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Why Is Amyloid-β PE...
Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?
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- Reimand, Juhan (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Tallinn University of Technology
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- Groot, Colin (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Teunissen, Charlotte E. (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Windhorst, Albert D. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Boellaard, Ronald (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Barkhof, Frederik (author)
- University College London,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Nazarenko, Sergei (author)
- Tallinn University of Technology
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- van der Flier, Wiesje M. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- van Berckel, Bart N.M. (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Bouwman, Femke (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2020
- 2020
- English 11 s.
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In: Journal of Alzheimer's disease : JAD. - 1387-2877. ; 73:2, s. 559-569
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
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- BACKGROUND: Amyloid-β positron emission tomography (PET) and cerebrospinal fluid (CSF) Aβ42 are considered interchangeable for clinical diagnosis of Alzheimer's disease. OBJECTIVE: To explore the clinical reasoning for requesting additional amyloid-β PET after performing CSF biomarkers. METHODS: We retrospectively identified 72 memory clinic patients who underwent amyloid-β PET after CSF biomarkers analysis for clinical diagnostic evaluation between 2011 and 2019. We performed patient chart reviews to identify factors which led to additional amyloid-β PET. Additionally, we assessed accordance with appropriate-use-criteria (AUC) for amyloid-β PET. RESULTS: Mean patient age was 62.0 (SD = 8.1) and mean Mini-Mental State Exam score was 23.6 (SD = 3.8). CSF analysis conflicting with the clinical diagnosis was the most frequent reason for requesting an amyloid-β PET scan (n = 53, 74%), followed by incongruent MRI (n = 16, 22%), unusual clinical presentation (n = 11, 15%) and young age (n = 8, 11%). An amyloid-β PET scan was rarely (n = 5, 7%) requested in patients with a CSF Aβ+/tau+ status. Fifteen (47%) patients with a post-PET diagnosis of AD had a predominantly non-amnestic presentation. In n = 11 (15%) cases, the reason that the clinician requested amyloid-β was not covered by AUC. This happened most often (n = 7) when previous CSF analysis did not support current clinical diagnosis, which led to requesting amyloid-β PET. CONCLUSION: In this single-center study, the main reason for requesting an amyloid-β PET scan after performing CSF biomarkers was the occurrence of a mismatch between the primary clinical diagnosis and CSF Aβ/tau results.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer’s disease
- amyloid
- cerebrospinal fluid
- positron emission tomography
- tau proteins
Publication and Content Type
- art (subject category)
- ref (subject category)
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Reimand, Juhan
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Groot, Colin
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Teunissen, Charl ...
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Windhorst, Alber ...
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Boellaard, Ronal ...
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Barkhof, Frederi ...
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Nazarenko, Serge ...
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van der Flier, W ...
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van Berckel, Bar ...
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Scheltens, Phili ...
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Ossenkoppele, Ri ...
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Bouwman, Femke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Lund University