↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Munyaneza E) "

Search: WFRF:(Munyaneza E)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Simoes, JFF, et al. (author) Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study 2021 In: Anaesthesia. - : Wiley. - 1365-2044 .- 0003-2409. ; 76:11, s. 1454-1464 Journal article (peer-reviewed)
2.	Panayidou, K, et al. (author) Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation 2018 In: Journal of the International AIDS Society. - : Wiley. - 1758-2652. ; 21:11, s. e25200- Journal article (peer-reviewed)
3.	Uwimana, A., et al. (author) Emergence and clonal expansion of in vitro artemisinin-resistantPlasmodium falciparum kelch13R561H mutant parasites in Rwanda 2020 In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 26, s. 1602-1608 Journal article (peer-reviewed)abstract Artemisinin resistance (delayedP. falciparumclearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa(1-4). Here we genotyped theP. falciparum K13(Pfkelch13) propeller domain, mutations in which can mediate artemisinin resistance(5,6), in pretreatment samples collected from recent dihydroarteminisin-piperaquine and artemether-lumefantrine efficacy trials in Rwanda(7). While cure rates were >95% in both treatment arms, thePfkelch13R561H mutation was identified in 19 of 257 (7.4%) patients at Masaka. Phylogenetic analysis revealed the expansion of an indigenous R561H lineage. Gene editing confirmed that this mutation can drive artemisinin resistance in vitro. This study provides evidence for the de novo emergence ofPfkelch13-mediated artemisinin resistance in Rwanda, potentially compromising the continued success of antimalarial chemotherapy in Africa. Identification in Rwanda of mutations inPlasmodium falciparumcapable of conferring in vitro resistance to artemisinin, an essential medicine for the treatment of malaria, underscore the crucial need for surveillance in Africa to safeguard efficacy of life-saving therapies.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Bernard, C. (1); Losada, M. (1); Williams, E. (1); Ahmad, A. (1); Gupta, A. (1); Wright, D. (1); show more...; Hodgson, R. (1); Shaw, C. (1); Martin, J. (1); Chew, MH (1); Espin-Basany, E (1); Lakkis, Z (1); Sharma, S. (1); Campbell, M. (1); Das, A. (1); Kumar, A. (1); Gupta, R. (1); Ahmad, S. (1); Tan, L. (1); Sonnerborg, A (1); Nowak, K. (1); Baker, M. (1); O'Brien, S. (1); Ripolles-Melchor, J. (1); Wood, R (1); Agarwal, G (1); Basu, S (1); Negoi, I (1); Tripathi, M (1); Desai, A. (1); Evans, J. (1); Sharma, A (1); Xu, W (1); Shah, R. (1); Rodriguez, J. (1); Duran, I (1); Stephan, C (1); Jimenez, R. (1); King, J. (1); Kjaer, J (1); Barker, J (1); Di Martino, M. (1); Phillips, A. (1); Menard, D (1); Hamouda, O (1); Paredes, R (1); Fleming, C (1); Stadler, J (1); Tariq, M. (1); Wong, E. (1); show less...

University: Karolinska Institutet (2); University of Gothenburg (1); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view