SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Ohlsson Claes) "

Sökning: WFRF:(Ohlsson Claes)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Ahmad, Tashfeen, et al. (författare)
  • Peripheral quantitative computed tomography for the detection of diabetic osteopathy: a study in the Goto-Kakizaki rat.
  • 2003
  • Ingår i: Investigative radiology. - 0020-9996. ; 38:3, s. 171-6
  • Tidskriftsartikel (refereegranskat)abstract
    • RATIONALE AND OBJECTIVE: To assess the utility of dual energy x-ray absorptiometry (DEXA) and peripheral quantitative computed tomography (pQCT) in detecting trabecular and cortical bone changes in diabetes as a model of osteopenia. MATERIALS AND METHODS: The tibia from 10 type-2 diabetic Goto-Kakizaki (GK) rats and 10 control Wistar rats were analyzed by DEXA, pQCT, and ash weight determination. RESULTS: DEXA of GK rats showed a significant reduction in mineral content (32%) and density (24%) of the metaphysis, but not of the diaphysis. PQCT disclosed that the reduction of density predominantly pertained to the trabecular bone (reduced by 62%). Periosteal and endosteal circumferences of the diaphyses were increased and cortical thickness was unchanged leading to increased moment of inertia. CONCLUSIONS: This study suggests that in osteopathic conditions, cortical and trabecular bone should be separately examined within specific subregions to obtain relevant information. Loss of metaphyseal trabecular bone seems to be a predominant feature in diabetic rats. Moreover, there is increased moment of inertia in the diaphysis implying increased strength. These diagnostic features of diabetic osteopathy can only be assessed by pQCT. It may prove that similar changes occur in human type-2 diabetes, which could explain the susceptibility to periarticular fracture and Charcot arthropathy.
  •  
2.
  • den Hoed, Marcel, et al. (författare)
  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
  • 2013
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 45:6, s. 621-
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.
  •  
3.
  • Engstrand, Thomas, et al. (författare)
  • A novel biodegradable delivery system for bone morphogenetic protein-2.
  • 2008
  • Ingår i: Plastic and reconstructive surgery. - 1529-4242. ; 121:6, s. 1920-8
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The efficacy of recombinant growth factors in vivo is highly dependent on the delivery vehicle. The authors investigated the osteoinductive effects of recombinant human bone morphogenetic proteins (BMP)-2 implanted together with a complex of heparin and chitosan. METHODS: Sixty rats were used. Three different carriers in gel formulation (type I collagen, heparin/type I collagen, and heparin/chitosan) were mixed with either 0, 10, or 50 microg of BMP-2, making the number of groups nine. The gels were injected into the quadriceps muscles of both legs in 45 rats (n = 10 per group). Freeze-dried formulations of the carriers were also tested with the same amounts of BMP-2 using 15 rats (n = 5 per group). Four weeks after implantation, the quality and amount of newly formed bone were assessed. RESULTS: Chitosan was shown to protect the heparinase-mediated degradation of heparin in vitro. The osteoinductive effects of BMP-2 in combination with heparin/chitosan were superior as compared with BMP-2 implanted together with type I collagen. Interestingly, the heparin/chitosan complex induced a small amount of bone also without BMP-2 added. The heparin/chitosan was completely absorbed after 4 weeks as determined by histologic evaluation, and a normal active bone formation was present. The freeze-dried formulations of the carriers demonstrated similar osteoinductive effects as the gels. CONCLUSIONS: An osteoinductive formula for clinical use is needed for general bone reconstruction. Heparin in complex with chitosan has the ability to stabilize or activate the growth factor in vivo and induce the generation of new bone in good yields.
  •  
4.
  • Ahmad, T, et al. (författare)
  • Skeletal changes in type-2 diabetic Goto-Kakizaki rats.
  • 2003
  • Ingår i: The Journal of endocrinology. - 0022-0795. ; 178:1, s. 111-6
  • Tidskriftsartikel (refereegranskat)abstract
    • We characterized appendicular and axial bones in rats with type-2 diabetes in five female Goto-Kakizaki (GK) rats, a strain developed from the Wistar rat showing spontaneous type-2 diabetes, and five age- and sex-matched non-diabetic Wistar rats. The humerus, tibia, metatarsals and vertebral bodies were analysed by peripheral quantitative computerized tomography (pQCT). In diabetic rats, the height of the vertebral bodies and length of the humerus were decreased while the length of the metatarsals was increased. A decreased cross-sectional area was found in the vertebral end-plate region and the tibial metaphysis. Notably, the diaphysis in all long bones showed expansion of periosteal and endosteal circumference. In tibia this resulted in increased cortical thickness, whereas in humerus and metatarsal it was unchanged. Areal moment of inertia was increased in all diaphyses suggesting greater bending strength. The most conspicuous finding in diabetic rats pertained to trabecular osteopenia. Thus, trabecular bone mineral density was significantly reduced in all bones examined, by 33-53%. Our pQCT study of axial and appendicular bones suggests that the typical feature of diabetic osteopathy in the GK rat is loss of trabecular bone and expansion of the diaphysis. The loss of metaphyseal trabecular bone if also present in diabetic patients may prove to underlie the susceptibility to periarticular fracture and Charcot arthropathy. The findings suggest that the risk of fracture in diabetes varies according to the specific sub-regions of a bone. The approach described may prove to be useful in the early detection of osteopathy in diabetic patients who may be amenable to preventive treatment.
