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Swedish children wi...
Swedish children with hereditary angioedema report good overall health and quality of life despite symptoms
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- Nygren, Anders (författare)
- Karolinska Institute, Sweden; Karolinska University Hospital, Sweden
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- Nordenfelt, Patrik (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,County Hospital Ryhov, Sweden
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- Lindfors, Anders (författare)
- Karolinska Institutet
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- Mallbris, Lotus (författare)
- Karolinska Institutet
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- Björkander, Jan Fredrik (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Futurum Academic Health and Care, Sweden
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- Wahlgren, Carl-Fredrik (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-02-23
- 2016
- Engelska.
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Ingår i: Acta Paediatrica. - : WILEY-BLACKWELL. - 0803-5253 .- 1651-2227. ; 105:5, s. 529-534
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AimFew studies have been published on children with hereditary angioedema (HAE), an autosomal dominant disease caused by mutations on chromosome 11. This study explored various aspects of the disease in the Swedish paediatric population. MethodsA retrospective questionnaire was sent to all 36 Swedish children known to have HAE, and a physician carried out follow-up telephone interviews. ResultsMost of the questionnaires were completed by the parents of 31 (86%) children with HAE, with or without their input, at a median age of nine years (range 1-17), and the physician also interviewed 29. HAE symptoms were experienced by 23 children, including abdominal attacks (96%), skin swelling (78%) and swelling in the mouth and/or upper airways (52%). Psychological stress was the most common trigger for abdominal attacks and trauma and sports triggered skin swelling. The majority (n = 19) had access to complement-1 esterase inhibitor concentrate at home. Current health and quality of life were generally rated as good, independent of whether the child had experienced HAE symptoms or not. ConclusionMost children with HAE had experienced abdominal attacks and skin swelling, but their overall health and quality of life were generally perceived to be good.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Children; Complement-1 esterase inhibitor defects; Epidemiology; Hereditary angioedema; Symptoms
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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