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1.	Waldenstrom, J, et al. (author) RIBAVIRIN MONOTHERAPY REDUCES HCVRNA IN ASSOCIATION WITH IL28B GENOTYPE AND ALSO IP-10 CONCENTRATIONS AMONG PATIENTS INFECTED WITH HEPATITIS C GENOTYPE 1 2014 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 60:1, s. S493-S493 Conference paper (other academic/artistic)
2.	Waldenström, Jesper, 1985, et al. (author) Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection 2016 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5 Journal article (peer-reviewed)abstract In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naive patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-alpha (pegIFN-alpha), (ii) 4 weeks ribavirin mono-therapy prior to adding pegIFN-alpha, or (iii) standard-of-care (SOC) ribavirin dosing concurrent with pegIFN-alpha. Four weeks of ribavirin mono-therapy resulted in a mean 0.46 log(10) IU/mL HCV RNA reduction differentially regulated across IL28B genotypes (0.89 vs. 0.21 log(10) IU/mL for CC and CT/TT respectively; P = 0.006), increased likelihood of undetectable HCV RNA week 4 after initiating pegIFN-alpha and thus shortened treatment duration (P < 0.05), and decreased median IP-10 concentration from 550 to 345 pg/mL (P < 0.001). Both experimental strategies impacted on ribavirin concentrations, and high levels were achieved after one week of double dosing. However, by day 14, double dosing entailed a greater hemoglobin decline as compared to SOC (2.2 vs. 1.4 g/dL; P = 0.03). Conclusion: Ribavirin down-regulates IP-10, and may have an antiviral effect differently regulated across IL28B genotypes.

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Type of publication: journal article (1); conference paper (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Christensen, P (2); Farkkila, M (2)Undo refine; Lindahl, K (2); Stenmark, S (2); Dalgard, O (2); Nilsson, Staffan, 19 ... (1); show more...; Norrgren, Hans (1); Waldenström, Jesper, ... (1); Lagging, Martin, 196 ... (1); Norkrans, Gunnar, 19 ... (1); Westin, Johan, 1965 (1); Buhl, M. R. (1); Nyström, Kristina, 1 ... (1); Krarup, H (1); Westin, J (1); Norrgren, H (1); WALDENSTROM, J (1); Lagging, M (1); Norkrans, G (1); Buhl, MR (1); Nystrom, K. (1); show less...

University: Karolinska Institutet (2)Undo refine; University of Gothenburg (1); Lund University (1); Chalmers University of Technology (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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