| 1. |
- Joona, Therse Björkin, et al.
(författare)
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Influenza vaccination in breast cancer patients during subcutaneous trastuzumab in adjuvant setting
- 2020
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Ingår i: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 184:1, s. 45-52
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite the current recommendation for influenza vaccination in cancer patients with active oncological therapy, limited data are available on the efficacy of vaccination in cancer patients receiving targeted therapies. We aimed to investigate the immunogenicity and tolerability of influenza vaccination in breast cancer patients treated with trastuzumab in adjuvant setting.Methods: A prospective open-label multicenter study was performed including patients with breast cancer during trastuzumab treatment in adjuvant setting and healthy controls. Blood samples were taken before, 4 weeks after, and 12 weeks after a single dose of trivalent influenza vaccine containing inactivated A/California/7/2009 (H1N1) pdm09, A/Hongkong4801/2014 (H3N2), and B/Brisbane/60/2008. Levels of serum antibody titers to hemagglutinin for H1N1 and influenza B strains were measured.Results: Twenty breast cancer patients and 37 controls were included in the study. No difference in seroprotection rate between trastuzumab-treated patients and controls was observed for either H1N1 (100% in both groups) or B strain (78.9% vs. 89.2%,pvalue = 0.423). A statistically significant increase in geometric mean titers from baseline was seen in both groups and was evident both 4 weeks and 12 weeks after vaccination. Adverse events in the trastuzumab-treated group were uncommon and mild with only one serious adverse event not related to vaccination.Conclusion: Breast cancer patients treated with trastuzumab in adjuvant setting seem to benefit from influenza vaccination in terms of immunogenicity without increasing the risk for adverse events. The current data support the recommendation to offer influenza vaccination in breast cancer patients treated with this type of targeted therapy.
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| 2. |
- Mouazzen, Anna-Karin, 1967-, et al.
(författare)
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Adaptation and psychometric evaluation of the Swedish version of the Assessment of Inter professional Team Collaboration Scale (AITCS-S) for use in occupational health services
- 2022
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Ingår i: Journal of Interprofessional Care. - : Taylor & Francis. - 1356-1820 .- 1469-9567. ; 36:6, s. 908-915
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Tidskriftsartikel (refereegranskat)abstract
- Interprofessional team collaboration (ITC) in the Swedish Occupational Health Service is an important part of the service given to the customer. The Occupational Health Service (OHS) could be more competitive if they were able to show how successful is their ITC. The Assessment of Interprofessional Team Collaboration Scale (AITCS) is an instrument that measures ITC in teams working with the client as part of the team. The aim of this study was to adapt the Swedish version of the instrument for use in OHS and to evaluate the psychometric properties of the adapted version and the adapted short version. The study included 472 participants from different OHSs, all members of the trade association of occupational health care in Sweden. Face and content validity of the instrument were assessed, and floor and ceiling effects were measured. Internal consistency was measured with Cronbach's alpha and an exploratory factor analysis was conducted on the 42-item adapted instrument and the short, 24-item version. The exploratory factor analysis gave a three-factor solution with an eigenvalue >1 and explaining a total variance of 57.1% and 62.3% for the short version. The study concludes that AITCS-S-(OHS) as well as the short version, is a reliable and valid questionnaire. Further development of the AITCS-S-(OHS) needs to be undertaken and assessed by confirmatory factor analysis.
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| 3. |
- Nilsson, Per, 1967-, et al.
(författare)
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On the relationship between deterministic and probabilistic reasoning in modelling the chance of a natural phenomenon
- 2012
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Ingår i: Proceedings of Norma 11. - Reykjavík : University of Iceland Press. - 9789979549659
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Konferensbidrag (refereegranskat)abstract
- This study aims at investigating the relationship between deterministic and probabilistic reasoning when students are asked to model and predict the outcomes of a real-world situation involving uncertainty. Twelve students, aged 8-9 years, participated in an outdoor located teaching activity which called for reflection on the growing of sunflowers. Based on the analysis, and previous research, the study suggests to structure an analysis on the relationship between deterministic and probabilistic reasoning according to four analytical relationships: Deterministic model and deterministic behaviour; Deterministic model and probabilistic behaviour; Probabilistic model and deterministic behaviour; Probabilistic model and probabilistic behaviour.
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| 4. |
- Nilsson, Stefan, 1972, et al.
(författare)
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School-aged children's experiences of postoperative music medicine on pain, distress, and anxiety.
