SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Nabulsi Nabeel)
 

Search: WFRF:(Nabulsi Nabeel) > Lindgren Noora > Effects of age, BMI...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Effects of age, BMI and sex on the glial cell marker TSPO : a multicentre [11C]PBR28 HRRT PET study

Tuisku, Jouni (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland.
Plaven-Sigray, Pontus (author)
Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.
Gaiser, Edward C. (author)
Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.
show more...
Airas, Laura (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Al-Abdulrasul, Haidar (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Bruck, Anna (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Carson, Richard E. (author)
Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.
Chen, Ming-Kai (author)
Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.
Cosgrove, Kelly P. (author)
Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.
Ekblad, Laura (author)
Univ Turku, Turku PET Ctr, Turku, Finland.
Esterlis, Irina (author)
Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.
Farde, Lars (author)
Karolinska Institutet
Forsberg, Anton (author)
Karolinska Institutet
Halldin, Christer (author)
Karolinska Institutet
Helin, Semi (author)
Univ Turku, Turku PET Ctr, Turku, Finland.
Kosek, Eva (author)
Karolinska Institutet
Lekander, Mats (author)
Stockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neuroscience, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden.
Lindgren, Noora (author)
Univ Turku, Turku PET Ctr, Turku, Finland.
Marjamaki, Paivi (author)
Univ Turku, Turku PET Ctr, Turku, Finland.
Rissanen, Eero (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Sucksdorff, Marcus (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Varrone, Andrea (author)
Stockholms universitet,Stressforskningsinstitutet,Psykologiska institutionen,Karolinska Institutet, Sweden; Stockholm County, Sweden,Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Univ, Dept Psychol, Stress Res Inst, Stockholm, Sweden.
Collste, Karin (author)
Gallezot, Jean-Dominique (author)
Hillmer, Ansel (author)
Huang, Yiyun (author)
Hoglund, Caroline O. (author)
Johansson, Jarkko (author)
Karolinska Institutet
Jucaite, Aurelija (author)
Karolinska Institutet
Lampa, Jon (author)
Nabulsi, Nabeel (author)
Pittman, Brian (author)
Sandiego, Christine M. (author)
Stenkrona, Per (author)
Karolinska Institutet
Rinne, Juha (author)
Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.
Matuskey, David (author)
Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA.;Yale Univ, Dept Psychiat, New Haven, CT 06511 USA.
Cervenka, Simon (author)
Karolinska Institutet
show less...
Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Turku PET Ctr, POB 52, Turku 20521, Finland. Karolinska Inst & Stockholm Cty, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (creator_code:org_t)
2019-07-30
2019
English.
In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer. - 1619-7070 .- 1619-7089. ; 46:11, s. 2329-2338
Related links:
https://doi.org/10.1...
show more...
https://uu.diva-port... (primary) (Raw object)
https://link.springe...
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
http://kipublication...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [C-11]PBR28. Methods [C-11]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19-80 years; BMI range 17.6-36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (V-T) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts. Results There were significant positive correlations between age and V-T in the frontal and temporal cortex. BMI showed a significant negative correlation with V-T in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher V-T. A subgroup analysis revealed a positive correlation between V-T and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects. Conclusion These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

PET
TSPO
[C-11]PBR28
Ageing
Sex difference
BMI

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view