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The Alzheimer's Ass...
The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Batrla, Richard (author)
- Novartis Pharma AG
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- Brix, Britta (author)
- Euroimmun Medizinische Labordiagnostika AG
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- Carrillo, Maria C. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
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- Corradini, Veronika (author)
- Roche Diagnostics International
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- Edelmayer, Rebecca M. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
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- Esquivel, Rianne N. (author)
- Fujirebio Diagnostics Inc
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- Hall, Christina (author)
- Fujirebio Diagnostics AB
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- Lawson, John (author)
- Fujirebio Diagnostics Inc
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- Bastard, Nathalie Le (author)
- Fujirebio Europe N.V.
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- Molinuevo, José Luis (author)
- Hospital Clínic of Barcelona,Pasqual Maragall Foundation for Research on Alzheimer
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- Nisenbaum, Laura K. (author)
- Biogen, Inc.
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- Rutz, Sandra (author)
- Roche Diagnostics, Germany
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- Salamone, Salvatore J. (author)
- Saladax Biomedical, Inc.
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- Teunissen, Charlotte E. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Traynham, Christopher (author)
- Fujirebio Diagnostics Inc
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- Umek, Robert M. (author)
- Meso Scale Diagnostics LLC
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- Vanderstichele, Hugo (author)
- Biomarkable bv Consulting
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- Vandijck, Manu (author)
- Fujirebio Diagnostics Inc
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- Wahl, Simone (author)
- Saladax Biomedical, Inc.
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- Weber, Christopher J. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,University College London,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2021-03-31
- 2021
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 17:9, s. 1575-1582
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Abstract
Subject headings
Close
- The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between-center differences in pre-analytical procedures may contribute to variability in measurements across laboratories. To resolve this issue, a workgroup was led by the Alzheimer's Association with experts from both academia and industry. The aim of the group was to develop a simplified and standardized pre-analytical protocol for CSF collection and handling before analysis for routine clinical use, and ultimately to ensure high diagnostic performance and minimize patient misclassification rates. Widespread application of the protocol would help minimize variability in measurements, which would facilitate the implementation of unified cut-off levels across laboratories, and foster the use of CSF biomarkers in AD diagnostics for the benefit of the patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid Beta
- Biomarkers
- Cerebrospinal Fluid
- CSF
- Diagnosis
- Fresh CSF
- Frozen CSF
- Handling
- Measurements
- Pre-Analytical
- Tau
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Hansson, Oskar
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Batrla, Richard
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Brix, Britta
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Carrillo, Maria ...
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Corradini, Veron ...
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Edelmayer, Rebec ...
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show more...
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Esquivel, Rianne ...
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Hall, Christina
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Lawson, John
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Bastard, Nathali ...
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Molinuevo, José ...
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Nisenbaum, Laura ...
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Rutz, Sandra
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Salamone, Salvat ...
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Teunissen, Charl ...
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Traynham, Christ ...
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Umek, Robert M.
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Vanderstichele, ...
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Vandijck, Manu
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Wahl, Simone
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Weber, Christoph ...
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Zetterberg, Henr ...
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Blennow, Kaj
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University
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University of Gothenburg