| 1. |
- Svensson, Fredric G., et al.
(författare)
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Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials
- 2021
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Ingår i: Nanomaterials. - : MDPI. - 2079-4991. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- In order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in vitro human whole blood model. To our knowledge, this is the first study of the molecular interaction between hybrid nanotitania and blood proteins. Two of the hybrid materials prepared with 3 nm colloidal titania and 10 nm hydrothermally synthesized titania induced strong coagulation and platelet activation but negligible complement activation. Hence, they have great potential as a new dressing for promoting wound healing. Unlike the other two, the third hybrid material using molecular ammonium oxo-lactato titanate as a titania source inhibited platelet consumption, TAT generation, and complement activation, apparently via lowered pH at the surface interface. It is therefore suitable for applications where a passivating surface is desired, such as drug delivery systems and extracorporeal circuits. This opens the possibility for a tailored blood response through the surface functionalization of titania.
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| 2. |
- Nilsson, C. L., et al.
(författare)
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Chromosome 19 Annotations with Disease Speciation: A First Report from the Global Research Consortium
- 2013
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 12:1, s. 134-149
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Tidskriftsartikel (refereegranskat)abstract
- A first research development progress report of the Chromosome 19 Consortium with members from Sweden, Norway, Spain, United States, China and India, a part of the Chromosome-centric Human Proteome Project (C-HPP) global initiative, is presented (http://www.c-hpp.org). From the chromosome 19 peptide-targeted library constituting 6159 peptides, a pilot study was conducted using a subset with 125 isotope-labeled peptides. We applied an annotation strategy with triple quadrupole, ESI-Qtrap, and MALDI mass spectrometry platforms, comparing the quality of data within and in between these instrumental set-ups. LC–MS conditions were outlined by multiplex assay developments, followed by MRM assay developments. SRM was applied to biobank samples, quantifying kallikrein 3 (prostate specific antigen) in plasma from prostate cancer patients. The antibody production has been initiated for more than 1200 genes from the entire chromosome 19, and the progress developments are presented. We developed a dedicated transcript microarray to serve as the mRNA identifier by screening cancer cell lines. NAPPA protein arrays were built to align with the transcript data with the Chromosome 19 NAPPA chip, dedicated to 90 proteins, as the first development delivery. We have introduced an IT-infrastructure utilizing a LIMS system that serves as the key interface for the research teams to share and explore data generated within the project. The cross-site data repository will form the basis for sample processing, including biological samples as well as patient samples from national Biobanks.
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| 3. |
- Nilsson Ekdahl, Kristina, et al.
(författare)
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Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles
- 2018
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Ingår i: Nanomedicine. - : Elsevier. - 1549-9634 .- 1549-9642. ; 14:3, s. 735-744
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Tidskriftsartikel (refereegranskat)abstract
- Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The α-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikreinactivation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease.
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| 4. |
- Ericsson, Karin, et al.
(författare)
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New energy strategies in the Swedish pulp and paper industry - The role of national and EU climate and energy policies
- 2011
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Ingår i: Energy Policy. - : Elsevier BV. - 1873-6777 .- 0301-4215. ; 39:3, s. 1439-1449
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Tidskriftsartikel (refereegranskat)abstract
- The Swedish pulp and paper industry has gone through a strategic change in its approach to electricity production and consumption over the past decade. This paper documents this reorientation, which includes increased on-site electricity production, investments and investment plans for wind power, and new partnerships concerning investments in electricity production assets. We also assess the extent to which these changes can be attributed to key energy and climate policies. Our analysis shows that this strategic reorientation has been driven by changes in the underlying economic conditions for the pulp and paper industry, in particular increases in the price of electricity following the Swedish energy market reform in 1996, and the introduction of the EU ETS. The scheme for tradable renewable electricity certificates, on the other hand, has provided a new source of income. While these market-based signals and responses are the most dominant drivers of strategic change, cognitive changes in the pulp and paper industry have also played a role in the strategic reorientation. The cognitive changes concerning the functioning of the electricity market, i.e. the pricing of electricity and influence of the EU ETS, have been particularly important in this regard.
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| 5. |
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| 6. |
- Nilsson, Måns, et al.
(författare)
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Rapid turns in European renewable energy policy: advocacy and framing of the proposed trading of guarantees of origin
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The EU has assumed ambitious targets and strategies for the promotion of renewable sources of energy (RES) binding to all its member states. This report examines the proposed EU-wide policy instrument designed to help achieve the targets on renewable electricity and heat - the trading of Guarantees of Origin (GO). It analyses the rise and fall of the GO trading proposal in the European policy-making machinery during 2007 and 2008. It first discusses its origins, key components and points of contention, and then examines key factors behind the policy development leading first to its development and subsequently to its probable abandonment in 2008. Addressing these factors, the report explores first the near-term policy-making process before and after the proposal on GO trading was tabled in January 2008, focusing on processes in the European bureaucracy and how they were influenced by different interest groups and member state governments. It then looks at how competing policy frames over time have shaped the GO debate. Results show how a strong internal market frame acted as a primary driving force in the Commission throughout the 2000s to promote the GO trading instrument. The subsequent deconstruction of the GO trading proposal can be largely attributed to a) the lack of a strong lobby in favour of GO among member states and interest groups, b) the accumulated experience with and institutionalisation of national RES support policy, and c) growing general political concerns among both member states and EU bodies for supply security, innovation and competitiveness. In the end, the fall of the GO trading instrument is indicative of how the underlying political dividing line between advocates of the European internal market and guardians of national interests has moved in favour of the latter in recent years.
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| 7. |
- Nilsson, Måns, et al.
(författare)
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The rise and fall of GO trading in European renewable energy policy: The role of advocacy and policy framing
- 2009
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Ingår i: Energy Policy. - : Elsevier BV. - 1873-6777 .- 0301-4215. ; 37:11, s. 4454-4462
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines policy processes surrounding the rise and fall of the proposed EU-wide policy instrument designed to help achieve EU´s renewable energy targets – the trading of Guarantees of Origin (GO). It discusses its origins and examines factors in the policy processes over time leading first to its development and then to its rejection. A first analysis looks at the near-term policy-making process before and after the proposal on GO trading in January 2008, focusing on the European law-making institutions and influences of interest groups and member state governments. It then takes a step back and looks over a longer time period at how competing policy frames have shaped the trading debate. Results show how a strong internal market frame acted as a primary driving force in the Commission to promote the GO trading instrument. The rejection of the GO trading proposal in the Council and Parliament can be largely attributed to the lack of a strong lobby in favour of GO, the accumulated experience with and institutionalisation of national RES support policies such as feed-in tariffs, and growing general political concerns for supply security and competitiveness. The framing analysis show that the rise and fall of GO trading embodies a classic conflict between the internal market and the member states’ wish to protect national interests.
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| 8. |
- Punzi, Marisa, et al.
(författare)
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Combined anaerobic-ozonation process for treatment of textile wastewater : Removal of acute toxicity and mutagenicity
- 2015
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Ingår i: Journal of Hazardous Materials. - : Elsevier BV. - 0304-3894 .- 1873-3336. ; 292, s. 52-60
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Tidskriftsartikel (refereegranskat)abstract
- A novel set up composed of an anaerobic biofilm reactor followed by ozonation was used for treatment of artificial and real textile effluents containing azo dyes. The biological treatment efficiently removed chemical oxygen demand and color. Ozonation further reduced the organic content of the effluents and was very important for the degradation of aromatic compounds, as shown by the reduction of UV absorbance. The acute toxicity toward Vibrio fischeri and the shrimp Artemia salina increased after the biological treatment. No toxicity was detected after ozonation with the exception of the synthetic effluent containing the highest concentration, 1. g/l, of the azo dye Remazol Red. Both untreated and biologically treated textile effluents were found to have mutagenic effects. The mutagenicity increased even further after 1. min of ozonation. No mutagenicity was however detected in the effluents subjected to longer exposure to ozone. The results of this study suggest that the use of ozonation as short post-treatment after a biological process can be beneficial for the degradation of recalcitrant compounds and the removal of toxicity of textile wastewater. However, monitoring of toxicity and especially mutagenicity is crucial and should always be used to assess the success of a treatment strategy. © 2015 Elsevier B.V.
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| 9. |
- Lundgren, Karin, 1968, et al.
(författare)
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A model for the anchorage of corroded reinforcement : Validation and application
- 2015
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Ingår i: Concrete - Innovation and Design. - : Technical University of Denmark. ; , s. 135-136, s. 135-136, s. 135-136
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Konferensbidrag (refereegranskat)abstract
- When reinforcement in concrete corrodes, splitting stresses around corroded bars may lead to cover cracking and even cover spalling, affecting the anchorage. The aim of this study was to validate an existing one-dimensional (1D) analysis for anchorage capacity, and to show how it can be applied in assessment of existing bridges. The 1D analysis was validated through comparisons to experiments and detailed 30 finite element analyses. The methodology is exemplified in assessment of two bridges built in the 1960s. The bridges exhibit systematic damage in the form of spalled concrete on the bottom side of the main beams at cast joints where large amounts of reinforcement are spliced. The anchorage length needed to anchor the yield force was calculated from the bond-slip response, using the one-dimensional bond-slip differential equation. The model proved to be easy to use in practical design work. Furthermore, the bridges could be shown to have sufficient capacity, and costly strengthening could be avoided. This work clearly demonstrates the potential to certify sufficient load-carrying capacity of corroded reinforced concrete structures through improved models.
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