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Search: WFRF:(Niklasson B) > (2000-2004) > Lernmark Åke

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1.	Niklasson, B, et al. (author) Development of type 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus 2003 In: International journal of experimental diabetes research. ; 4, s. 35-44 Journal article (peer-reviewed)
2.	Niklasson, Bo, et al. (author) Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus. 2003 In: International journal of experimental diabesity research. - : Hindawi Limited. ; 4:1, s. 35-44 Journal article (peer-reviewed)abstract Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Lernmark, Åke (2)Undo refine; Lindberg, A Michael (2); Johansson, Susanne (2); Persson, Bengt (1); Daniels, Terri (1); Persson, B (1); show more...; Niklasson, Bo (1); Ortqvist, Eva (1); Hampe, C. S. (1); Bekris, Lynn (1); Niklasson, B (1); Daniels, T. (1); Hampe, Christiane S. (1); Bekris, L (1); Örtqvist, E. (1); Schaefer, Jonathan B (1); Heller, K E (1); Schønecker, B (1); Bildsøe, M (1); Widlund, P (1); Simonson, W T (1); Schaefer, J B (1); Rutledge, E (1); Heller, Knud E (1); Schønecker, Bryan (1); Bildsøe, Mogens (1); Widlund, Per (1); Simonson, William T (1); Rutledge, Elizabeth (1); show less...

University: Lund University (1); Linnaeus University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2003 (2)

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