- 2009
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Ingår i: Paediatric anaesthesia. - : Wiley. - 1460-9592 .- 1155-5645. ; 19:12, s. 1184-90
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To test whether postoperative music listening reduces morphine consumption and influence pain, distress, and anxiety after day surgery and to describe the experience of postoperative music listening in school-aged children who had undergone day surgery. BACKGROUND: Music medicine has been proposed to reduce distress, anxiety, and pain. There has been no other study that evaluates effects of music medicine (MusiCure) in children after minor surgery. METHODS: Numbers of participants who required analgesics, individual doses, objective pain scores (Face, Legs, Activity, Cry, Consolability [FLACC]), vital signs, and administration of anti-emetics were documented during postoperative recovery stay. Self-reported pain (Coloured Analogue Scale [CAS]), distress (Facial Affective Scale [FAS]), and anxiety (short State-Trait Anxiety Inventory [STAI]) were recorded before and after surgery. In conjunction with the completed intervention semi-structured qualitative interviews were conducted. RESULTS: Data were recorded from 80 children aged 7-16. Forty participants were randomized to music medicine and another 40 participants to a control group. We found evidence that children in the music group received less morphine in the postoperative care unit, 1/40 compared to 9/40 in the control group. Children's individual FAS scores were reduced but no other significant differences between the two groups concerning FAS, CAS, FLACC, short STAI, and vital signs were shown. Children experienced the music as 'calming and relaxing.' CONCLUSIONS: Music medicine reduced the requirement of morphine and decreased the distress after minor surgery but did not else influence the postoperative care.
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| 5. |
- Ahlin, Cecilia, et al.
(författare)
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Cyclin A is a proliferative marker with good prognostic value in node-negative breast cancer
- 2009
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 18:9, s. 2501-2506
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Tidskriftsartikel (refereegranskat)abstract
- Background: Proliferative markers are not recommended as prognostic factors for clinical use in breast cancer due to lack of standardization in methodology. However, proliferation is driving several gene expression signatures emphasizing the need for a reliable proliferative marker IF or clinical use. Studies suggest that cyclin A is a prognostic marker with satisfying reproducibility. We investigated cyclin A as a prognostic marker in node-negative breast cancer using previously defined cutoff values. Patients and Methods: In a case-control study, we defined 190 women who died from breast cancer as cases and 190 women alive at the time for the corresponding case's death as controls. Inclusion criteria were tumor size <= 50 mm, no lymph node metastases and no adjuvant chemotherapy. Tumor tissues were immunostained for cyclin A using commercially available antibodies. Results: We found a statistically significant association between expression of cyclin A and breast cancer death in a univariate model: odds ratio for cyclin A(ave) 2.7 [95% confidence interval (CI), 1.7-4.3] and cyclin A(max) 3.4 (CI, 2.1-5.5). Corresponding odds ratio for Ki67 were Ki67(ave) 1.9 (CI, 1.2-3.1) and Ki67(max) 1.7 (CI, 1.1-2.7) and for grade 3.1 (CI, 1.8-5.1). Cyclin A was strongly correlated to Ki67 and grade why a model including all was not appropriate. Conclusions: Cyclin A is a prognostic factor for breast cancer death in node-negative patients using standardized methodology regarding scoring and cutoff values. Adding cyclin A as a proliferative marker to established clinicopathologic factors will improve the separation of low and high risk breast cancer.
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| 6. |
- Alnervik, Karin, 1958-, et al.
(författare)
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Barn och vårdnadshavares minnen av deltagande i pedagogisk dokumentation
- 2018
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Ingår i: Nordisk Barnehageforskning. - : OsloMet – storbyuniversitetet. - 1890-9167 .- 1890-9167. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Syftet med artikeln är att bidra till kunskapandet om pedagogisk dokumentation med specifikt fokus på dokumentationens betydelse ur ett demokratiperspektiv. Trots många studier kring pedagogisk dokumentation finns det få studier som explicit utgår ifrån barn och vårdnadshavares perspektiv. I artikeln analyseras barns och vårdnadshavares samtal utifrån minnesbilder, vilka framträder i fokusgruppssamtal, från förskoletiden i relation till pedagogiskt dokumentationsarbete. Resultatet visar att den pedagogiska dokumentationspraktiken bidrog till skapandet av en praktikgemenskap på förskolan vilket i sin tur möjliggjorde en demokratisk undervisning.
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| 7. |
- Alnervik, Karin, 1958-, et al.
(författare)
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Do we trust the process? Learning in preschool
- 2014
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Ingår i: Us, Them & Me: Universal, Targeted Or Individuated Early Childhood Programmes. - : European Early Childhood Education Research Association (EECERA).
