| 1. |
- Nylander, Ola, 1957, et al.
(författare)
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Bostadens rum. Chalmersarkitekter om bostadens kvalitéer
- 2007
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Spaces of Residence -Chalmers architects on residential qualitiesEds. Ola Nylander, Sten Gromark, Fredrik Nilsson & Christina Redvall, Axl books, Stockholm 2007, Swedish,With contributions by Ola Nylander, Sten Gromark, Fredrik Nilsson, Christina Redvall, Kaj Granath, Sören Olson, Katrin Paadam, Anna Eriksson, Karin Drakenberg, Håkan Trygged, Maria Sandqvist, Petter Lodmark & Jenny Ström Hansson.For most human beings the residence represents without any doubt the most intimate relation to and the most fundamental encounter with architecture. Material properties and organizational structures of residential spaces highly condition our ways of residing. And yet our ways of relating to residence shape the ways the built structures are identified and created, also based upon a continuity of our evolving desires and changing demands, ultimately bringing new form to our residential spaces. When emerging societal and cultural transformations profoundly alters our perceptions of traditional residential typologies and conventions the field is open for radically new spatial concepts to be sometimes suddenly born. University education in housing and residential design is, on the one hand, often focused on the preservation of experiences and genuine knowledge acquired in the past and, on the other hand, at the best simultaneously looking forward towards continuously ongoing acts of twofold and multifaceted social and architectural invention. This necessary double way of looking is one of the major ambitions behind the book Spaces of Residence, where we want to present moments, fragments and excerpts as reflections emanating from the constant and long term evolution of a well established activity of combined training and research on housing and residential architecture at Chalmers School of Architecture, Göteborg, Sweden.
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| 2. |
- Montelius, Mikael, 1979, et al.
(författare)
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Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor.
- 2018
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Ingår i: Translational oncology. - : Elsevier BV. - 1936-5233. ; 11:2, s. 193-204
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic resonance (MR) methods enable noninvasive, regional tumor therapy response assessment, but associations between MR parameters, underlying biology, and therapeutic effects must be investigated.The aim of this study was to investigate response assessment efficacy and biological associations of MR parameters in a neuroendocrine tumor (NET) model subjected to radionuclide treatment.Twenty-one mice with NETs received 177Lu-octreotate at day 0. MR experiments (day -1, 1, 3, 8, and 13) included T2-weighted, dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) and relaxation measurements (T1/T2*). Tumor tissue was analyzed using proteomics. MR-derived parameters were evaluated for each examination day and for different radial distances from the tumor center. Response assessment efficacy and biological associations were evaluated using feature selection and protein expression correlations, respectively.Reduced tumor growth rate or shrinkage was observed until day 8, followed by reestablished growth in most tumors. The most important MR parameter for response prediction was DCE-MRI-derived pretreatment signal enhancement ratio (SER) at 40% to 60% radial distance, where it correlated significantly also with centrally sampled protein CCD89 (association: DNA damage and repair, proliferation, cell cycle arrest). The second most important was changed diffusion (D) between day -1 and day 3, at 60% to 80% radial distance, where it correlated significantly also with peripherally sampled protein CATA (association: oxidative stress, proliferation, cell cycle arrest, apoptotic cell death).Important information regarding tumor biology in response to radionuclide therapy is reflected in several MR parameters, SER and D in particular. The spatial and temporal information provided by MR methods increases the sensitivity for tumor therapy response.
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