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- In ’t Veld, Sjors G.J.G., et al.
(författare)
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Detection and localization of early- and late-stage cancers using platelet RNA
- 2022
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Ingår i: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 40:9, s. 999-1009.e6
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Tidskriftsartikel (refereegranskat)abstract
- Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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- Kaiser, Eurika, et al.
(författare)
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Cluster-based reduced-order modelling of a mixing layer
- 2014
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Ingår i: Journal of Fluid Mechanics. - : Cambridge University Press (CUP). - 0022-1120 .- 1469-7645. ; 754, s. 365-414
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Tidskriftsartikel (refereegranskat)abstract
- We propose a novel cluster-based reduced-order modelling (CROM) strategy for unsteady flows. CROM combines the cluster analysis pioneered in Gunzburger’s group (Burkardt, Gunzburger & Lee, Comput. Meth. Appl. Mech. Engng, vol. 196, 2006a, pp. 337–355) and transition matrix models introduced in fluid dynamics in Eckhardt’s group (Schneider, Eckhardt & Vollmer, Phys. Rev. E, vol. 75, 2007, art. 066313). CROM constitutes a potential alternative to POD models and generalises the Ulam–Galerkin method classically used in dynamical systems to determine a finite-rank approximation of the Perron–Frobenius operator. The proposed strategy processes a time-resolved sequence of flow snapshots in two steps. First, the snapshot data are clustered into a small number of representative states, called centroids, in the state space. These centroids partition the state space in complementary non-overlapping regions (centroidal Voronoi cells). Departing from the standard algorithm, the probabilities of the clusters are determined, and the states are sorted by analysis of the transition matrix. Second, the transitions between the states are dynamically modelled using a Markov process. Physical mechanisms are then distilled by a refined analysis of the Markov process, e.g. using finite-time Lyapunov exponent (FTLE) and entropic methods. This CROM framework is applied to the Lorenz attractor (as illustrative example), to velocity fields of the spatially evolving incompressible mixing layer and the three-dimensional turbulent wake of a bluff body. For these examples, CROM is shown to identify non-trivial quasi-attractors and transition processes in an unsupervised manner. CROM has numerous potential applications for the systematic identification of physical mechanisms of complex dynamics, for comparison of flow evolution models, for the identification of precursors to desirable and undesirable events, and for flow control applications exploiting nonlinear actuation dynamics.
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- Luederitz, Christopher, et al.
(författare)
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A review of urban ecosystem services: six key challenges for future research
- 2015
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Ingår i: Ecosystem Services. - : Elsevier BV. - 2212-0416. ; 14, s. 98-112
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Forskningsöversikt (refereegranskat)abstract
- Global urbanization creates opportunities and challenges for humanwell-being and transition towards sustainability. Urban areas are human-environment systems that depend fundamentally on ecosystems, and thus require an understanding of the management of urban ecosystem services to ensure sustainable urban planning. The purpose of this study is to provid easy stematic review of urban ecosystem sservices research, which addresses the combined domain of ecosystem services and urban development. We examined emerging trends and gaps in how urban ecosystem services are conceptualized in peer-reviewed case study literature, including the geographical distribution ofresearch,the development and use of the urban ecosystem services concept,and thei nvolvement of stakeholders. We highlight six challenges aimed at strengthening the concept's potential to facilitate meaningful inter-and transdis ciplinary work for ecosystem services research and planning. Achieving a cohesive conceptual approach in ther esearch field will address(i)the need for more extensive spatial and contextual coverage,(ii) continual clarification of definitions, (iii)recognition of limited datat ransferability,(iv)more comprehensive stakeholder involvement,(v)more integrated research efforts,and(vi)translation of scientific findings into actionable knowledge,feeding information back into planning and management.We conclude with recommendations for conducting further research while incorporating these challenges.
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