Sökning: WFRF:(Norrgren Hans)
> Albert J >
Increase in transmi...
Increase in transmitted drug resistance in migrants from sub-Saharan Africa diagnosed with HIV-1 in Sweden
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- Andersson, E. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Nordquist, A. (författare)
- Karolinska Institute
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- Esbjörnsson, Joakim (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Flamholc, Leo (författare)
- Skåne University Hospital
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- Gisslén, Magnus, 1962 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Hejdeman, B. (författare)
- Karolinska Institute,Karolinska Institutet
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- Marrone, G. (författare)
- Karolinska University Hospital
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- Norrgren, Hans (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Svedhem, V. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Wendahl, S. (författare)
- Sunderby Hospital
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- Albert, J. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Sönnerborg, A. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: AIDS. - 0269-9370. ; 32:7, s. 877-884
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: To study the trends of transmitted drug resistance (TDR) in HIV-1 patients newly diagnosed in Sweden, 2010-2016. Design: Register-based study including all antiretroviral therapy-naive patients ≥18 years diagnosed with HIV-1 in Sweden 2010-2016. Methods: Patient data and viral pol sequences were extracted from the national InfCareHIV database. TDR was defined as the presence of surveillance drug resistance mutations (SDRMs). A CD4+ T-cell decline trajectory model estimated time of infection. Phylogenetic inference was used for cluster analysis. Chi-square tests and logistic regressions were used to investigate relations between TDR, epidemiological and viral factors. Results: One thousand, seven hundred and thirteen pol sequences were analyzed, corresponding to 71% of patients with a new HIV-1 diagnosis (heterosexuals: 53%; MSM: 34%). The overall prevalence of TDR was 7.1% (95% CI 5.8-8.3%). Nonnucleoside reverse transcriptase inhibitor (NNRTI) TDR increased significantly from 1.5% in 2010 to 6.2% in 2016, and was associated to infection and/or origin in sub-Saharan Africa (SSA). An MSM transmission cluster dating back to the 1990s with the M41L SDRM was identified. Twenty-five (1.5%) patients exhibited TDR to tenofovir (TDF; n = 8), emtricitabine/lamivudine (n = 9) or both (n = 8). Conclusion: NNRTI TDR has increased from 2010 to 2016 in HIV-1-infected migrants from SSA diagnosed in Sweden, mirroring the situation in SSA. TDR to tenofovir/emtricitabine, used in preexposure prophylaxis, confirms the clinical and epidemiological need for resistance testing in newly diagnosed patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- antiretroviral drugs
- drug resistance
- HIV
- sub-Saharan Africa
- Sweden
- transients and migrants
- transmission
- antiretrovirus agent
- emtricitabine
- lamivudine
- nonnucleoside reverse transcriptase inhibitor
- Pol protein
- tenofovir
- adult
- Africa south of the Sahara
- antiviral resistance
- Article
- CD4+ T lymphocyte
- chi square test
- cluster analysis
- controlled study
- female
- gene mutation
- gene sequence
- heterosexuality
- human
- Human immunodeficiency virus 1 infection
- Human immunodeficiency virus infected patient
- logistic regression analysis
- major clinical study
- male
- men who have sex with men
- migrant
- phylogeny
- pre-exposure prophylaxis
- prevalence
- priority journal
- trend study
- virus transmission
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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AIDS
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- Av författaren/redakt...
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Andersson, E.
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Nordquist, A.
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Esbjörnsson, Joa ...
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Flamholc, Leo
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Gisslén, Magnus, ...
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Hejdeman, B.
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visa fler...
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Marrone, G.
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Norrgren, Hans
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Svedhem, V.
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Wendahl, S.
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Albert, J.
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Sönnerborg, A.
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Göteborgs universitet
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Karolinska Institutet
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Lunds universitet