| 1. |
- Berglund, U. W., et al.
(författare)
-
Validation and development of MTH1 inhibitors for treatment of cancer
- 2016
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 27:12, s. 2275-2283
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cancer cells, challenging the utility of MTH1 inhibition as a target for cancer treatment. Material and methods: Human cancer cell lines were exposed in vitro to MTH1 inhibitors or depleted of MTH1 by siRNA or shRNA. 8-oxodG was measured by immunostaining and modified comet assay. Thermal Proteome profiling, proteomics, cellular thermal shift assays, kinase and CEREP panel were used for target engagement, mode of action and selectivity investigations of MTH1 inhibitors. Effect of MTH1 inhibition on tumour growth was explored in BRAF V600E-mutated malignant melanoma patient derived xenograft and human colon cancer SW480 and HCT116 xenograft models. Results: Here, we demonstrate that recently described MTH1 inhibitors, which fail to kill cancer cells, also fail to introduce the toxic oxidized nucleotides into DNA. We also describe a new MTH1 inhibitor TH1579, (Karonudib), an analogue of TH588, which is a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo. Conclusion: We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.
|
|
| 2. |
- Bender, R., et al.
(författare)
-
Corrosion challenges towards a sustainable society
- 2022
-
Ingår i: Materials and corrosion - Werkstoffe und Korrosion. - : Wiley. - 0947-5117 .- 1521-4176. ; 73:11, s. 1730-1751
-
Tidskriftsartikel (refereegranskat)abstract
- A global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate-resilient energy systems and infrastructures brings with it a long-term direction, so as a result the long-term behaviour of structural materials (mainly metals and alloys) becomes a major prospect. With this in mind “Corrosion Challenges Towards a Sustainable Society” presents a series of cases showing the importance of corrosion protection of metals and alloys in the development of energy production to further understand the science of corrosion, and bring the need for research and the consequences of corrosion into public and political focus. This includes emphasis on the limitation of greenhouse gas emissions, on the lifetime of infrastructures, implants, cultural heritage artefacts, and a variety of other topics.
|
|
| 3. |
|
|
| 4. |
- Hamnerius, Yngve, 1950, et al.
(författare)
-
Design of Safe Wireless Power Transfer Systems for Electric Vehicles
- 2018
-
Ingår i: 2018 2nd URSI Atlantic Radio Science Meeting, AT-RASC 2018. - 9789082598735
-
Konferensbidrag (refereegranskat)abstract
- Wireless charging of electric vehicles is convenient but in order to make it safe the exposure of humans to electromagnetic fields must be below acceptable limits. We have designed a prototype system that transmits 3 kW with an efficiency of 85% where the magnetic fields around and inside the vehicle are below the EU council recommendation of 6.25μT at 85 kHz.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Hällström, J, et al.
(författare)
-
International comparison of software for calculation of lightning impulse parameters based on a new processing algorithm
- 2007
-
Konferensbidrag (refereegranskat)abstract
- A new algorithm has been proposed to calculate the parameters of full lightning voltage impulses. The new algorithm enables the application of the test voltage factor (also referred to as k-factor in some literatures) for calculation of the equivalent test voltage of impulses with superimposed oscillations/overshoots. The new algorithm at the same time provides a robust procedure for obtaining time parameters of the impulses from not only smooth waveforms but also waveforms with varying degrees of distortions in the front part of the impulses. These distortions include oscillations on the impulse front and overshoots in the peak region. A critical part of the new algorithm is a 4-parameter fitting procedure to obtain the base curve, which is used for calculation of the test voltage curve. Another important part of the algorithm is applying a filtering procedure in the calculation of the test voltage curve. The new algorithm was tested in different laboratories using different programming languages and different techniques for realising the fitting and filtering routines. The paper reports the results obtained from the participating laboratories using the proposed algorithm. The results obtained by the participating laboratories using existing software based on the requirement of IEC 60060-1: 1989 were also compared. It is anticipated that the results can serve as a part of the basis for a new procedure for determination of lightning impulse parameters in the revised IEC 60060-1.
|
|
| 8. |
- Luks, T., et al.
