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- Tapper, Sofie, et al.
(författare)
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Influence of editing pulse flip angle on J-difference MR spectroscopy
- 2021
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Ingår i: Magnetic Resonance in Medicine. - : WILEY. - 0740-3194 .- 1522-2594.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To investigate the editing-pulse flip angle (FA) dependence of editing efficiency and ultimately to maximize the edited signal of commonly edited MR spectroscopy (MRS) signals, such as gamma-aminobutyric acid (GABA) and lactate. Methods Density-matrix simulations were performed for a range of spin systems to find the editing-pulse FA for maximal editing efficiency. Simulations were confirmed by phantom experiments and in vivo measurements in 10 healthy participants using a 3T Philips scanner. Four MEGA-PRESS in vivo measurements targeting GABA+ and lactate were performed, comparing the conventional editing-pulse FA (FA = 180 degrees) to the optimal one suggested by simulations (FA = 210 degrees). Results Simulations and phantom experiments show that edited GABA and lactate signals are maximal at FA = 210 degrees. Compared to conventional editing (FA = 180 degrees), in vivo signals from GABA+ and lactate signals increase on average by 8.5% and 9.3%, respectively. Conclusion Increasing the FA of editing-pulses in the MEGA-PRESS experiment from 180 degrees to 210 degrees increases the edited signals from GABA+ and lactate by about 9% in vivo.
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