Differential molecular and behavioural response to L-DOPA in mice injected with 6-hydroxydopamine in the striatum or in the medial forebrain bundle

• Unilateral lesions of nigrostriatal dopamine ( DA) pathways with 6-hydroxydopamine (6-OHDA) can be used to obtain a model of Parkinson's disease in the mouse. In the present study we examine two types of unilateral 6-OHDA lesions in the mouse for their ability to induce stable motor deficits and supersensitive molecular and behavioural response to L-DOPA.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

L-DOPA

6-OHDA

mice

Publikations- och innehållstyp

kon (ämneskategori)

vet (ämneskategori)