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Träfflista för sökning "WFRF:(O'Neill Barry) "

Sökning: WFRF:(O'Neill Barry)

  • Resultat 1-10 av 14
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1.
  • 2021
  • swepub:Mat__t
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2.
  • Clark, Andrew G., et al. (författare)
  • Evolution of genes and genomes on the Drosophila phylogeny.
  • 2007
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
  • Tidskriftsartikel (refereegranskat)abstract
    • Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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  • Lindblad-Toh, Kerstin, et al. (författare)
  • Genome sequence, comparative analysis and haplotype structure of the domestic dog.
  • 2005
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
  • Tidskriftsartikel (refereegranskat)abstract
    • Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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4.
  • Thomas, HS, et al. (författare)
  • 2019
  • swepub:Mat__t
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5.
  • Ademuyiwa, Adesoji O., et al. (författare)
  • Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
  • 2016
  • Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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7.
  • Glasbey, JC, et al. (författare)
  • 2021
  • swepub:Mat__t
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8.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
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9.
  • Blondel, Ylva Isabelle, 1972- (författare)
  • The Power of Symbolic Power : An Application of O'Neill's Game of Honour to Asymmetric Internal Conflict
  • 2004
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Powerful states can lose wars to militarily weaker opponents. This can only be understood by moving away from an over-simplified traditional definition of power and by incorporating the symbolic dimensions of power. The present study focuses on honour, which is one facet of symbolic power that is particularly relevant for understanding conflict because it is often associated with publicly participating in violence. Barry O’Neill’s Game of Honour model, originally developed for inter-state relations, provides a structured framework to analyse the strategic use of symbols in internal asymmetric conflicts. The main claim in this dissertation is that because there is only one recognised state apparatus competition is always for the same audience. I argue that this makes it difficult to assume that the state can adequately foresee the audience’s expectations, and that outcomes of a challenge can best be understood as the relative honour of the primary actors. Two cases were selected from the recent conflict in Algeria to empirically apply the model. The first is a public demonstration that occurred in Algiers in 1991 and involves a domestic news media audience, while the second is a plane hijacking that involves a Western news media audience. Six other cases are also considered with the aim of highlighting salient issues relevant to incorporating other dimensions of symbolic power connected, but not equal, to honour. The application of the model to the cases clearly reflects that symbolic challenges can be perceived as serious threats to actors who are militarily far superior. This suggests that key events can alter the relative power balance in asymmetric conflicts and, therefore, it is not possible to assume that symbolic power is merely a reflection of underlying material capabilities as a traditional definition of power implies.
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  • Resultat 1-10 av 14

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