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- Hensel, Michael U., 1965, et al.
(author)
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Current changes in conditions and contexts for architectural research and practice: A brief introduction
- 2019
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In: The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice. - New York : Routledge, 2019. : Routledge. ; , s. 1-13
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Book chapter (other academic/artistic)abstract
- The discipline of architecture is currently undergoing a significant change as professional practice and academia seem to be transforming one another specifically through succinct research undertakings. This book continues the discussion started in The Changing Shape of Practice – Integrating Research and Design in Architecture on architectural offices’ modes of research and lines of inquiry in architecture and how it reshapes practice. The book aims to contribute to the mapping and discussion on research in architectural practice and its transformational impact and gives input to the discussions on where the architectural profession is heading. In this second volume, various research initiatives and modes in architectural practices are portrayed. The book also includes contributions that broaden the scope and put the developments into larger contexts, and present an overview of developments from different regional perspectives and of various social aspects of architecture. It also relates the developments in practice to educational efforts and to initiatives where the more traditional role of architects is challenged. The contributions include chapters by Walter Unterrainer, Anthony Burke, Renée Cheng and Andrea J. Johnson, and Michael U. Hensel, and on the practices atelier d’architecture autogérée, Helen & Hard, MVRDV and The Why Factory, NADAAA & Nader Tehrani, Nordic – Office of Architecture, Schmidt Hammer Lassen, Skidmore, Owings & Merrill, Void, Sarah Wigglesworth Architects, and Älvstranden Utveckling.
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- Hensel, Michael U., 1965, et al.
(author)
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The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice
- 2019
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In: The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice. - London : Routledge. - 9781315284088
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Book (other academic/artistic)abstract
- The discipline of architecture if currently undergoing a significant change as professional practice and academia seem to be transforming one another specifically through succinct research undertakings. This book continues the discussion started in The Changing Shape of Practice – Integrating Research and Design in Architecture on architectural offices’ modes of research and lines of inquiry in architecture and how it reshapes practice. The book aims to contribute to the mapping and discussion on research in architectural practice and its transformational impact and gives input to the discussions on where the architectural profession is heading. In this second volume various research initiatives and modes in architectural practices are portrayed. The book also includes contributions that broadens the scope and puts the developments into larger contexts and presents an overview of developments from different regional perspectives and of various social aspects of architecture. It also relates the developments in practice to educational efforts and to initiatives where the more traditional role of architects is challenged. The contributions include chapters by Walter Unterrainer, Anthony Burke, Renée Cheng and Andrea J. Johnson, and Michael Hensel and on the practices atelier d’architecture autogérée, Helen & Hard, MVRDV and The Why Factory, NADAAA & Nader Tehrani, Nordic – Office of Architecture, Schmidt Hammer Lassen, Skidmore, Owings & Merrill, Void, Sarah Wigglesworth Architects, and Älvstranden Utveckling.
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- Hensel, Michael U., 1965, et al.
(author)
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The Changing Shape of Practice. Integrating Research and Design in Architecture
- 2016
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Book (other academic/artistic)abstract
- Architectural practices worldwide have to deal with increasingly complex design requirements. How do practices acquire the ability to do so? The Changing Shape of Practice provides a handbook of examples for practices that wish to integrate more research into their work and a reference book for students that seek to prepare themselves for the changing shape of practice in architecture. It addresses the increasing integration of research undertaken in architectural practices of different sizes ranging from small to very large practices from the UK, USA, Europe and Asia. The book is organized according to the size of the practices which is significant in that it addresses the different structures and resourcing requirements that are enabled by specific practice sizes, as this determines and constrains the type, scope and modes of research available to a given practice. The practices covered include: Woods Bagot, Perkins + Will, White, AECOM, UN Studio, Shop Architects, PLP Architecture, Kieran Timberlake, 3XN / GXN, ONL, AZPML, Thomas Herzog + Partners, Herreros Arquitectos, Spacescape, OCEAN Design Research Association By taking stock of the current shape of practice, the book provides essential information for professional architects who are integrating research into their practice.
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- Mårtensson, Ulrika, et al.
(author)
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Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
- 2009
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In: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 150:2, s. 687-98
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Journal article (peer-reviewed)abstract
- In vitro studies suggest that the G protein-coupled receptor (GPR) 30 is a functional estrogen receptor. However, the physiological role of GPR30 in vivo is unknown, and it remains to be determined whether GPR30 is an estrogen receptor also in vivo. To this end, we studied the effects of disrupting the GPR30 gene in female and male mice. Female GPR30((-/-)) mice had hyperglycemia and impaired glucose tolerance, reduced body growth, increased blood pressure, and reduced serum IGF-I levels. The reduced growth correlated with a proportional decrease in skeletal development. The elevated blood pressure was associated with an increased vascular resistance manifested as an increased media to lumen ratio of the resistance arteries. The hyperglycemia and impaired glucose tolerance in vivo were associated with decreased insulin expression and release in vivo and in vitro in isolated pancreatic islets. GPR30 is expressed in islets, and GPR30 deletion abolished estradiol-stimulated insulin release both in vivo in ovariectomized adult mice and in vitro in isolated islets. Our findings show that GPR30 is important for several metabolic functions in female mice, including estradiol-stimulated insulin release.
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- Rydja, Johanna, et al.
(author)
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Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial
- 2021
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In: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 18:1
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Journal article (peer-reviewed)abstract
- Background: Rehabilitation in iNPH is suggested to be an important factor to improve patients'functions but there are lack of clinical trials evaluating the effect of rehabilitation interventions after shunt surgery in iNPH. The objective of this study was to evaluate the effect of a physical exercise programme and goal attainment for patients with idiopathic normal pressure hydrocephalus (iNPH) after surgery compared to a control group. Methods: This was a dual centre randomised controlled trial with assessor blinding, intention-to-treat (ITT) and per protocol (PP) analysis. Individuals diagnosed with iNPH scheduled to undergo shunt surgery at the Linkoping University Hospital in Linkoping and Sahlgrenska University Hospital in Gothenburg, Sweden were consecutively eligible for inclusion. Inclusion was conducted between January 2016 and June 2018. The patients were randomised 1:1 using sequentially numbered sealed envelopes to receive either written exercise information (control group) or written information and an additional supervised high-intensity, functional exercise programme (HIFE) executed twice weekly over 12 weeks (exercise group). Preoperatively, the patients set individual goals. The primary outcome was change from baseline in the total iNPH scale score at the post-intervention follow-up. Secondary outcomes were goal attainment, and change in the separate scores of gait, balance, neuropsychology and continence and in the total score after 6 months. Results: In total, 127 participants were randomised to the exercise group (n = 62) and to the control group (n=65). In the ITT population (exercise group, n =50; control group, n=59), there were no between-group differences in the primary outcome, but the attrition rate in the exercise group was high. The exercise group improved more than the control group in the balance domain scores after 6 months. Post-intervention, the PP exercise population achieved their set goals to a greater extent than the controls. Conclusions: An additional effect of the 12-week HIFE-programme on the overall improvement according to the iNPH-scale after shunt surgery in iNPH was not shown. This could be due to high attrition rate. However, the longterm effect on balance and higher goal achievement indicate beneficial influences of supervised physical exercise.
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- Uhlén, Mathias, et al.
(author)
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A pathology atlas of the human cancer transcriptome
- 2017
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 357:6352, s. 660-
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Journal article (peer-reviewed)abstract
- Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
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- Al Weswasi, Enes, 1985-, et al.
(author)
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Does sentence length affect the risk for criminal recidivism? A quasi-experimental study of three policy reforms in Sweden
- 2023
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In: Journal of Experimental Criminology. - : Springer Science and Business Media LLC. - 1573-3750 .- 1572-8315. ; 19:4, s. 971-999
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Journal article (peer-reviewed)abstract
- Objectives This study examines the relationship between incarceration time and post-release recidivism among first-time incarcerated adult offenders.Methods A quasi-experimental design was adopted consisting of three policy reforms that were treated as separate natural experiments. While holding imposed sentence length constant, these policy reforms either decreased or increased the required share of a sentence inmates needed to be incarcerated before being eligible for parole. Data consisted of large-scale administrative records containing all convictions for the Swedish cohorts born in 1958 and later.Results Results indicate that neither increased nor decreased incarceration time had a statistically significant effect on post-release recidivism, irrespective of how recidivism was measured.Conclusions Findings reveal little evidence for incarceration time having a criminogenic or specific preventive effect on post-release recidivism.
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