| 1. |
- Falconer, D., et al.
(författare)
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New Air-interface Technologies and Deployment Concepts
- 2006
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Ingår i: Technologies for the Wireless Future: Wireless World Research Forum (WWRF). - Chichester, UK : John Wiley & Sons. - 0470029056 - 9780470029053 ; , s. 131-226
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Barker, Dean, 1977, et al.
(författare)
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Pedagogical narrative: Working with technology as student teachers
- 2016
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Ingår i: Pedagogical Cases: Digital Technologies in Youth Physical Activity, Physical Education & Sport. - London : Routledge.
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Bokkapitel (refereegranskat)abstract
- The objective of this chapter is to provide an illustration of how digital technologies are being experienced/utilised/problematised by physical educators. This chapter introduces two Physical Education Teacher Education (PETE) students working at the University of Gothenburg and focuses on course work conducted by those students within their program. The students received an assignment to choose a particular digital technology, develop their own competence with that technology, and then demonstrate to peers how the technology can be used to facilitate learning related to the Swedish physical education curriculum for upper secondary school. A narrative of their experiences and reflections, developed through written reflections as well as informal conversations with the lead author, is presented in the first section. Three theoretical accounts of the practitioners’ narrative are then put forward. A Deweyan perspective draws attention to the ways that students and their situations are continually transformed in transaction and how digital technologies become implicated in this process. A Foucaultian perspective focuses on the regulating and controlling aspects of technology and highlights the need for care when using digital technologies. An applied Information Technology perspective highlights the ways in which digital technologies may become part of the social practices of physical education. After introducing these perspectives, a broader pedagogical account is offered in which connections between the three perspectives and current physical education scholarship is made. These connections concern: (1) meaning making; (2) student agency and possibilities for student decision making; (3) the effects of technology on lesson content; and (4) students’ digital competence. The chapter is concluded with reflections from the two PETE students.
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| 4. |
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| 5. |
- Huber, Vincent J., et al.
(författare)
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Aquaporins : Chemical inhibition by small molecules
- 2016
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Ingår i: Aquaporins in Health and Disease : New Molecular Targets for Drug Discovery - New Molecular Targets for Drug Discovery. - 9781498707831 - 9781498707848 ; , s. 249-271
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Bokkapitel (refereegranskat)abstract
- The human genome encodes 13 aquaporin isoforms with characteristic substrate specificity that are expressed at specific locations throughout the body. Of these isoforms, AQPs 1-4 serve important functions in renal water reabsorption. Consequently, specific AQP inhibitors have been proposed as 'aquaretics', a new class of drugs suitable to induce diuresis without concomitant salt wasting. Furthermore, animal experiments suggested that AQP4 inhibitors could be useful to treat some forms of brain edema. Other proposed applications for AQP inhibitors involve amongst others treatment of diabetes, inflammatory skin diseases and cancer. However, few of these putative applications have been critically evaluated against current forms of therapy. Furthermore, development of AQP inhibitors remains difficult and despite numerous efforts during at least the last 15 years very few AQP inhibitors have been described. Moreover, none of the hitherto described substances have been developed to a level where meaningful verification of proposed AQP drug targets in preclinical or clinical settings was possible. Nonetheless, encouraging progress towards development of such substances has been made during recent years. Novel cell-based assays facilitate high throughput screening of chemical compound libraries for hit discovery. AQP 3D structures have been solved for 10 isoforms, which can support rapidly evolving computational hit discovery methods, as well as hit to lead programs. In this chapter, we will provide a critical review of current evidence supporting relevance of AQPs as drug targets, describe current methods for AQP inhibitor discovery and will try to highlight challenges that remain before successful AQP inhibitor development.
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| 6. |
- Maury, J., et al.
(författare)
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Metabolic engineering of isoprenoid production: Reconstruction of multistep heterologous pathways in tractable hosts
- 2013
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Ingår i: Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches. - New York, NY : Springer New York. - 9781461440635 ; , s. 73-89
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Isoprenoids represent a wide group of chemically active compounds that can find a wide range of applications as flavors, perfumes, vitamins, nutraceuticals, and pharmaceuticals. Many isoprenoids are naturally produced in very low quantities by plants, which make their use in broader perspectives difficult. Microbial production of plant-originating isoprenoids quickly appeared as an alternative of choice. Metabolic engineering methods were applied and proved successful to improve the supply of precursors to derive toward isoprenoid compounds of interest. Combinations between metabolic engineering and the flourishing field of synthetic biology have also been observed with researchers attempting to reconstruct and optimize complex biosynthetic pathways in well-characterized and tractable microbial hosts. In this chapter, we review recent metabolic engineering studies for isoprenoid production in yeast and try to show, through key examples, that the fields of synthetic biology and metabolic engineering can go hand in hand to establish microbial cell factories for isoprenoid production.
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| 9. |
- Rivollier, Aymeric, et al.
(författare)
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Physiological Role of TNF in Mucosal Immunology : Regulation of Macrophage/Dendritic Cell Function
- 2015
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Ingår i: Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. - : S. Karger AG. - 0302-0665. - 9783318054743 ; 34, s. 9-26, s. 9-26
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Bokkapitel (refereegranskat)abstract
- Intestinal mononuclear phagocytes, comprising macrophages (Mφs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor-α (TNF) in regulating multiple aspects of intestinal Mφ and DC physiology, including their differentiation, migration, maturation, survival and effector functions. In inflammatory bowel disease, TNF signaling has been implicated in reprogramming monocyte differentiation from the anti-inflammatory Mφ lineage towards the pro-inflammatory mononuclear phagocyte lineage. These cells become a major source of TNF and, thus, may contribute to the chronic inflammatory process. Finally, we highlight some of the important gaps in our current knowledge regarding the role of TNF in Mφ and DC physiology and suggest important directions for future research in this field.
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