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1.	Artigas Soler, María, et al. (author) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. 2011 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1082-90 Journal article (peer-reviewed)abstract Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
2.	Soler Artigas, María, et al. (author) Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. 2011 In: American journal of respiratory and critical care medicine. - 1535-4970. ; 184:7, s. 786-95 Journal article (peer-reviewed)abstract Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population samples, but their association with chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have their combined effects on lung function and COPD been studied.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Heinrich, Joachim (2); Cooper, Cyrus (2); Wareham, Nicholas J. (2); Surakka, Ida (2); Ripatti, Samuli (2); Kähönen, Mika (2); show more...; Marchini, Jonathan (2); Nyberg, Fredrik, 196 ... (2); Albrecht, Eva (2); Karrasch, Stefan (2); Schulz, Holger (2); Olin, Anna-Carin, 19 ... (2); Barroso, Ines (2); Heliövaara, Markku (2); Wain, Louise V (2); Rantanen, Taina (1); Pin, Isabelle (1); Imboden, Medea (1); Probst-Hensch, Nicol ... (1); Hardy, Rebecca (1); Kuh, Diana (1); Rochat, Thierry (1); Torinsson Naluai, Ås ... (1); Campbell, Harry (1); Rudan, Igor (1); Strachan, David P (1); North, Kari E. (1); Rotter, Jerome I. (1); Brisman, Jonas, 1954 (1); Mangino, Massimo (1); Gieger, Christian (1); Wichmann, H. Erich (1); Spector, Tim D. (1); Kaprio, Jaakko (1); Boezen, H Marike (1); Vonk, Judith M (1); Dominiczak, Anna F. (1); Pavord, Ian D. (1); Ramasamy, Adaikalava ... (1); Jarvis, Deborah L. (1); Wright, Alan F. (1); Wilson, James F. (1); Gu, Xiangjun (1); Deary, Ian J (1); Henderson, John (1); Holt, Patrick G. (1); Rivadeneira, Fernand ... (1); Kronenberg, Florian (1); Artigas Soler, María (1); Loth, Daan W (1); show less...

University: University of Gothenburg (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2011 (2)Undo refine

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