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Konferensbidrag (refereegranskat)abstract
- The aim is to develop knowledge about young children’s learning of academic concepts as embodied actions and through imagination. In the Swedish preschool curriculum academic subjects such as math and science has been emphasised and the teachers are required to document, what is formulated, as the child’s ‘changed knowing’. There are tendencies that changed knowing is interpreted within two discourses: Goalrational learning versus goalrelational learning. In the former, learning academic subjects becomes a cognitive endeavour similar to teaching older children. In goal relational approaches curriculum goals are interpreted as tools in exploratory processes. We take a sociocultural perspective and apply Wartofsky’s idea of bodily representations and concepts. The empirical data is teachers’ pedagogical documentation in terms of photo images, dialogues between children-children and children-pedagogues and the pedagogues reflections. Interaction and conversation analysis based on the conceptual framework. The pedagogical documentation has been approved for research analysis. We had follow the Swedish ethical rules and guidelines for research in the humanities and social sciences. The result shows that in projects where preschool curriculum goals as, for example math and science, are considered as ‘tools’ and where children are enabled to engage with their whole body and through imagination, scientific concepts become tools in their exploration. An implication is the significance in preschool of taking children’s interest and engagement with their whole body as well as imagination as necessary components in learning processes.
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| 8. |
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| 9. |
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| 10. |
- Andersson, Erik, 1979-, et al.
(författare)
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Kollegialt Lärande i Örebros Skolor – KLÖS-projektet : Hur kan lärares kollegiala lärprocesser stödjas i syfte att skapa hållbara strukturer för utvecklingsarbete?
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet KLÖS har undersökt hur lärares kollegiala lärprocesser kan stödjas i syfte att skapa hållbara strukturer för utvecklingsarbete. Målet var att skapa en Örebromodell för kollegialt lärande. En avslutande reflektion kring resultatet är att etableringen av denna modell kräver ett omfattande engagemang och tar tid att få på plats. Det är vår uppfattning att ett flertal aspekter återstår att undersöka. Bland annat är det intressant att undersöka hur arbetet med det kollegiala lärandet fortskrider på pilotskolan. Frågor som är intressanta är: Vilka faktorer har betydelse för att arbetet med kollegialt lärande ska bli permanent och fungera som ett naturligt sätt att arbeta med utveckling av praktiken? Vad blir resultatet av de utvecklingsomgångar som genomförts? Hur följs detta resultat upp och leder det till bestående gynnsamma förändringar? Frågorna handlar om hållbarhet och därmed om hur projektet går från att vara ett projekt som avslutas och glöms bort till att bli ett levande verktyg för utvecklingsarbete som kan göra en verklig skillnad i och för praktiken över tid. Eftersom mycket tid och resurser används till utvecklingsarbete i skolan är det viktigt att det arbete som görs verkligen leder till en konkret och för verksamheten gynnsam förändring. Det innebär att frågan om utvecklings- arbetets hållbarhet är en av de viktigaste frågorna. Det verktyg som utvecklats i projektet och som kommit att symbolisera det kollegiala arbetet på pilotskolan är KLÖS-hjulet. Frågan om hur KLÖS-hjulet 2.0 kan utvecklas och anpassas så att det verkligen blir ett flexibelt och användbart verktyg för att stötta det kollegiala lärandet är kanske den alla viktigaste konkreta frågan. Frågor som är besläktade med frågan om hållbarhet är de som syftar till att undersöka hur det kollegiala lärandet kan bli mer robust. Till dessa hör frågor om hur lärledarens roll kan förstärkas, hur verktyg som stöttar lärares observation och analys av den egna verksamheten kan designas, hur ansvar och engagemang på alla nivåer kan förstärkas och bli synligt samt hur arbetet med kollegialt lärande kan utvärderas. Vi har under projektets gång sett hur lärare behöver stöd i arbetet med att systematiskt identifiera behov i verksamheten för att sedan utforska möjligheter att utveckla och förändra praktiken. Medverkan från forskare som ställt frågor, problematiserat och belyst olika perspektiv har i flera fall varit avgörande för hur ett utvecklingsbehov har identifierats, avgränsats och formulerats som en undersökningsbar fråga. Det är av avgörande betydelse att utvecklingsarbetet inte står och faller med denna medverkan. Verksamheten måste själv ta fram strukturer för hur lärare och lärledare får ett tillfredsställande stöd i sitt utvecklingsarbete så att de har möjlighet att göra kollegialt lärande till en naturlig del av sitt arbete där de känner sig så bekanta med KLÖS-hjulet att de själva kan ställa de frågor som krävs. Således behöver många funktioner, både centralt och lokalt samverka för att vidareutveckla och stötta kollegialt lärande för att utveckla undervisningen i Örebro skolor.
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