(författare)
-
Contact stress distribution and roll surface temperatures in the roll gap analyzed with different sensors
- 2014
-
Ingår i: La Metallurgia Italiana. - : Associazione Italiana di Metallurgia. - 0026-0843. ; 106:1, s. 19-25
-
Tidskriftsartikel (refereegranskat)abstract
- In this work, the contact stresses and temperatures during hot and cold rolling have been measured. A work roll containing three different sensors was used for the measurements. There were two contact devices for directly measuring forces and one temperature sensor. One sensor was the "ROLLSURF" sensor. Results obtained with this sensor have been presented earlier [1-3], The measurement principle is based on deformation measurements with strain gauges which were placed on an internal cradle-type roll insert. The second sensor was a friction pin sensor. The forces on the top of the pin were measured by three axis piezoelectric-transducers. The pin sensor was mounted inside the work roll opposite to the ROLLSURF sensor. The third sensor was a thermocouple placed next to the pin sensor. The temperatures were measured very close to the roll surface. The surface boundary conditions including the heat flux and surface temperatures were computed using inverse modelling calculations developed at Brno University of Technology. The main task of this paper is to show a comparison of the contact forces and contact length measured with the strain-gauge sensor and the pin-sensor.
|
|
| 9. |
- Lundgren, Joakim, et al.
(författare)
-
Methanol production from steel-work off-gases and biomass based synthesis gas
- 2013
-
Ingår i: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 112, s. 431-439
-
Tidskriftsartikel (refereegranskat)abstract
- Off-gases generated during steelmaking are to a large extent used as fuels in process units within the plant. The surplus gases are commonly supplied to a plant for combined heat and power production. The main objective of this study has been to techno-economically investigate the feasibility of an innovative way of producing methanol from these off-gases, thereby upgrading the economic value of the gases. Cases analyzed have included both off-gases only and mixes with synthesis gas, based on 300MWth of biomass. The SSAB steel plant in the town of Luleå, Sweden has been used as a basis. The studied biomass gasification technology is based on a fluidized-bed gasification technology, where the production capacity is determined from case to case coupled to the heat production required to satisfy the local district heating demand. Critical factors are the integration of the gases with availability to the synthesis unit, to balance the steam system of the biorefinery and to meet the district heat demand of Luleå. The annual production potential of methanol, the overall energy efficiency, the methanol production cost and the environmental effect have been assessed for each case. Depending on case, in the range of 102,000-287,000ton of methanol can be produced per year at production costs in the range of 0.80-1.1EUR per liter petrol equivalent at assumed conditions. The overall energy efficiency of the plant increases in all the cases, up to nearly 14%-units on an annual average, due to a more effective utilization of the off-gases. The main conclusion is that integrating methanol production in a steel plant can be made economically feasible and may result in environmental benefits as well as energy efficiency improvements. © 2013 Elsevier Ltd.
|
|
| 10. |
- Majee, Subimal, 1984-, et al.
(författare)
-
Highly Conductive Films by Rapid Photonic Annealing of Inkjet Printable Starch–Graphene Ink
- 2021
-
Ingår i: Advanced Materials Interfaces. - : John Wiley and Sons Inc. - 2196-7350. ; 9:5
-
Tidskriftsartikel (refereegranskat)abstract
- A general formulation engineering method is adopted in this study to produce a highly concentrated (≈3 mg mL−1) inkjet printable starch–graphene ink in aqueous media. Photonic annealing of the starch–graphene ink is validated for rapid post-processing of printed films. The experimental results demonstrate the role of starch as dispersing agent for graphene in water and photonic pulse energy in enhancing the electrical properties of the printed graphene patterns, thus leading to an electrical conductivity of ≈2.4 × 104 S m−1. The curing mechanism is discussed based on systematic material studies. The eco-friendly and cost-efficient approach presented in this work is of technical potential for the scalable production and integration of conductive graphene inks for widespread applications in printed and flexible electronics.
|
|