  •  
5.
  • Ahrné, Karin, et al. (författare)
  • Rödlista över fjärilar Lepidoptera
  • 2015
  • Ingår i: Rödlistade arter i Sverige 2015. - Uppsala : ArtDatabanken SLU. - 978-91-87853-10-4 ; s. 98-112
  • Bokkapitel (övrigt vetenskapligt)
6.
7.
  • Allen, Hana Lango, et al. (författare)
  • Hundreds of variants clustered in genomic loci and biological pathways affect human height.
  • 2010
  • Ingår i: Nature. - 1476-4687. ; 467:7317, s. 832-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
  •  
8.
  • Almehed, Katarina, 1966-, et al. (författare)
  • Prevalence and risk factors of osteoporosis in female SLE patients-extended report
  • 2007
  • Ingår i: Rheumatology (Oxford). - 1462-0324 (Print). ; 46:7, s. 1185-90
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: To determine the frequency of osteoporosis and possible risk factors of low bone mineral density (BMD) in women with systemic lupus erythematous (SLE) in western Sweden. In addition, to evaluate if adequate anti-osteoporotic treatment was provided. METHODS: BMD was measured at radius, lumbar spine and hip by dual X-ray absorptiometry (DXA). An 'expected' control BMD was calculated for each patient. Simple and multiple linear regression analyses were performed to determine associations between BMD and demographic and disease-related variables. RESULTS: One hundred and sixty-three women were included. Median age was 47 (20-82) yrs, 89 (55%) were post-menopausal and 85 (52%) were taking glucocorticosteroids. BMD was significantly reduced in all measured sites compared with expected BMD. Thirty-seven (23%), 18 (11%) and 6 (4%) of the patients were osteoporotic in at least one, two and three or more measured locations. Bisphosphonates were used by 23 (27%) of patients taking glucocorticosteroids and 13 (35%) with osteoporosis. High age and low weight or BMI were associated with low BMD in all measured sites. In total hip, high SLICC/American Collage of Rheumatology (ACR), ESR and 'combinations of DMARD' were additional markers of low BMD. High S-creatinine was associated with low BMD in lumbal spine whereas high S-creatinine and CRP were markers in radius. CONCLUSION: Women with SLE are at greater risk of osteoporosis compared with controls and few are treated adequately. Factors associated with low BMD in SLE are high age and low weight but also markers of inflammation, impaired kidney function and disease damage, however glucocorticosteroids were not associated.
  •  
9.
  • Almehed, Katarina, et al. (författare)
  • Prevalence and risk factors of vertebral compression fractures in female SLE patients.
  • 2010
  • Ingår i: Arthritis research & therapy. - 1478-6362. ; 12:4
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: Our objective was to determine the frequency of and factors associated with prevalent vertebral compression fractures in female systemic lupus erythematosus (SLE) patients attending rheumatologists in western Sweden.METHODS: In this cross sectional study 150 women were included. They were examined with x-ray of thoracic and lumbar spine (Th4 to L4). A reduction of at least 20% of any vertebral height, assessed by Genant's semiquantitative method, was defined as a fracture. Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry (DXA).RESULTS: Median patient age was 47 years (20 to 82) and disease duration 11 years (1 to 41). Only 6 (4%) women had a history of clinical compressions whereas 43 (29%) had at least one radiological fracture each. The patients with at least one fracture at any site were characterized by older age (P < 0.001), being postmenopausal (P < 0.01), higher Systemic Lupus International Collaborative Clinics Damage Index (P < 0.05), lower BMD total hip and femoral neck (P < 0.05), more peripheral fractures (P < 0.01), medication with bisphosphonates (P <0.05) and calcium and vitamin D3 (P < 0.05). There were no significant differences regarding current or cumulative glucocorticosteroid dose between the groups. In logistic regression analyses high age remained as a risk factor of at least one vertebral fracture at any site whereas low BMD in total hip was associated with vertebral fracture in the lumbar spine.CONCLUSIONS: Radiological compression fractures are common but seldom diagnosed in SLE patients. High age and low BMD in total hip, but not in spine, was associated with vertebral fractures.
  •  
10.
