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- Hillgren, Per-Anders, et al.
(author)
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Glossary: Collaborative Future-Making
- 2020
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Other publication (other academic/artistic)abstract
- Collaborative Future-Making is a research platform at the Faculty of Culture and Society at Malmö University that is concerned with how to envision, elaborate and prototype multiple, inclusive, and sustainable futures. The platform gathers around 20 researchers that share a methodological interest in how critical perspectives from the humanities and social sciences can be combined with the constructive and collaborative aspects of making and prototyping in design research.The research centers around two major themes:Critical imagination, which focuses on how basic assumptions, norms and structures can be challenged to widen the perspectives on what can constitute socially, culturally, ecologically and economically sustainable and resilient futures.Collaborative engagements, which focuses on how we can set up more inclusive collaborations to prototype and discuss alternative futures, engaging not only professionals and policy makers but also citizens and civil society.During 2019 the research group set out to make a shared glossary for collaborative future-making. The glossary is multiple in purpose and exists in several versions. Hopefully there will be more to come. At first, the making and articulation of the glossary was used within the research group as an exercise to share concepts that we found central to collaborative future-making, coming from different disciplines. This published version of the glossary was assembled to be used during a workshop called Imagining Collaborative Future-Making, which gathered a group of international researchers from different disciplines.The collection of concepts reflects the heterogeneous and diverse character of the research group and a strong belief in that plurality regarding ontologies and epistemologies will be crucial to be able to handle the multiple uncertainties and complex challenges we have to face in the future. Some of the concepts are already well established within different research communities, but gain a specific meaning in relation to the research area. Others are more preliminary attempts to advance our understanding or probe into new potential practices within collaborative future-making. In that sense the concepts in the glossary are well situated and grounded in past and ongoing research within this research group, at the same time as they are meant to suggest, propose and point towards practices and approaches yet to come.The concepts in this glossary are not only meant to be descriptive but also performative. In that sense, assembling and circulating this glossary is part of collaborative future-making. As pointed out by Michelle Westerlaken in her articulation of “Doing Concepts” (see page 15), “...without proposing, critiquing, or working towards a common or uncommon understanding of certain concepts, it becomes impossible to ‘make futures’ in any deliberate fashion.”
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- Johansson, Jeaneth, et al.
(author)
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Project: PanLab II
- 2010
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Other publication (pop. science, debate, etc.)abstract
- Det övergripande målet med PanLabII är att utveckla och förbättra de mekanismer och teknologier som möjliggör skapandet av en federation av existerande testbäddar som skapar ett ökat värde för användare av existerande lokala testbäddar samt visa en federationen som en modell som möjliggör etablerandet av långsiktiga, livskraftiga och storskaliga testinfrastrukturer för telekom teknologier, tjänster och applikationer i Europa. Detta Intergrated Projekt är finansierat av EU:s sjunde ramprogram.
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- Johansson, Jeaneth, et al.
(author)
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Projekt: MeMo - Meta-affärsmodell för mobila tjänster
- 2010
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Other publication (pop. science, debate, etc.)abstract
- Syftet med detta projekt är att identifiera affärsmodeller för mobila tjänster och att föreslå en meta-affärsmodell som kan tillvarata affärspotential genom samverkan mellan aktörer som tjänsteleverantörer, tjänsteförmedlare och kunder i ett större nätverk. I projektet samverkar forskare från fem forskningsområden (industriell marknadsföring, e-handel, redovisning & styrning, informatik, och industriell organisation) vid Luleå tekniska universitet (LTU) för att från sina respektive angreppsvinklar: Identifiera och beskriva affärsmodeller för mobila tjänster. Föreslå en meta-affärsmodell för att möjliggöra effektiva framtida affärer för mobila tjänsteleverantörer. Samla insamlade erfarenheter i ett white paper som kananvändas som stöd för utveckling av framgångsrika affärsmodeller för de deltagande företagen. Synliggöra vetenskapliga resultat i publikationer och presentationer. MeMo-projektet är finansierat av VINNOVA och genomförs i samarbete mellan LTU och TeliaSonera och ett antal av dess nuvarande och framtida tjänsteleverantörer. Genom Centrum för Distansöverbryggande Teknik (CDT) vid LTU och dess Living Lab-nätverk, når projektet ut till stora grupper av slutanvändare.
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- Nilsson, Alexandra Rundberg, et al.
(author)
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IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance
- 2023
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Other publication (other academic/artistic)abstract
- Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need to be fully elucidated. Rather than focusing on specific inflammatory stimuli, we here investigated the role of transcription factor Interferon (IFN) regulatory factor 1 (IRF1), which receives input from several inflammatory signaling pathways. We identify IRF1 as a master HSC regulator. IRF1 loss impairs HSC self-renewal, increases stress-induced cell cycle activation, and confers apoptosis resistance. Transcriptomic analysis revealed an aged, inflammatory signature devoid of IFN signaling with reduced megakaryocytic/erythroid priming and antigen presentation in IRF1-deficient HSCs. Finally, we conducted IRF1-based AML patient stratification to identify groups with distinct proliferative, survival and differentiation features, overlapping with our murine HSC results. Our findings position IRF1 as a pivotal regulator of HSC preservation and stress-induced responses.Competing Interest StatementThe authors have declared no competing interest.
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| 10. |
- Nilsson, Magnus, et al.
(author)
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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease : exploration of P2 quinazoline substituents.
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Other publication (other academic/artistic)abstract
- Novel NS3/4A protease inhibitors comprising quinazoline derivatives as P2 substituent were synthesized. High potency inhibitors displaying advantageous PK properties have been obtained through the optimization of quinazoline P2 substituents in three series of macrocyclic P2 cyclopentane dicarboxylic acid and P2 proline urea motifs. For the quinazoline moiety it was found that 8-methyl substitution for the P2 cyclopentane dicarboxylic acid series improved on the stability in human liver microsomes. By comparison, the proline urea series displayed advantageous Caco-2 permeability over the cyclopentane series. properties were assessed in rat on selected compounds. Excellent exposure and liver–to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series. In vivo pharmacokinetic properties were assessed in rat on selected compounds. Excellent exposure and liver–to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series.
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