| 1. |
- Bock, O., et al.
(författare)
-
Use of GNSS Tropospheric Products for Climate Monitoring (Working Group 3)
- 2020
-
Ingår i: Advanced GNSS Tropospheric Products for Monitoring Severe Weather Events and Climate. - Cham : Springer International Publishing. - 9783030139001 ; , s. 267-402
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- There has been growing interest in recent years in the use of homogeneously reprocessed ground-based GNSS, VLBI, and DORIS measurements for climate applications. Existing datasets are reviewed and the sensitivity of tropospheric estimates to the processing details is discussed. The uncertainty in the derived IWV estimates and linear trends is around 1 kg m^2 RMS and ± 0.3 kg m^2 per decade, respectively. Standardized methods for ZTD outlier detection and IWV conversion are proposed. The homogeneity of final time series is limited however by changes in the stations equipment and environment. Various homogenization algorithms have been evaluated based on a synthetic benchmark dataset. The uncertainty of trends estimated from the homogenized times series is estimated to ±0.5 kg m^2 per decade. Reprocessed GNSS IWV data are analysed along with satellites data, reanalyses and global and regional climate model simulations. A selection of global and regional reprocessed GNSS datasets and ERA-interim reanalysis are made available through the GOP-TropDB tropospheric database and online service. A new tropo SINEX format, providing new features and simplifications, was developed and it is going to be adopted by all the IAG services.
|
|
| 2. |
- Alves, Gustavo R., et al.
(författare)
-
International Cooperation for Remote Laboratory Use
- 2018
-
Ingår i: Contributions to Higher Engineering Education. - Singapore : Springer. - 9789811089176 ; , s. 1-31
-
Bokkapitel (refereegranskat)abstract
- Experimenting is fundamental to the training process of all scientists and engineers. While experiments have been traditionally done inside laboratories, the emergence of Information and Communication Technologies added two alternatives accessible anytime, anywhere. These two alternatives are known as virtual and remote laboratories and are sometimes indistinguishably referred as online laboratories. Similarly to other instructional technologies, virtual and remote laboratories require some effort from teachers in integrating them into curricula, taking into consideration several factors that affect their adoption (i.e., cost) and their educational effectiveness (i.e., benefit). This chapter analyzes these two dimensions and sustains the case where only through international cooperation it is possible to serve the large number of teachers and students involved in engineering education. It presents an example in the area of electrical and electronics engineering, based on a remote laboratory named Virtual Instruments System in Reality, and it then describes how a number of European and Latin American institutions have been cooperating under the scope of an Erasmus+ project, for spreading its use in Brazil and Argentina.
|
|
| 3. |
- Bruni, G., et al.
(författare)
-
PMT saturation due to large dynamic range
- 2018
-
Ingår i: GSI-FAIR Scientific Report 2017. - 2625-8692 .- 2625-8692. ; :1, s. 161-161
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Ahlman, Håkan, 1947, et al.
(författare)
-
En "ny" tumörmarkör.
- 1996
-
Ingår i: Klinisk Kemi i Norden, 8.. - Göteborg. ; , s. 45-52
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 8. |
|
|
| 9. |
- Nilsson Ekdahl, Kristina, et al.
(författare)
-
Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: A new paradigm for prostatic cancer?
- 2006
-
Ingår i: Current Topics in Complement. - : Springer. - 9780387322315 - 9780387341347 ; , s. 107-119
-
Bokkapitel (refereegranskat)abstract
- Understanding the protective mechanisms utilized by metastatic prostate cancer cells in order to avoid attack by complement or other parts of the innate immune system and to affect tumor angiogenesis and metastasis will help us to identify suitable targets for pharmaceutical intervention. We have shown that at least two different complement-attenuating mechanisms are at work in close proximity to prostasomes: transfer of CD59, which inhibits complement at the level of MAC insertion, and phosphorylation of C3 so as to make it resistant to (physiological) activation and thereby regulate complement at the convertase level. In addition, we have shown that both fibrinogen and vitronectin, which play critical roles in cell adhesion, are targets for prostasome-mediated phosphorylation. Given the broad specificity of the various PKs, it is most likely that other relevant substrates such as proteins involved in angiogenesis or different matrix proteins may be found. Finally, we have demonstrated that expression and function of different proteins capable of mediating these effects (CD59 and PKs, particularly PKA) are highly upregulated on prostasomes derived from malignant cell lines as compared to seminal prostasomes, suggesting that the malignant cell-associated prostasomes have a higher potential to interact with neighboring cells.The fact that substantial differences are found in protein expression profiles between physiological and pathological prostasomes may be relevant in the search for suitable clinical markers to identify patients with primary prostate cancer who are at risk for developing metastases. In addition, possible targets for therapeutic intervention may include GPI-anchored proteins and specific PKs present at high concentrations in close proximity to metastases. If the overexpression of RCAs and PKs on metastatic prostate cancer cells can be controlled or counteracted, these modifications could possibly also be used to potientate other types of immunotherapy.
|
|
| 10. |
|
|