  • Amzaleg, Y., et al. (författare)
  • Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells
  • 2018
  • Ingår i: Journal of Steroid Biochemistry and Molecular Biology. - 0960-0760. ; 183, s. 10-17
  • Tidskriftsartikel (refereegranskat)abstract
    • Estrogens attenuate bone turnover by inhibiting both osteoclasts and osteoblasts, in part through antagonizing Runx2. Apparently conflicting, stimulatory effects in osteoblast lineage cells, however, sway the balance between bone resorption and bone formation in favor of the latter. Consistent with this dualism, 17 beta-estradiol (E2) both stimulates and inhibits Runx2 in a locus-specific manner, and here we provide evidence for such locus specific regulation of Runx2 by E2 in vivo. We also demonstrate dual, negative and positive, regulation of Runx2-driven alkaline phosphatase (ALP) activity by increasing E2 concentrations in ST2 osteoblast progenitor cells. We further compared the effects of E2 to those of the Selective Estrogen Receptor Modulators (SERMs) raloxifene (ral) and lasofoxifene (las) and the phytoestrogen puerarin. We found that E2 at the physiological concentrations of 0.1-1 nM, as well as ral and las, but not puerarin, antagonize Runx2-driven ALP activity. At >= 10 nM, E2 and puerarin, but not ral or las, stimulate ALP relative to the activity measured at 0.1-1 nM. Contrasting the difference between E2 and SERMs in ST2 cells, they all shared a similar dose-response profile when inhibiting preosteoclast proliferation. That ral and las poorly mimic the locus-and concentration-dependent effects of E2 in mesenchymal progenitor cells may help explain their limited clinical efficacy.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (104)
Typ av publikation
tidskriftsartikel (595)
konferensbidrag (37)
bokkapitel (23)
annan publikation (8)
bok (5)
forskningsöversikt (5)
visa fler...
rapport (4)
doktorsavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (606)
övrigt vetenskapligt (73)
populärvet., debatt m.m. (1)
Författare/redaktör
Ohlsson, Claes, 1965 ... (389)
Ohlsson, Claes (187)
Mellström, Dan, (94)
Ljunggren, Östen, (85)
Mellström, Dan, 1945 ... (76)
Lorentzon, Mattias, (74)
visa fler...
Karlsson, Magnus, (69)
Mellstrom, Dan (64)
Lorentzon, Mattias, ... (63)
Vandenput, Liesbeth (57)
Ljunggren, Osten (57)
Karlsson, Magnus K., (55)
Sjögren, Klara, 1970 ... (47)
Vandenput, Liesbeth, ... (45)
Rivadeneira, Fernand ... (41)
Hofman, Albert, (40)
Carlsten, Hans, 1954 ... (40)
Windahl, Sara H, 197 ... (36)
Jansson, John-Olov, ... (35)
Isaksson, Olle, 1943 ... (35)
Uitterlinden, Andre ... (34)
Movérare-Skrtic, Sof ... (34)
Eriksson, Joel, (33)
Harris, Tamara B. (33)
Kiel, Douglas P (28)
Kindblom, Jenny, 197 ... (27)
Lagerquist, Marie, 1 ... (26)
Medina-Gomez, Caroli ... (26)
Gudnason, Vilmundur, (24)
Zillikens, M. Carola (24)
Islander, Ulrika, 19 ... (24)
Estrada, Karol (23)
Hayward, Caroline (23)
Campbell, Harry (23)
Wilson, James F. (23)
Karasik, David (23)
Van Duijn, Cornelia ... (22)
Gustafsson, J. A. (22)
Mangino, Massimo (22)
Lerner, Ulf H, (22)
Grundberg, Elin (22)
Liu, Yongmei (22)
Mallmin, Hans, (21)
Amin, Najaf, (21)
Psaty, Bruce M., (21)
Wareham, Nicholas J. (21)
Luan, Jian'an (21)
Feitosa, Mary F. (21)
Richards, J Brent (21)
Labrie, Fernand (21)
visa färre...
Lärosäte
Göteborgs universitet (564)
Lunds universitet (168)
Uppsala universitet (126)
Karolinska Institutet (118)
Chalmers tekniska högskola (52)
Umeå universitet (40)
visa fler...
Linnéuniversitetet (24)
Luleå tekniska universitet (6)
Försvarshögskolan (6)
Högskolan i Skövde (5)
Blekinge Tekniska Högskola (5)
Linköpings universitet (4)
Högskolan Dalarna (4)
Örebro universitet (2)
Högskolan i Borås (2)
Stockholms universitet (1)
Högskolan i Gävle (1)
visa färre...
Språk
Engelska (629)
Svenska (38)
Odefinierat språk (1)
Kinesiska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (582)
Naturvetenskap (40)
Samhällsvetenskap (40)
Humaniora (38)
Teknik (14)
Lantbruksvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy