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Designing Endocrine...
Designing Endocrine Disruption Out of the Next Generation of Chemicals
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- Schug, Thaddeus T. (författare)
- National Institute of Environmental Health Sciences, Research Triangle Park, USA
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- Abagyan, Ruben A. (författare)
- University of California, San Diego, San Diego, USA
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- Blumberg, Bruce W. (författare)
- University of California, Irvine, USA
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- Collins, Terrence J. (författare)
- Carnegie Mellon University, Pittsburgh, USA
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- Crews, David P. (författare)
- University of Texas at Austin, Austin, USA
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- DeFur, Peter L. (författare)
- Virginia Commonwealth University, Richmond, USA
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- Dickerson, Sarah M. (författare)
- Advancing Green Chemistry, Charlottesville, USA
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- Edwards, Thea M. (författare)
- Louisiana Tech University, Ruston, USA
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- Gore, Andrea C. (författare)
- The University of Texas at Austin, Austin, USA
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- Guillette, Louis Joseph (författare)
- Medical University of South Carolina, Charleston, USA
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- Hayes, Tyrone B. (författare)
- University of California, Berkeley, USA
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- Heindel, Jerrold J. (författare)
- National Institute of Environmental Health Sciences, Research Triangle Park, USA
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- Moores, Audrey (författare)
- McGill University, Montréal, Canada
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- Patisaul, Heather B. (författare)
- North Carolina State University, Raleigh, USA
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- Tal, Tamara L. (författare)
- Oregon State University, Corvallis, USA
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- Thayer, Kristina A. (författare)
- National Institute of Environmental Health Sciences, Research Triangle Park, USA
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- Vandenberg, Laura N. (författare)
- Tufts University, Medford, USA
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- Warner, John C. (författare)
- Warner Babcock Institute for Green Chemistry, Wilmington, USA
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- Watson, Cheryl S. (författare)
- University of Texas Medical Branch, Galveston, USA
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- Vom Saal, Frederick S. (författare)
- University of Missouri-Columbia, Columbia, USA
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- Zoeller, R. Thomas, 1952- (författare)
- Department of Biology, University of Massachusetts, Amherst, USA
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- O'Brien, Karen Peabody (författare)
- Advancing Green Chemistry, Charlottesville, USA
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- Myers, John Peterson (författare)
- Environmental Health Sciences, Charlottesville, USA
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(creator_code:org_t)
- Royal Society of Chemistry, 2013
- 2013
- Engelska.
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Ingår i: Green Chemistry. - : Royal Society of Chemistry. - 1463-9262 .- 1463-9270. ; 15:1, s. 181-198
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has been inadequately addressed by both industrial and regulatory science. To aid chemists in avoiding this hazard, we propose an endocrine disruption testing protocol for use by chemists in the design of new chemicals. The Tiered Protocol for Endocrine Disruption (TiPED) has been created under the oversight of a scientific advisory committee composed of leading representatives from both green chemistry and the environmental health sciences. TiPED is conceived as a tool for new chemical design, thus it starts with a chemist theoretically at "the drawing board." It consists of five testing tiers ranging from broad in silico evaluation up through specific cell- and whole organism-based assays. To be effective at detecting endocrine disruption, a testing protocol must be able to measure potential hormone-like or hormone-inhibiting effects of chemicals, as well as the many possible interactions and signaling sequellae such chemicals may have with cell-based receptors. Accordingly, we have designed this protocol to broadly interrogate the endocrine system. The proposed protocol will not detect all possible mechanisms of endocrine disruption, because scientific understanding of these phenomena is advancing rapidly. To ensure that the protocol remains current, we have established a plan for incorporating new assays into the protocol as the science advances. In this paper we present the principles that should guide the science of testing new chemicals for endocrine disruption, as well as principles by which to evaluate individual assays for applicability, and laboratories for reliability. In a 'proof-of-principle' test, we ran 6 endocrine disrupting chemicals (EDCs) that act via different endocrinological mechanisms through the protocol using published literature. Each was identified as endocrine active by one or more tiers. We believe that this voluntary testing protocol will be a dynamic tool to facilitate efficient and early identification of potentially problematic chemicals, while ultimately reducing the risks to public health.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
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- Enviromental Science
- Miljövetenskap
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Schug, Thaddeus ...
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Abagyan, Ruben A ...
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Blumberg, Bruce ...
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Collins, Terrenc ...
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Crews, David P.
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DeFur, Peter L.
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visa fler...
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Dickerson, Sarah ...
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Edwards, Thea M.
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Gore, Andrea C.
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Guillette, Louis ...
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Hayes, Tyrone B.
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Heindel, Jerrold ...
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Moores, Audrey
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Patisaul, Heathe ...
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Tal, Tamara L.
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Thayer, Kristina ...
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Vandenberg, Laur ...
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Warner, John C.
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Watson, Cheryl S ...
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Vom Saal, Freder ...
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Zoeller, R. Thom ...
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O'Brien, Karen P ...
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Myers, John Pete ...
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