...; Stolk, Ronald P.; Swerdlow, Daniel ...; Taylor Jr, Herma ...; Topo, Eric J.; Toskala, Elina; van Pelt, Joost ...; van Setten, Jess ...; Yusuf, Salim; Whittaker, John ...; Zwinderman, A. H ...; Anand, Sonia S.; Balmforth, Antho ...; Berenson, Gerald ...; Bezzina, Connie ...; Boehm, Bernhard ...; Boerwinkle, Eric; Casas, Juan P.; Caulfield, Mark ...; Clarke, Robert; Connell, John M.; Cruickshanks, Ka ...; Davidson, Karina ...; Day, Ian N. M.; de Bakker, Paul ...; Doevendans, Piet ...; Dominiczak, Anna ...; Hall, Alistair S ...; Hartman, Cathari ...; Hengstenberg, Ch ...; Hillege, Hans L.; Hofker, Marten H ...; Humphries, Steve ...; Jarvik, Gail P.; Johnson, Julie A ...; Kaess, Bernhard ...; Kathiresan, Seka ...; Koenig, Wolfgang; Lawlor, Debbie A ...; Maerz, Winfried; Melander, Olle; Mitchell, Braxto ...; Montgomery, Gran ...; Munroe, Patricia ...; Murray, Sarah S.; Newhouse, Stephe ...; Onland-Moret, N. ...; Poulter, Neil; Psaty, Bruce; Redline, Susan; Rich, Stephen S.; Rotter, Jerome I ...; Schunkert, Herib ...; Sever, Peter; Shuldiner, Alan ...; Silverstein, Roy ...; Stanton, Alice; Thorand, Barbara; Trip, Mieke D.; Tsai, Michael Y.; van der Harst, P ...; van der Schoot, ...; van der Schouw, ...; Verschuren, W. M ...; Watkins, Hugh; Wilde, Arthur A. ...; Wolffenbuttel, B ...; Whitfield, John ...; Hovingh, G. Kees; Ballantyne, Chri ...; Wijmenga, Cisca; Reilly, Muredach ...; Martin, Nicholas ...; Wilson, James G.; Rader, Daniel J.; Samani, Nilesh J ...; Reiner, Alex P.; Hegele, Robert A ...; Kastelein, John ...; Hingorani, Aroon ...; Talmud, Philippa ...; Hakonarson, Hako ...; Elbers, Clara C.; Keating, Brendan ...; Drenos, Fotios; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: American Journal ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

Subject headings

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub