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- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
- Jolliffe, DA, et al.
(författare)
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Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials
- 2020
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundA 2017 meta-analysis of data from 25 randomised controlled trials of vitamin D supplementation for the prevention of acute respiratory infections revealed a protective effect of the intervention. Since then, 20 new RCTs have been completed.MethodsSystematic review and meta-analysis of data from randomised controlled trials (RCTs) of vitamin D for ARI prevention using a random effects model. Pre-specified sub-group analyses were done to determine whether effects of vitamin D on risk of ARI varied according to baseline 25-hydroxyvitamin D (25[OH]D) concentration or dosing regimen. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and the ClinicalTrials.gov registry from inception to 1st May 2020. Double-blind RCTs of supplementation with vitamin D or calcidiol, of any duration, were eligible if they were approved by a Research Ethics Committee and if ARI incidence was collected prospectively and pre-specified as an efficacy outcome. Aggregate data, stratified by baseline 25(OH)D concentration, were obtained from study authors. The study was registered with PROSPERO (no. CRD42020190633).FindingsWe identified 45 eligible RCTs (total 73,384 participants). Data were obtained for 46,331 (98.0%) of 47,262 participants in 42 studies, aged 0 to 95 years. For the primary comparison of vitamin D supplementation vs. placebo, the intervention reduced risk of ARI overall (Odds Ratio [OR] 0.91, 95% CI 0.84 to 0.99; P for heterogeneity 0.01). No statistically significant effect of vitamin D was seen for any of the sub-groups defined by baseline 25(OH)D concentration. However, protective effects were seen for trials in which vitamin D was given using a daily dosing regimen (OR 0.75, 95% CI 0.61 to 0.93); at daily dose equivalents of 400-1000 IU (OR 0.70, 95% CI 0.55 to 0.89); and for a duration of ≤12 months (OR 0.82, 95% CI 0.72 to 0.93). No significant interaction was seen between allocation to vitamin D vs. placebo and dose frequency, dose size, or study duration. Vitamin D did not influence the proportion of participants experiencing at least one serious adverse event (OR 0.97, 95% CI 0.86 to 1.09). Risk of bias within individual studies was assessed as being low for all but three trials. A funnel plot showed left-sided asymmetry (P=0.008, Egger’s test).InterpretationVitamin D supplementation was safe and reduced risk of ARI, despite evidence of significant heterogeneity across trials. Protection was associated with administration of daily doses of 400-1000 IU vitamin D for up to 12 months. The relevance of these findings to COVID-19 is not known and requires investigation.FundingNone
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| 8. |
- Moore, Alexander, et al.
(författare)
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Penetrometry in Microgravity- From Brie to Bennu
- 2022
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Ingår i: EPSC Abstracts Vol. 16, 2022. - : Copernicus GmbH.
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Konferensbidrag (refereegranskat)abstract
- In this abstract we discuss a proposal for a microgravity flight campaign within which we will investigate penetrometry in a microgravity environment. Understanding the mechanical properties of solar system minor bodies is essential for understanding their origin and evolution. Past missions such as Hayabusa-2 and OSIRIS-REX have landed on asteroids and taken samples to discover what these bodies are made of. However, there has been conflicting evidence and reports into the physical properties of the granular surface material of these bodies. With future missions such as JAXA’s MMX mission travelling to Phobos to take a sample of the body the results from this campaign will be very important to that and future missions. Penetrometry, i.e. the determination of the reaction force an object experiences as it penetrates into a surface, can help to understand the essential properties regarding regolith such as grain size, grain shape, cohesion and bulk density. The usage of penetrometry however has mostly been limited ground-based studies such as soil sciences or even cheese maturation. Very little is known about the underlying physics of penetrometry. Results of penetrometry experiments are largely analysed based on empirical models, which presents us with a challenge if we want to apply the same parameters to understand granular materials on asteroid surfaces. Obviously, gravity cannot be eliminated in the laboratory. Hence, it is essential to verify penetrometry as a method and validate penetrometry instrument designs in microgravity.For this purpose, we propose a parabolic flight campaign. Our experiment will test the use of penetrometry in asteroid-analogue environments by investigating samples with varying properties such as grain size and shape. The microgravity aspect of the experiment is one of the most important factors because it enables us to correlate laboratory experiments at 1g with identical setups in a gravity regime relevant to asteroids. The proposed experimental setup will include a variety of samples with varying grain sizes, grain shapes, porosities and grain size distributions. The penetrometer used will also have varying properties such as the diameter, shape, and velocity of penetration. A robotic arm will push a penetrometer into the samples to measure the reaction force which can then be used to determine the mechanical properties of the samples. By varying the samples and penetrometer properties it will be possible to better understand the relevant parameters affecting reaction force. The suitability of the setup will also be reviewed to understand its usage and applicability in microgravity environments such as the robotic arm that will be used. All of the experiments carried out during the parabolic campaign will also be done at 1g to compare the tests in varying gravity levels. With a better understanding of the science behind penetrometry and the effects of microgravity, future missions will be better prepared and be able to use penetrometry more effectively to understand small-body surfaces.
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