| 1. |
- Bergdahl, Jan, et al.
(författare)
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Treatment of chronic stress in employees: Subjective, cognitive, and neural correlates.
- 2005
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 46:5, s. 395-402
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Tidskriftsartikel (refereegranskat)abstract
- This study reports the effect of an affect-focused intervention program, the Affect School (AS), on stress, psychological symptoms, cognitive functioning and neural activity. Fifty employees in social service and education, with high levels of chronic stress, were randomly divided into a treatment (N=27) and control (N=23) group. Complete sets of data were available in 20 participants in the treatment group and in 17 in the control group. The Percieved Stress Questionnaire assessed stress and the Symptom Chech List-90 psychological symptoms before and after the treatment. Episodic-memory functioning under focussed and divided attention conditions was also assessed. Prior and after the AS, seven participants in the treatment group were studied with fMRI during episodic memory processing. After the AS there was a reduction in stress and psychological symptoms for the treatment group but not in the control group. The controls showed a reduction in episodic memory functioning whereas the performance of the treatment group remained intact. The fMRI scanning indicated a qualitative change in the neural network subserving episodic memory. These preliminary results suggest that the AS is effective on individuals with high stress.
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| 2. |
- Bergdahl, Maud, et al.
(författare)
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Difference in apolipoprotein E type 4 allele (APOE ɛ4) among dentate and edentulous subjects
- 2008
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Ingår i: Gerodontology. - : Wiley. - 0734-0664 .- 1741-2358. ; 25:3, s. 179-186
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (ɛ4) was associated with edentulousness even when certain factors were controlled.Background: The APOE are important in lipid homeostasis, and APOE ɛ4 has been found in many diseases and to have a negative impact on longevity. Tooth loss is more common in ill aged subjects with low income and education.Materials and methods: In a population-based study involving 1860 subjects between 35 and 85 years 1321 dentate (mean age = 54; 54% women, 46% men) and 539 edentulous (mean age = 72; 62% women, 38% men) subjects were studied. Logistic regression was performed with dentate/edentulous as dependent variables and years of education, socio-economic status, social network, stress level, handicap from birth, 23 various diseases and APOE ɛ4 as covariates. Thereafter, APOE ɛ4 frequencies were studied in 342 dentate and 336 edentulous subjects 50–85 years of age. The subjects were matched with regard to age, gender, years of education, living condition, stress level, handicap from birth and 23 various diseases.Results: APOE allele frequency in the total group was ɛ2 = 7.8%, ɛ3 = 76.4% and ɛ4 = 15.8%. Age, living condition, years of education and APOE ɛ4 were significant covariates in edentulous subjects (p ≤ 0.001). APOE ɛ4 in the matched groups revealed significant differences between the dentate group and the edentulous group (χ2 = 5.68; p = 0.017). There was no group effect (F(29,648) = 0.849; p < 0.696; Wilks' lambda = 0.963). In the dentate group, the frequencies of APOE were: ɛ2 = 8.8%, ɛ3 = 77.9% and ɛ4 = 13.3%. Corresponding frequencies of APOE in the edentulous group were: ɛ2 = 6.6%, ɛ3 = 75.4% and ɛ4 = 18.0%.Conclusion: Despite matching both groups with regard to different background factors, the edentulous group had a higher frequency of APOE ɛ4 than the dentate group. Thus, genetic factors might contribute to greater risk in developing complex oral diseases leading to tooth loss or just be an indication that the subjects in our study carrying APOE ɛ4 are more fragile.
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| 3. |
- Bergdahl, Maud, et al.
(författare)
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Natural teeth and cognitive function in humans
- 2007
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 48:6, s. 557-565
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Tidskriftsartikel (refereegranskat)abstract
- A number of neurobiological, psychological and social factors may account for cognitive impairment. In animal studies a relation between dental status and cognitive performance has been found. It is unclear whether such a relation exists for humans. In a first step we compared the performance of 1,351 participants (53% women, 47% men; age M = 54.0) with natural teeth to 487 edentulous participants (59% women, 41% men; age M = 71.3) on 12 cognitive tests. The natural teeth group had a lower mean age, fewer women, more years of education, higher mini-mental state (MMSE), and performed significantly higher on several cognitive tests. In a subsequent analysis, the cognitive performance of a subset of the participants (50–85 years) was examined. In this analysis, 211 had natural dentition and 188 were edentulous. The groups were matched for gender, age, social variables, diseases, stress and MMSE. The cognitive disadvantage of the edentulous group was still apparent. The results suggest that functional natural teeth relate to relatively preserved cognitive functioning in older age.
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| 4. |
- Bergdahl, Maud, et al.
(författare)
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Natural teeth and preserved cognitive function in humans.
- 2007
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 48, s. 557-565
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Tidskriftsartikel (refereegranskat)abstract
- A number of neurobiological, psychological and social factors may account for cognitive impairment. In animal studies a relation between dental status and cognitive performance has been found. It is unclear whether such a relation exists for humans, even though many older adults have poor oral health. In a large-scale population-based study involving individuals between the ages 35 to 90 years, 1366 subjects with natural teeth (55% women, 45% men; age M=56.3) and 510 edentulous subjects (61% women, 39% men; age M=73.4) were compared regarding their performance on twelve cognitive tests. In a subsequent analysis, cognitive performance was examined while the natural teeth group (N=239; 51% women, 49% men; age M=69.2) and the edentulous group (N=216; 54% women, 46% men; age M=68.8) were matched with regard to age, gender, years of education, MMSE, stress level and various diseases. The natural teeth group had a lower mean age, more formal education, reported less back pain, and performed significantly higher on several cognitive tests. After matching the groups, the natural teeth group performed significantly higher on multiple cognitive tests. The results suggest that functional natural teeth relate to relatively preserved cognitive functioning in older age, which underlines the necessity of adequate dental care in the elderly.
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| 5. |
- Hansson, Patrik, et al.
(författare)
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Relationship between natural teeth and memory in a healthy elderly population
- 2013
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Ingår i: European Journal of Oral Sciences. - : Wiley. - 0909-8836 .- 1600-0722. ; 121:4, s. 333-340
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between mastication and cognitive function remains unclear, but both animal and experimental human studies suggest a possible causal relationship. In the present study it was hypothesized that natural teeth are of importance for hippocampus-based cognitive processes, such as episodic long-term memory. A population-based sample of 273 participants (55-80yr of age; 145 women) was investigated in a cross-sectional study. The participants underwent health assessment, completed a battery of cognitive tests, and took part in an extensive clinical oral examination. The number of natural teeth contributed uniquely and significantly to explaining variance (3-4%) in performance on measures of episodic memory and semantic memory over and above individual differences in age, years of education, gender, occupation, living conditions, and medical history. The number of natural teeth did not have an influence on the performance of measures of working memory, visuospatial ability, or processing speed. Within the limitations of the current study, a small, but significant, relationship between episodic memory and number of natural teeth is evident.
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| 6. |
- Mousavi, Malahat, et al.
(författare)
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Serum metabolomic biomarkers of dementia
- 2014
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Ingår i: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 4:2, s. 252-62
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Tidskriftsartikel (refereegranskat)abstract
- Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.
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| 7. |
- Sundström, Anna, et al.
(författare)
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Amalgam-related complaints and cognition
- 2011
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Ingår i: Dental Abstracts. - : Elsevier. - 0011-8486. ; 56:2, s. 83-83
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Sundström, Anna, et al.
(författare)
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Amalgam-related complaints and life events
- 2011
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Ingår i: Dental Abstracts. - : Elsevier. - 0011-8486. ; 56:5, s. 261-262
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Sundström, Anna, 1969-, et al.
(författare)
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Cognitive Status in Persons with Amalgam-related Complaints
- 2010
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Ingår i: Journal of Dental Research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 89:11, s. 1236-1240
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Tidskriftsartikel (refereegranskat)abstract
- Self-reported cognitive symptoms are frequent in persons with amalgam-related complaints, but few studies have focused on their cognitive function. The aim was to examine a symptom profile and whether participants with amalgam-related complaints have cognitive deficits in comparison with control individuals. We drew 342 participants with amalgam-related complaints and 342 one-to-one matched control individuals from a longitudinal population-based study. For 81 of the participants with amalgam-related complaints and controls, data were available approximately five years before the onset of complaints, making a longitudinal analysis possible. All participants were assessed by a self-reported health questionnaire and a comprehensive cognitive test battery. The participants with amalgam-related complaints reported more symptoms, mainly musculoskeletal and neuropsychological, compared with control individuals (p < 0.001). The results revealed no significant difference between the amalgam and control group, either cross-sectionally or longitudinally, for any of the cognitive tests. These results suggest that cognitive decline is not associated with amalgam-related complaints.
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| 10. |
- Sundström, Anna, 1969-, et al.
(författare)
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Stressful negative life events and amalgam-related complaints
- 2011
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Ingår i: Community Dentistry and Oral Epidemiology. - : Wiley. - 0301-5661 .- 1600-0528. ; 39:1, s. 12-18
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The role of stressful life events in the onset of self-reported amalgam-related complaints is unclear. The aim of this study was to examine the relationship between life events and amalgam-related complaints. Method: The participants were selected from a longitudinal population-based study. One-to-one matching of 337 participants with amalgam-related complaints to 337 participants without such complaints was performed. For 81 of the participants with amalgam-related complaints and their matched controls, data was also available approximately 5 years before the onset of complaints, making longitudinal analysis possible. All participants completed questionnaires assessing the occurrence of 55 life events. Results: The results showed that many participants with amalgam-related complaints experienced negative life events before and at the onset of amalgam-related complaints. They also reported more unexpected and uncontrollable events difficult to adjust to in comparison with controls. The groups did not differ on positive or neutral life events. Somatic illness or surgical operation was the most common life event. Death of a very close family member and a major change in financial situation were also commonly reported. Conclusions: This study indicates that adverse negative life events could play a vital role in understanding and explaining amalgam-related complaints.
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