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Obesity is accompan...
Obesity is accompanied by disturbances in peripheral glucocorticoid metabolism and changes in FA recycling.
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- Simonyte, Kotryna, 1979- (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden
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- Rask, Eva, 1958- (författare)
- Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Näslund, Ingmar (författare)
- Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Angelhed, Jan-Erik, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg,Department of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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- Lönn, Lars, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,University of Gothenburg,Department of Radiology and Vascular Surgery, Faculty of Health Sciences, Rigshospital, Copenhagen, Denmark
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden
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- Mattsson, Cecilia (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden
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(creator_code:org_t)
- 2012-09-10
- 2009
- Engelska.
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Ingår i: Obesity (Silver Spring, Md.). - : Wiley. - 1930-7381 .- 1930-739X. ; 17:11, s. 1982-7
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- The glucocorticoid activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is of major interest in obesity-related morbidity. Alterations in tissue-specific cortisol levels may influence lipogenetic and gluco/glyceroneogenetic pathways in fat and liver. We analyzed the expression and activity of 11betaHSD1 as well as the expression of phosphoenolpyruvate carboxykinase (PEPCK), sterol regulatory element binding protein (SREBP), and fatty acid synthase (FAS) in adipose and liver and investigated putative associations between 11betaHSD1 and energy metabolism genes. A total of 33 obese women (mean BMI 44.6) undergoing gastric bypass surgery were enrolled. Subcutaneous adipose tissue (SAT), omental fat (omental adipose tissue (OmAT)), and liver biopsies were collected during the surgery. 11betaHSD1 gene expression was higher in SAT vs. OmAT (P = 0.013), whereas the activity was higher in OmAT (P = 0.009). The SAT 11betaHSD1 correlated with waist circumference (P = 0.045) and was an independent predictor for the OmAT area in a linear regression model. Energy metabolism genes had AT depot-specific expression; higher leptin and SREBP in SAT than OmAT, but higher PEPCK in OmAT than SAT. The expression of 11betaHSD1 correlated with PEPCK in both AT depots (P = 0.05 for SAT and P = 0.0001 for OmAT). Hepatic 11betaHSD1 activity correlated negatively with abdominal adipose area (P = 0.002) and expression positively with PEPCK (P = 0.003). In human obesity, glucocorticoid regeneration in the SAT is associated with central fat accumulation indicating that the importance of this specific fat depot is underestimated. Central fat accumulation is negatively associated with hepatic 11betaHSD1 activity. A disturbance in peripheral glucocorticoid metabolism is associated with changes in genes involved in fatty acid (FA) recycling in adipose tissue (AT).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- genetics
- metabolism
- Adiposity
- Adult
- Fatty Acid Synthetase Complex
- genetics
- metabolism
- Fatty Acids
- metabolism
- Female
- Glucocorticoids
- metabolism
- Humans
- Intra-Abdominal Fat
- enzymology
- Leptin
- genetics
- metabolism
- Liver
- enzymology
- Middle Aged
- Obesity
- metabolism
- Phosphoenolpyruvate Carboxykinase (ATP)
- genetics
- metabolism
- RNA
- Messenger
- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Sterol Regulatory Element Binding Proteins
- genetics
- metabolism
- Subcutaneous Fat
- Abdominal
- enzymology
- Waist Circumference
- Messenger
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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