Sökning: WFRF:(Nygren Peter)
> (2005-2009)
> Månsson Jan Eric 1946 >
Localization of lip...
Localization of lipids in the aortic wall with imaging TOF-SIMS
-
- Malmberg, Per, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
-
Borner, K. (författare)
-
- Chen, Yun, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
-
visa fler...
-
- Friberg, Peter, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
-
Hagenhoff, B. (författare)
-
Månsson, Jan-Eric, 1946 (författare)
-
- Nygren, Håkan, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
-
visa färre...
-
(creator_code:org_t)
- 2007
- 2007
- Engelska.
-
Ingår i: Biochim Biophys Acta. - 0006-3002. ; 1771:2, s. 185-95
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://research.cha...
-
visa färre...
Abstract
Ämnesord
Stäng
- Time-of-flight secondary-ion-mass-spectrometry (TOF-SIMS) was utilized to address the issue of localization of lipids and inorganic ions in healthy rat aorta and human atherosclerotic plaque. Pieces of rat aorta were high pressure frozen, freeze-fractured and freeze dried. The samples were analyzed by imaging TOF-SIMS equipped with a Bi(1-7)(+)-source. Reference lipid samples were analyzed and compared to data obtained by analysis of the rat aorta samples. Fatty acids, cholesterol, oxysterol and diacylglycerols were detected and localized. A heterogeneous lipid distribution could be shown in the aorta, where the lamellae of the aorta, distinguished by imaging of CN(-), appeared enriched in cholesterol, oxysterol and diacylglycerols, while the smooth muscle tissue, identified by imaging of PO(3), appeared enriched in phosphocholine. Palmitic/palmitoleic acid and stearic/oleic acid appeared to be heterogeneously distributed over the aorta with high concentration areas located especially in the tunica media region of the aorta. Human atherosclerotic plaque showed an irregular cholesterol distribution mainly located in spots in the intima region with elongated diacylglycerol regions located mainly in the media region.
Nyckelord
- Animals
- Aorta/*metabolism/ultrastructure
- Atherosclerosis/metabolism
- Cholesterol/metabolism
- Fatty Acids
- Monounsaturated/metabolism
- Freeze Drying
- Humans
- Lipids/*analysis
- Oleic Acid/metabolism
- Palmitic Acid/metabolism
- Rats
- Rats
- Sprague-Dawley
- Spectrometry
- Mass
- Secondary Ion/*methods
- Stearic Acids/metabolism
- Sprague-Dawley
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Malmberg, Per, 1 ...
-
Borner, K.
-
Chen, Yun, 1966
-
Friberg, Peter, ...
-
Hagenhoff, B.
-
Månsson, Jan-Eri ...
-
visa fler...
-
Nygren, Håkan, 1 ...
-
visa färre...
- Artiklar i publikationen
-
Biochim Biophys ...
- Av lärosätet
-
Göteborgs universitet
-
Chalmers tekniska högskola